Does quorum sensing interference affect the fitness of bacterial pathogens in the real world?

Abstract:

:Many bacterial pathogens rely on quorum sensing to control virulence gene expression. Based on numerous experiments conducted under well-defined conditions, quorum sensing interference is considered as a promising strategy to tackle infections and thus might have the potential to (partially) replace antibiotics. Despite the promising results in well-defined (artificial) laboratory experiments, there still is a lack of knowledge with respect to the impact of quorum sensing interference on the fitness of pathogens in more realistic scenarios, including interactions with a host, the external environment and complex microbial communities. In this article, we critically evaluate the current knowledge with respect to these three facets of the real world that can affect the fitness of quorum sensing bacterial pathogens. We argue that further research is needed in order to determine how these factors interplay with quorum sensing and to what extent they can influence the selective pressure that might be exerted by quorum sensing interference (and thus determine the risk of resistance development against quorum sensing interference). This kind of information is indispensable in order to optimize quorum sensing interference-based therapeutic strategies.

journal_name

Environ Microbiol

authors

Liu Y,Qin Q,Defoirdt T

doi

10.1111/1462-2920.14446

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

3918-3926

issue

11

eissn

1462-2912

issn

1462-2920

journal_volume

20

pub_type

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