Hydrocephalus-induced changes in the composition of cerebrospinal fluid.

Abstract:

:Studies reporting the composition of cerebrospinal fluid obtained from hydrocephalic humans have been critically reviewed. Hydrocephalus-induced alterations in the cerebrospinal fluid concentrations of neurotransmitters and peptide neuromodulators, products of glycolysis and nucleotide metabolism, neural cell-derived proteins and enzymes, and serum-derived proteins have been documented. The data are interpreted with reference to experimental studies. The reported changes suggest that in the hydrocephalic brain there are disturbances of oxidative metabolism and neurotransmission, and perhaps damage to periventricular cells particularly when intracranial pressure is elevated. Although no assays have provided and entirely useful guide to aid decisions regarding shunt therapy, they have provided in vivo information regarding the pathophysiology of hydrocephalus.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Del Bigio MR

doi

10.1097/00006123-198909000-00016

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

416-23

issue

3

eissn

0148-396X

issn

1524-4040

journal_volume

25

pub_type

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