Abstract:
:Antibiotics have been proposed as supplements in re-feeding programmes for malnourished children. A review of paediatric literature showed that growth promotion by antibiotics, when it was observed, was mostly mediated by its anti-infective properties. Despite the widespread use of antibiotics as growth promoters in animal rearing, the available evidence again points to the suppression of infections as the underlying mechanism. Under controlled hygienic conditions, growth promotion was frequently not observed. Models for 'sub-inhibitory' antibiotic effects on gut bacteria have been proposed, and direct antibiotic effects on host physiology are accumulating. Human gut microbiota analyses in malnourished children (restricted to stool as convenience samples) displayed developmental immaturity of the gut microbiota and growth deficits that were only transiently ameliorated by nutritional interventions. These studies need to be complemented by microbiota analysis in the upper small intestine where bacterial overgrowth, frequently reported in people of the developing world, may directly compete with nutrient absorption by the human host. So far, however, the available medical and veterinary literature suggests that the growth promoting effect of antibiotics mostly works through prevention of infection and a concomitant decrease of the caloric burden of an inflammatory response.
journal_name
Environ Microbioljournal_title
Environmental microbiologyauthors
Brüssow Hdoi
10.1111/1462-2920.12786subject
Has Abstractpub_date
2015-07-01 00:00:00pages
2216-27issue
7eissn
1462-2912issn
1462-2920journal_volume
17pub_type
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journal_title:Environmental microbiology
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journal_title:Environmental microbiology
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journal_title:Environmental microbiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Environmental microbiology
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journal_title:Environmental microbiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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