Abstract：
:The purpose of this study was to investigate prognostic significance of Dopamine and cAMP-Regulated neuronal Phosphoprotein 32 (DARPP-32) expression in primary colorectal cancer. The study material consisted of clinical and histopathological data of 100 patients operated for colorectal cancer between 1994 and 1997. For immunohistochemical analysis, specific rabbit antibodies for DARPP-32 were used and the percentage of stained tumor cells was calculated under gross magnification (400 times) on a sample of 500 tumor cells. DARPP-32 expression in the primary tumor was significantly greater in patients with distant metastases compared to patients with no distant metastases (p=0.002). In multivariate regression analysis, DARPP-32 expression in the primary tumor was a significant predictor of distant metastases. With a cut-off point of 76.5%, DARPP-32 expression in the primary tumor significantly influenced both overall and disease free survival, especially for Dukes A and B patients (p=0.037). The results of this study indicate that DARPP-32 may be a potential marker of worse prognosis and a valuable tool for managing further adjuvant treatment in patients with stages Dukes A and B colorectal cancer.
journal_name
Int Surgjournal_title
International surgeryauthors
Kopljar M,Patrlj L,Korolija-Marinic D,Horzic M,Cupurdija K,Bakota Bdoi
10.9738/INTSURG-D-14-00022.1subject
Has Abstractpub_date
2015-02-01 00:00:00pages
213-20issue
2eissn
0020-8868issn
2520-2456journal_volume
100pub_type
杂志文章abstract：:The standard surgical approach to multiple polyposis has been a total proctocolectomy and an end ileostomy because of the premalignant nature of the disease. This operation has been successful, but has resulted in a significant amount of psychological trauma due to the presence of an abdominal stoma. For that reason, ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:Two hundred and seven patients aged from 37 to 65 years with noninflammatory breast cancer treated by surgery without radiation were studied over a ten year period with a view to forecasting the prognosis on the basis of the immune status and treatment. The immunocompetence or immune status was studied in 121 patients...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Our goals were to (1) identify risk factors associated with conversion from laparoscopic to open appendectomies and (2) establish criteria that predict the possibility of conversion to an open technique. We did a retrospective chart review of all patients who underwent laparoscopic appendectomies during a 5-year perio...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00058.1
更新日期：2013-10-01 00:00:00
abstract：:In 17 years we have performed 6,505 neurosurgical procedures in the neurosurgical unit of the Salisbury Hospital Group. Only 62% were performed on Africanpatients and 38% on European patients, despite the fact that the African population exceeds the European population by 20 times. This is partly due to the tolerance ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：:Induction of transplant tolerance is a clinically desirable goal. To provide unbiased insight into transplant tolerance, we analyzed gene expression profiling in peripheral blood mononuclear cells from recipients of living-donor liver transplants (LDLTs) who had retained an immune tolerance with a well-functioning gra...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Bronchobiliary fistula (BBF) is a rare condition which occurs most commonly as a complication of hydatid cyst liver disease. The following report describes a patient who presented with biliptysis 6 months following decortication of an empyema that had occurred following partial hepatectomy of a colon cancer metastasis...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00095.1
更新日期：2014-07-01 00:00:00
abstract：:Of the 365 surgical techniques performed on the aorto-iliac area in 354 patients, 448 extremities were revascularized by means of the insertion of a prosthesis as a by-pass, and 165 by thromboendarterectomy (TEA), either global or ilio-femoral. The patency rate at five years was 83% for prostheses, and 72% for TEAs, s...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:The purpose of this study was to clarify the rate and characteristics of conscious disorder without intracranial hemorrhagic injury in polytrauma patients. The medical records of polytrauma patients with conscious disorder without intracranial hemorrhagic injury were reviewed. Fifty-five patients (35.3% of 156 polytra...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:The diagnosis and management of ovarian hemorrhage complicating anticoagulant therapy is discussed and a case presented. The patient, who had undergone mitral valve replacement and was receiving chronic anticoagulation treatment, was admitted with signs of intraperitoneal bleeding from a ruptured ovarian hematoma. Thi...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:To inhibit local recurrence of rectal cancer, it is very important to ensure that there is a sufficient circumferential resection margin. We evaluated pathology studies of combined radical resection of seminal vesicles in the treatment of rectal cancer. We analyzed data from 7 cases of combined radical resection of th...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/1362.1
更新日期：2011-01-01 00:00:00
abstract：:Progress in the development of suture materials results in a lower rate of fistulas. Modern techniques for the diagnosis of leakage (contrast study, CT-scan) allow for an early diagnosis and adequate therapy: if possible conservative therapy with drainage of the abscess, adapted antibiotic therapy and parenteral and e...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:For a variety of reasons, mainly anatomical, the skin and soft tissue defects in the lower leg and foot remain a challenging problem for reconstructive surgeons. Simple skin grafts, local random flaps, cross leg flaps, microvascular flaps, etc., have been used to tackle this difficult problem. Although to date, probab...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:This is the first publication of a rare benign tumor; mesenteric panniculitis causing acute on chronic ischemic bowel injury. ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:A review of 238 patients aged over 75 years and operated on for colorectal cancer was undertaken to analyse factors influencing short and long-term operative mortality. Operative mortality in the first postoperative month was 13% (n = 31) and 17% (n = 35) in the first year. Four factors influenced significantly postop...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Gastroduodenal anastomosis is not routine during reoperation for stomal ulcers after primary Billroth II gastrectomy. It nevertheless is a sure way to prevent an increased peptic potential which is brought about by a duodenal bypass. We have reviewed the published cases and added three more, bringing the total to 47. ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1975-10-01 00:00:00
abstract：:Massive lower gastrointestinal hemorrhage originates in the colon in 70% of cases. In half the remaining cases it originates in the small bowel, and in the other half in the duodenum. Currently available diagnostic techniques are: mesenteric angiography, barium contrast meal studies, colonoscopy, and laparotomy. Cause...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Central bisegmentectomy (CBS) of the liver is an en bloc hepatic resection of Couiaud segments 4, 5, and 8. The indications for CBS include benign and malignant tumors occupying both the left medial and right anterior segments. However, CBS has rarely been reported. Here, we investigate CBS in patients with suboptimal...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00163.1
更新日期：2014-09-01 00:00:00
abstract：:The indications, results and evaluation methods of lumbar sympathectomy are very controversial. The authors present their experience and results with phenol lumbar sympathectomy (PLS). PLS (Reid's technique) was carried out in 25 patients with severe peripheral arterial disease. Sympathetic tone abolition was achieved...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:This paper reports an unusual case of orthopedic trauma in a 29-year-old man who experienced concomitant bilateral anterior shoulder fracture dislocation with associated brachial plexus and axillary artery injury. We also highlight the mechanism underlying this rare workplace injury related to use of a forklift. ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare EXT and RDL. The re...
journal_title：International surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The effect on cellular immunity of the administration of the non-specific immunopotentiator BCG and/or a streptococcal agent was studied in 90 non-cancer bearing Wistar rats under different nutritional support. The number of immunocompetent cells and the non-specific function of the immunocompetent cells significantly...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Results of immediate reconstruction of the defects resulting from excision of cancer of the cheek, lower jaw, upper jaw and lip in 13 patients using temporal island, deltopectoral and cervicoacromial flaps have been described. The surgical techniques have been outlined. Previous radiotherapy is not a contraindication ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:We examined eight patients with adenocarcinoma of the small intestine: four were localized in the duodenum and four in the jejunum. We performed six curative resections: two pancreatoduodenectomy, two total pancreatectomy and two jejunal resections; in two cases, only by-pass was performed. Three patients who were res...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:We evaluated in retrospect the applicability of conservative hepatic resection for hepatocellular carcinoma (HCC) of cirrhotic patients. Eighty (14.6%) of 548 patients with HCC underwent liver resection over a period of 10 years in this hospital. They were divided into two groups according to surgical procedures. In g...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:The authors performed a total of 237 endolaser treatments for insufficiency of great and small saphenous veins and assessed 5-year results. It was found that this method, especially if performed with a 1470-nm-wavelength laser combined with instrumental removal of some lateral veins, was very effective. It was delicat...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Traumatic rupture of thoracic aorta caused by blunt trauma has been observed more frequently in recent years. The aim of this study was to evaluate the state of the art of diagnostic methods used to identify this injury and the surgical techniques used to repair it. METHODS:The study was performed in 29 pat...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In an attempt to assess the different methods of treatment of tumors of the esophagus we contacted 170 surgeons (in 1975-1976). Seventy-six (45%) answered a questionnaire concerning the surgical management of esophageal tumors, the reasons for non operability and non resectability, the place of radiotherapy, the valid...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:The history of inguinal herniorrhaphy certainly presents some peculiar aspects. Until the 18th century this disease was studied with interest and found a place in the books of several important authors, but in practice it was treated by empiricists and barbers. We must recognize however that some of their surgical met...
journal_title：International surgery
pub_type： 历史文章,杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:We operated on 138 patients for intestinal obstruction. The different causes are discussed and their pattern of occurrence is compared with that reported from England and other African countries. The 27.6% mortality rate was closely associated with the 28.2% incidence of gangrene. Factors which may lower this high mor...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:A total of 52 patients with different grades of liver injuries were treated in a 1 year period: 32 patients had penetrating injuries and in 20 patients injuries resulted from blunt trauma. Blunt trauma victims were frequently associated with chest and head injuries and with skeletal fractures. A 4-fold incidence of as...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
