Abstract:
:Spasms are a form of epileptic seizure typical of infancy. From a clinical point of view, the child presents a flexor-extensor movement involving the trunk and limbs and lasting about 1s. Although asymmetry can be present, the seizure involves both sides of the body. The ictal discharge most frequently associated with spasms in West syndrome (WS) is a diffuse triphasic slow high-amplitude wave and less frequently a low-amplitude brief rapid rhythm. The origin of the spasm in WS and classification as either partial or generalized seizure are the subject of much discussion. Factors supporting partial origin include: interictal electroencephalography (EEG) characterized by multifocal anomalies; high incidence of focal cortical lesions and remission of spasms following surgical removal of focal lesions. Factors supporting generalized origin are: clinical involvement of the entire body; mostly generalized ictal EEG pattern; existence of idiopathic cases and possibility of spasms immediately following a partial seizure like a particular form of secondary generalization. In our opinion, the categories of 'partial' and 'generalized' seizures are not applicable to spasms in WS. Sometimes the spasms in WS can be observed together with other types of partial or generalized seizures. Polygraphic recordings have demonstrated that despite being clinically similar, each spasm is different from the other because of a variable sequence in muscular contraction. These data support the peculiar nature of the spasm in WS that could be a subcortical phenomenon that requires a cortical trigger.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Vigevano F,Fusco L,Pachatz Cdoi
10.1016/s0387-7604(01)00284-4keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
467-72issue
7eissn
0387-7604issn
1872-7131pii
S0387760401002844journal_volume
23pub_type
杂志文章,评审abstract::Approximately 10% of patients with systemic lupus erythematosus (SLE) develop epileptic seizures. When occurring before the onset of generalized SLE, the seizures are mainly primary generalized. Accordingly, long-term treatment with anti-epileptic drugs may precipitate SLE, or epilepsy and SLE may both occur as manife...
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pub_type: 杂志文章,评审
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journal_title:Brain & development
pub_type: 杂志文章
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Brain & development
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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更新日期:2016-05-01 00:00:00
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.braindev.2006.01.009
更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
doi:
更新日期:1992-05-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Brain & development
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更新日期:2016-02-01 00:00:00
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journal_title:Brain & development
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更新日期:2021-01-12 00:00:00
abstract::The abnormalities of intracranial hemodynamics associated with strokelike episodes in MELAS are variable depend on the time phase from the onset of strokelike episodes and on the progression of the dementia state. To clarify the regional cerebral blood flows (rCBF) in the natural course of MELAS is very important to u...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2007.06.008
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract::Mutations in the methyl-CpG-binding protein 2 gene (MECP2) are identified in the majority of females with Rett syndrome (RTT), an X-linked dominant neurodevelopmental disorder. We searched for mutations by sequencing the MECP2 coding region in 45 sporadic cases (35 with classic RTT, eight with variant forms and two ma...
journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00