Abstract：
AIM:Cerebellar injury is a characteristic injury associated with preterm infants. However, the impact of cerebellar injury on the development of preterm infants is unclear. METHOD:We reviewed magnetic resonance image studies of preterm infants with cerebral palsy retrospectively and evaluated the developmental outcomes. RESULTS:Cerebellar injury was recognized in 9 (2.4%) of 381 patients with cerebral palsy who were born preterm. The median gestational age was 26 (range 23-32) weeks and the median birth weight was 938 (range 492-1450) g. Seven of the nine patients had severe symmetric injuries to the inferior cerebellar hemispheres, resulting in a pancake-like appearance of the residual upper cerebellum. Supratentorial lesions were also recognized: periventricular leukomalacia in seven; atrophy of the basal ganglia in two; and intraventricular hemorrhage in two. Importantly, the motor dysfunction was related to the reduction in the white matter volume and severity of basal ganglia atrophy, but not to the cerebellar injury. Four of the nine patients could walk without limitations despite extensive cerebellar disruption. Only four patients could speak meaningful words during the study and only one spoke two-word sentences. INTERPRETATION:The patients with cerebellar injury might have a communication handicap, rather than altered motor function. Prematurity-related cerebellar complications require more attention in terms of cognitive and speech function, in addition to neuromotor development.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Kobayashi S,Wakusawa K,Inui T,Tanaka S,Kobayashi Y,Onuma A,Haginoya Kdoi
10.1016/j.braindev.2015.01.009subject
Has Abstractpub_date
2015-10-01 00:00:00pages
858-63issue
9eissn
0387-7604issn
1872-7131pii
S0387-7604(15)00025-Xjournal_volume
37pub_type
杂志文章abstract：:Midazolam is a relatively new anticonvulsive agent in the benzodiazepine group. It has a short onset of duration and is practical for use, providing several alternatives such as intravenous, intramuscular, and intranasal routes. The buccal route could be an alternative choice for seizure control in an emergency settin...
journal_title：Brain & development
pub_type： 临床试验,杂志文章
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abstract：:Communicating hydrocephalus was inadvertently induced in a neonate by bilateral jugular vein catheterization. Removal of one catheter resulted in return to normal ventricular size within 14 days. The complication of hydrocephalus from bilateral jugular vein catheterization can be reversed by prompt removal of one cath...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：Brain & development
pub_type： 杂志文章
doi：10.1016/j.braindev.2007.08.011
更新日期：2008-04-01 00:00:00
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更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-07-01 00:00:00
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更新日期：2010-02-01 00:00:00
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journal_title：Brain & development
pub_type： 杂志文章,评审
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更新日期：2010-02-01 00:00:00
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journal_title：Brain & development
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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更新日期：2000-06-01 00:00:00
