Development of a new screening tool for neuromotor development in children aged two - the neuromotor 5 min exam 2-year-old version (N5E2).

Abstract:

OBJECTIVE:As a new screening tool for neuromotor development in children aged two, we developed the Neuromotor 5 min Exam 2-year-old version (N5E2), which can be easily administered by pediatricians or primary care physicians. In this study, as an initial attempt to examine the utility of the N5E2, the inter-rater reliability on scoring for the individual items in this scale was assessed. METHODS:The participants of the study were 29 children (aged 1-5 years, mean age = 2.79) diagnosed with a variety of neuromotor/developmental disorders/high-risk conditions. Inter-rater reliability was examined on the following 11 items in the N5E2: (1) Retrieving a rolling ball, (2) Gait, (3) Toe-walking, (4) Asymmetries of posture and/or movement, (5) Age at unsupported walking, (6) Speaking in two-word understandable sentences, (7) Hypotonus, (8) Hypertonus, (9) Eye movement, (10) Vision problem, (11) Hearing problem. The items were administered to children by two pediatricians with different expertise and clinical experience, separately. RESULTS:The results showed that among the eleven items in the N5E2 examined, a high level of agreement (κ ≥ 0.60) was found on 4 items, and a moderate level of agreement (0.40 ≤ κ < 0.60) was found on 5 items. The level of agreement somewhat improved after the dichotomization of the score; using this format, a high level of rater agreement (κ ≥ 0.60) was found on 6 out of 11 items. The analyses also revealed high inter-rater reliability on the sum score of the 11 items (r = 0.84). CONCLUSIONS:The results suggest the possibility that this brief screening tool could be feasible in settings where clinicians' experience varies, based on its inter-rater reliability on individual items between the clinicians with different expertise and amount of clinical experiences.

journal_name

Brain Dev

journal_title

Brain & development

authors

Aoki S,Hashimoto K,Mezawa H,Hatakenaka Y,Yasumitsu-Lovell K,Suganuma N,Ohya Y,Wilson P,Fernell E,Kamio Y,Gillberg C

doi

10.1016/j.braindev.2018.01.012

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

445-451

issue

6

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(18)30032-9

journal_volume

40

pub_type

杂志文章
  • A case of congenital neuromuscular disease with uniform type 1 fibers.

    abstract::Congenital neuromuscular disease with uniform type 1 fibers is a rare form of congenital nonprogressive myopathy. We report a 3-year-old boy with this disease who showed delayed motor developmental milestones and recurrent acute respiratory failure. He obtained head control at 16 months, crawled at 17 months and sat a...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2005.06.008

    authors: Sakamoto HM,Yoshioka M,Tsuji M,Kuroki S,Higuchi Y,Nonaka I,Nishino I

    更新日期:2006-04-01 00:00:00

  • Reduction in cerebral blood flow volume in infants complicated with hypoxic ischemic encephalopathy resulting in cerebral palsy.

    abstract::Hypoxic ischemic brain can result in cerebral palsy, mental retardation, and learning disabilities in surviving children. The purpose of this study was to elucidate the cerebral blood flow volume in infants complicated with brain damage after the birth. Nine term infants with hypoxic ischemic encephalopathy and 41 nor...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2007.08.008

    authors: Fukuda S,Mizuno K,Kawai S,Kakita H,Goto T,Hussein MH,Daoud GA,Ito T,Kato I,Suzuki S,Togari H

    更新日期:2008-04-01 00:00:00

  • Theophylline impairs memory/learning in developing mice.

    abstract::We studied the relationship between theophylline and memory/learning using an elevated plus-maze test and measuring spontaneous locomotor activity in developing mice. There were no significant differences in transfer latency (TL) in 21-, 30- and 42-day-old mice in the acquisition trial, but theophylline significantly ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2003.12.008

    authors: Hirose M,Yokoyama H,Iinuma K

    更新日期:2004-10-01 00:00:00

  • Recent advances in non-invasive studies of higher brain functions.

    abstract::Recent advances in modern technologies have enabled us to investigate higher brain functions non-invasively in human subjects. These techniques include topographic analysis of the scalp-recorded electric potentials, recording of the magnetic field generated from the brain, measurement of regional cerebral blood flow c...

    journal_title:Brain & development

    pub_type: 杂志文章,评审

    doi:10.1016/0387-7604(93)90081-i

    authors: Shibasaki H

    更新日期:1993-11-01 00:00:00

  • Motor symptoms of the Rett syndrome: abnormal muscle tone, posture, locomotion and stereotyped movement.

    abstract::Amongst the motor, mental, cognitive and emotional symptoms of the Rett syndrome (RS) the motor symptoms stand out as the hallmark in analyzing the essential pathophysiology. Summarizing the motor symptoms and searching into the knowledge of relevant basic sciences, this report aims at stressing the pathophysiological...

    journal_title:Brain & development

    pub_type: 杂志文章,评审

    doi:

    authors: Nomura Y,Segawa M

    更新日期:1992-05-01 00:00:00

  • Peripheral nerve abnormalities in pediatric patients with spinal muscular atrophy.

    abstract::We examined the specific nerve conduction deficits distinguishing spinal muscular atrophy (SMA) subtypes I and II. Five SMA I patients (age, 0.2-1.1 years) and 10 SMA II patients (age, 1.0-2.8 years) were examined. Patients were compared to age-matched controls for motor and sensory conduction velocity (MCV and SCV) c...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2012.03.009

    authors: Yonekawa T,Komaki H,Saito Y,Sugai K,Sasaki M

    更新日期:2013-02-01 00:00:00

  • Ataxia with vitamin E deficiency and severe dystonia: report of a case.

    abstract::Mutation of the gene for alpha-tocopherol transfer protein causes ataxia with isolated vitamin E deficiency, a disorder usually stabilized or improved after vitamin E supplementation. Dystonia has rarely been described in ataxia with isolated vitamin E deficiency (AVED) patients. We present the case of a young boy wit...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(03)00054-8

    authors: Roubertie A,Biolsi B,Rivier F,Humbertclaude V,Cheminal R,Echenne B

    更新日期:2003-09-01 00:00:00

  • Late-onset Leigh syndrome with myoclonic epilepsy with ragged-red fibers.

    abstract::We report the case of a boy with myoclonic epilepsy with ragged-red fibers (MERRF) who had astatic seizures since 2 years of age and later developed ataxia, absence seizures, and myoclonus. Almost homoplasmic A8344G mutation of mitochondrial DNA (m.8344A>G mutation) was detected in lymphocytes. He developed late-onset...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2012.08.006

    authors: Monden Y,Mori M,Kuwajima M,Goto T,Yamagata T,Momoi MY

    更新日期:2013-06-01 00:00:00

  • Predictive value of the early clinical signs in Rett disorder.

    abstract::The British Isles Survey for Rett has registered 1,159 cases over up to 20 years. Indicators of health and severity, recorded at intervals throughout life, are drawn from clinical examinations, reports and postal questionnaires. This study aimed to establish the stability and predictive value of an early severity scor...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2004.10.007

    authors: Kerr AM,Prescott RJ

    更新日期:2005-11-01 00:00:00

  • PIGA related disorder as a range of phenotypes rather than two distinct subtypes.

    abstract::Patients with germline phosphatidylinositol glycan biosynthesis class A (PIGA) related disorder have historically been categorized into one of two distinct subtypes: a severe form which is often fatal, and a less severe form. However, the increasing number of cases with features indicative of both subtypes raise the p...

    journal_title:Brain & development

    pub_type:

    doi:10.1016/j.braindev.2019.10.002

    authors: Cash SJ,Mcgue BP,Reynolds TS,Crist ER

    更新日期:2020-02-01 00:00:00

  • Neurophysiological studies in the Leigh syndrome.

    abstract::We performed neurophysiological studies in 12 patients with the Leigh syndrome (6 pathologically confirmed and 6 clinically diagnosed). The results are compared with data derived from a literature survey of 173 Leigh syndrome patients. We found no positive contribution of neurophysiological studies towards the diagnos...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(86)80004-3

    authors: Van Erven PM,Colon EJ,Gabreëls FJ,Renier WO,Vingerhoets DM

    更新日期:1986-01-01 00:00:00

  • Breathing disorders in males with acquired encephalopathy.

    abstract::Six boys affected by acquired encephalopathy with an abnormal breathing pattern in wakefulness were studied. Polygraphic recordings showed two different patterns in our population. In two brothers a periodic breathing pattern was recorded in the awake and sleep states. In the others, central apneas with or without tac...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(12)80180-x

    authors: Cirignotta F,Sforza E,Burroni M,Zappella M,Lugaresi E

    更新日期:1990-01-01 00:00:00

  • Apnea associated with hypoxia in preterm infants: impact on cerebral blood volume.

    abstract::The present study analyzed changes in cerebral blood volume (CBV) during apnea associated with hypoxia compared to apnea without hypoxia. Hypoxia was defined as pulsoxymetric oxygen saturation <80%>10 s. The employed technique was near infrared spectroscopy combined with electrocardiogram, electroocologram, pulsoxymet...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(02)00121-3

    authors: Payer C,Urlesberger B,Pauger M,Müller W

    更新日期:2003-01-01 00:00:00

  • Convulsive syncope following placement of sphenoidal electrodes.

    abstract::Two cases of convulsive syncope following the insertion of sphenoidal electrodes are reported. The episodes occurred shortly after an uneventful insertion of the needle. Both patients exhibited behavioral arrest with loss of muscle tone, followed by flexor posturing, jerking of the extremities, then followed by what a...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(99)00006-6

    authors: DeToledo JC

    更新日期:1999-04-01 00:00:00

  • Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies.

    abstract::The long-term effectiveness of acetazolamide (AZA) and its side effects, especially the formation of renal calculi, were investigated in a prospective study when AZA was used as an adjunct to other antiepileptic drugs in the treatment of refractory epilepsies. The subjects comprised 37 patients aged from 1 to 17 years...

    journal_title:Brain & development

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0387-7604(02)00003-7

    authors: Katayama F,Miura H,Takanashi S

    更新日期:2002-04-01 00:00:00

  • Prognosis after withdrawal of antiepileptic drugs in childhood-onset cryptogenic localization-related epilepsies.

    abstract::The purpose of this study was to clarify the risk factors of relapse following discontinuation of AEDs in patients with childhood-onset cryptogenic localization-related epilepsies. The subjects were 82 patients who fulfilled the following criteria: (1) age at first visit of less than 15 years, (2) follow-up period of ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(03)00089-5

    authors: Ohta H,Ohtsuka Y,Tsuda T,Oka E

    更新日期:2004-01-01 00:00:00

  • Correlation between the M and F wave characteristics and the innervated muscle strength in spinal muscular atrophy.

    abstract::The purpose of this study is to elucidate the interrelation between the M and F wave characteristics of the median nerve and the grip power in patients with spinal muscular atrophy (SMA). The SMA patients showed decreased amplitudes of the M and F waves, decreased frequency of the F wave, and an increase of the F/M ra...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(97)00098-3

    authors: Imai T,Saito M,Matsumoto H,Ishikawa Y,Ishikawa Y,Minami R

    更新日期:1998-01-01 00:00:00

  • Dystrophin in control and mdx retina.

    abstract::To determine whether or not dystrophin really exists in the outer plexiform layer (OPL) of the retina, we studied control and mdx mice, using four kinds of polyclonal antibodies (DMDP-II, 60 kd, 30 kd and DMDP-IV) against dystrophin. Although control OPL showed a positive immunohistochemical reaction with all four ant...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(12)80123-9

    authors: Zhao J,Uchino M,Yoshioka K,Miyatake M,Miike T

    更新日期:1991-01-01 00:00:00

  • Developmental changes in autonomic responses are associated with future reward/punishment expectations: A study of sympathetic skin responses in the Markov decision task.

    abstract:OBJECTIVE:Autonomic nervous system activity is recognized as a major component of emotional responses. Future reward/punishment expectations depend upon the process of decision making in the frontal lobe, which is considered to play an important role in executive function. The aim of this study was to investigate the r...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2017.03.004

    authors: Hosaka H,Aoyagi K,Kaga Y,Kanemura H,Sugita K,Aihara M

    更新日期:2017-08-01 00:00:00

  • Nerve growth factor and the neurotrophic factor hypothesis.

    abstract::The discovery of nerve growth factor (NGF) over 40 years ago led to the formulation of the "Neurotrophic Factor Hypothesis". This hypothesis states that developing neurons compete with each other for a limited supply of a neurotrophic factor (NTF) provided by the target tissue. Successful competitors survive; unsucces...

    journal_title:Brain & development

    pub_type: 杂志文章,评审

    doi:10.1016/0387-7604(96)00051-4

    authors: Yuen EC,Howe CL,Li Y,Holtzman DM,Mobley WC

    更新日期:1996-09-01 00:00:00

  • Aquaporin-4 autoimmunity in a child without optic neuritis and myelitis.

    abstract::Neuromyelitis optica (NMO) is an inflammatory demyelinating disease with a poor prognosis that is characterized by inflammatory optic neuritis and myelitis. Although it is commonly misdiagnosed as multiple sclerosis (MS), distinguishing NMO from MS is important, as therapeutic approaches approved for MS are ineffectiv...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2014.03.015

    authors: Numata Y,Uematsu M,Suzuki S,Miyabayashi T,Oyama T,Kubota S,Itoh T,Hino-Fukuyo N,Takahashi T,Kure S

    更新日期:2015-01-01 00:00:00

  • Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.

    abstract:BACKGROUND:The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified. METHODS:Levels of 49 cytokines and chemokines, including osteopontin (OPN), were measured in serum and cerebrospinal fluid (CSF) of children with AE (n = 17) or febrile convulsion (FC; n = 8; control grou...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2019.11.002

    authors: Kawahara Y,Morimoto A,Oh Y,Furukawa R,Wakabayashi K,Monden Y,Osaka H,Yamagata T

    更新日期:2020-02-01 00:00:00

  • Respiratory function in handicapped children.

    abstract::The aim of this study was to evaluate respiratory function of severely handicapped children. Tidal volumes and respiratory rates were determined in a total of 130 children with different clinical motor abilities. Tidal volume of non-sitters (n = 39) was significantly lower than ambulators (n = 49) or sitters (n = 42) ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(12)80067-2

    authors: Ishida C,Fujita M,Umemoto H,Taneda M,Sanae N,Tazaki T

    更新日期:1990-01-01 00:00:00

  • Predictors of unprovoked seizure after febrile seizure: short-term outcomes.

    abstract:INTRODUCTION:We performed this study to confirm the known risk factors and to identify possible new risk factors for subsequent unprovoked seizure after febrile seizure (FS) on Jeju Island, South Korea. METHODS:A population-based retrospective study of 204 children with FS, whose first FS developed between March 2003 ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2014.06.003

    authors: Hwang G,Kang HS,Park SY,Han KH,Kim SH

    更新日期:2015-03-01 00:00:00

  • Ictal electroencephalographic findings of neonatal seizures in preterm infants.

    abstract::The aim of this study is to clarify the characteristics of ictal EEG findings of neonatal seizures in preterm infants. Seizures associated with ictal EEG changes were recognized in nine infants with gestational age of less than 37 weeks. Propagation, migration, shifting, changes in morphology of ictal EEG discharges w...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2007.08.011

    authors: Okumura A,Hayakawa F,Kato T,Itomi K,Maruyama K,Kubota T,Suzuki M,Kidokoro H,Watanabe K

    更新日期:2008-04-01 00:00:00

  • Cortical reflex myoclonus associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS): a case report.

    abstract::A 9-year-old female MELAS patient with myoclonus is reported, with emphasis on the results of electrophysiological studies of the myoclonus. At age 5 years she experienced a stroke-like episode, and a diagnosis of MELAS was made at age 6 years on the basis of muscle biopsy findings. At age 9 years spontaneous and segm...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(12)80244-0

    authors: Saitoh S,Kohsaka S,Mizukami S,Kajii N

    更新日期:1992-07-01 00:00:00

  • Missense mutation of the sodium channel gene SCN2A causes Dravet syndrome.

    abstract::Mutations of the gene encoding the alpha2 subunit of the neuronal sodium channel, SCN2A, have been found in benign familial neonatal-infantile seizures (BFNIS). In Dravet syndrome, only one nonsense mutation of SCN2A was identified, while hundreds of mutations were found in the paralogue gene, SCN1A, which encodes the...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2009.08.009

    authors: Shi X,Yasumoto S,Nakagawa E,Fukasawa T,Uchiya S,Hirose S

    更新日期:2009-11-01 00:00:00

  • Syndrome of septo-optic-pituitary dysplasia: the clinical spectrum.

    abstract::Septo-optic-pituitary dysplasia is a syndrome characterized by abnormalities of midline brain structures, optic nerve hypoplasia, and congenital hypothalamic-pituitary insufficiency. Four infants, diagnosed as having clinical variations of this disorder, are described. The first had agenesis of the septum pellucidum a...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(86)80075-4

    authors: Morishima A,Aranoff GS

    更新日期:1986-01-01 00:00:00

  • Brain stem and spinal cord impairment in Rett syndrome: somatosensory and auditory evoked responses investigations.

    abstract::Six females with Rett syndrome (RS)--all seriously motor disabled with clinical symptomatology indicating not only brain but also spinal cord impairment--were investigated using auditory and somatosensory evoked responses techniques. In all patients the responses representing the pathways through the upper spinal cord...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(87)80076-1

    authors: Badr GG,Witt-Engerström I,Hagberg B

    更新日期:1987-01-01 00:00:00

  • Congenital muscular dystrophy (non-Fukuyama type) in Turkey: a clinical and pathological evaluation.

    abstract::Congenital muscular dystrophy (CMD) is a heterogenous group of disorders. In the majority of cases the intelligence is preserved, which comprises the classic "occidental" (type 1) form. This type appears to be prevalent in the west. We report a five-case series in Turkey, confirming its geographical distribution. ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(89)80066-x

    authors: Topaloğlu H,Yalaz K,Renda Y,Kale G,Cağlar M,Göğüş S

    更新日期:1989-01-01 00:00:00