Abstract：
:Pax family genes encode a class of transcription factors that regulate various developmental processes. To shed light on the evolutionary history of these genes in Panarthropoda (Onychophora + Tardigrada + Arthropoda), we analyzed the Pax repertoire in the embryonic and adult transcriptomes of the onychophoran Euperipatoides rowelli. Our data revealed homologs of all five major bilaterian Pax subfamilies in this species, including Pax2/5/8, Pax4/6, Pox-neuro, Pax1/9/Pox-meso, and Pax3/7. In addition, we identified a new Pax member, pax-α, which does not fall into any other known Pax subfamily but instead clusters in the heterogenic Pax-α/β clade containing deuterostome, ecdysozoan, and lophotrochozoan gene sequences. These findings suggest that the last common bilaterian ancestor possessed six rather than five Pax genes, which have been retained in the panarthropod lineage. The expression data of Pax orthologs in the onychophoran embryo revealed distinctive patterns, some of which might be related to their ancestral roles in the last common panarthropod ancestor, whereas others might be specific to the onychophoran lineage. The derived roles include, for example, an involvement of pax2/5/8, pox-neuro, and pax3/7 in onychophoran nephridiogenesis, and an additional function of pax2/5/8 in the formation of the ventral and preventral organs. Furthermore, our transcriptomic analyses suggest that at least some Pax genes, including pax6 and pax-α, are expressed in the adult onychophoran head, although the corresponding functions remain to be clarified. The remarkable diversity of the Pax expression patterns highlights the functional and evolutionary plasticity of these genes in panarthropods.
journal_name
Evol Devjournal_title
Evolution & developmentauthors
Franke FA,Schumann I,Hering L,Mayer Gdoi
10.1111/ede.12110subject
Has Abstractpub_date
2015-01-01 00:00:00pages
3-20issue
1eissn
1520-541Xissn
1525-142Xjournal_volume
17pub_type
杂志文章abstract：:Paxbeta is a novel gene family restricted to the bilaterian superphylum Lophotrochozoa. The Paxbeta paired domain is highly diverged from other bilaterian Pax genes, and we were unable to identify an unambiguous sister-group by phylogenetic sequence analysis. However, conservation of a paired domain intron suggests th...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2009.00376.x
更新日期：2009-11-01 00:00:00
abstract：:Phenotypes of organisms are not determined completely genetically, but vary according to environmental factors (phenotypic plasticity). Some organisms express several discrete adaptive phenotypes (polyphenism). Social insects possess a few types of individuals (castes) in their colonies, to which specific tasks are al...
journal_title：Evolution & development
pub_type： 杂志文章,评审
doi：10.1111/j.1525-142X.2005.05014.x
更新日期：2005-03-01 00:00:00
abstract：:The development of the coeloms is described in an echinoid with an abbreviated larval development and shows the early morphogenesis of the coeloms of the adult stage. The development is described from images obtained by laser scanning confocal microscopy. The development in Heliocidaris erythrogramma is asymmetric wit...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2011.00492.x
更新日期：2011-07-01 00:00:00
abstract：:Using the Hawaiian acorn worm, Ptychodera flava, we began molecular studies on the development of hemichordates, a phylum previously unstudied at this level. Here we review results garnered from the examination of a few specific genes selected to help understand the evolution of vertebrate structures. These studies su...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2001.01050.x
更新日期：2001-11-01 00:00:00
abstract：:Myogenesis of two representatives of Platyhelminthes, Stylostomum sanjuania and Pseudoceros canadensis, was followed from egg deposition until well-differentiated free-swimming larval stages, using F-actin staining and confocal laserscanning microscopy. Zonulae adhaerentes are the only structures to stain before 50% o...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2010.00405.x
更新日期：2010-03-01 00:00:00
abstract：:The mouse mandible has long served as a model system for studying the development and evolution of complex morphological structures. We used the methods of geometric morphometrics to reassess the hypothesis that the mandible consists of two separate modules: an anterior part bearing the teeth and a posterior part with...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2003.03057.x
更新日期：2003-09-01 00:00:00
abstract：:The mocker swallowtail, Papilio dardanus, has a female-limited polymorphic mimicry. This polymorphism is controlled by allelic variation at a single locus with at least 11 alleles. Many of the alternative morphs are accurate mimics of different species of distasteful butterflies. Geneticists have long been interested ...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2003.03063.x
更新日期：2003-11-01 00:00:00
abstract：:In many respects, reptile hatchlings are fully functional, albeit miniature, adults. This means that the adult morphology must emerge during embryonic development. This insight emphasizes the connection between the mechanisms that generate phenotypic variation during embryonic development and the action of selection o...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12221
更新日期：2017-05-01 00:00:00
abstract：:Homeobox transcription factors are commonly involved in developmental regulation in diverse eukaryotes, including plants, animals, and fungi. The origin of novel homeobox genes is thought to have contributed to many evolutionary innovations in animals. We perform a molecular phylogenetic analysis of cnox2, the best st...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2003.03041.x
更新日期：2003-07-01 00:00:00
abstract：:Repeated tooth initiation occurs often in nonmammalian vertebrates (polyphyodontism), recurrently linked with tooth shedding and in a definite order of succession. Regulation of this process has not been genetically defined and it is unclear if the mechanisms for constant generation of replacement teeth (secondary den...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2006.00118.x
更新日期：2006-09-01 00:00:00
abstract：:The phylogenetic positions of frogs, salamanders, and caecilians have been difficult to establish. Data matrices based primarily on Paleozoic taxa support a monophyletic origin of all Lissamphibia but have resulted in widely divergent hypotheses of the nature of their common ancestor. Analysis that concentrates on the...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2003.03038.x
更新日期：2003-05-01 00:00:00
abstract：:Geophilomorph centipedes exhibit a number of unique characteristics that make them of particular developmental and evolutionary interest. Segment numbers in geophilomorphs are higher than in any other centipedes, ranging from 27 to 191. They may be constant within a species, presenting in extreme form the "counting" p...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142x.2004.04016.x
更新日期：2004-03-01 00:00:00
abstract：:The full-length sequence and developmental expression of amphioxus AmphiFoxE4 are described. Transcripts of the gene are first detected in the pharyngeal endoderm, where the club-shaped gland is forming and subsequently in the definitive gland itself. AmphiFoxE4 is closely related to vertebrate genes encoding the thyr...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2002.01057.x
更新日期：2002-01-01 00:00:00
abstract：:Morphological transformations can be generated by evolutionary changes in the sequence of developmental events. In this study, we examined the evolutionary dynamics of the developmental sequence on a macroevolutionary scale in teleosts. Using the information from previous reports describing the development of 31 speci...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12288
更新日期：2019-05-01 00:00:00
abstract：:Stinging cells called cnidocytes are a defining trait of the cnidarians (sea anemones, corals, jellyfish, and their relatives). In hydrozoan cnidarians such as Hydra, cnidocytes develop from interstitial stem cells set aside in the ectoderm. It is less clear how cnidocytes develop outside the Hydrozoa, as other cnidar...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12278
更新日期：2019-03-01 00:00:00
abstract：:The proximo-distal axis of the arthropod leg is patterned by mutually antagonistic developmental expression domains of the genes extradenticle, homothorax, dachshund, and Distal-less. In the deutocerebral appendages (the antennae) of insects and crustaceans, the expression domain of dachshund is frequently either abse...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12005
更新日期：2012-11-01 00:00:00
abstract：:Mammalian heterodont dentition is differentiated into incisors, canines, premolars, and molars in the mesial-distal direction, in both the upper and lower jaws. Although all the lower teeth are rooted in the mandible, the upper incisors are rooted in the premaxilla and the upper canine and the teeth behind it are in t...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12116
更新日期：2015-03-01 00:00:00
abstract：:The regulation of floral organ identity was investigated using a forward genetic approach in five floral homeotic mutants of Thalictrum, a noncore eudicot. We hypothesized that these mutants carry defects in the floral patterning genes. Mutant characterization comprised comparative floral morphology and organ identity...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/ede.12357
更新日期：2020-11-12 00:00:00
abstract：:Amphioxus probably has only a single gene (AmphiPax3/7) in the Pax3/7 subfamily. Like its vertebrate homologs (Pax3 and Pax7), amphioxus AmphiPax3/7 is probably involved in specifying the axial musculature and muscularized notochord. During nervous system development, AmphiPax3/7 is first expressed in bilateral antero...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.1999.99019.x
更新日期：1999-11-01 00:00:00
abstract：:Homeobox gene database (HomeoDB), a manually curated database of homeobox genes and their classification, has been well received since its release in 2008. Here, we report HomeoDB2, an expansion and improvement of the original database that provides greater functionality for the user. HomeoDB2 includes all homeobox lo...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2011.00513.x
更新日期：2011-11-01 00:00:00
abstract：:We analyzed a comprehensive data set of ossification sequences including seven marsupial, 13 placental and seven sauropsid species. Data are provided for the first time for two major mammalian clades, Chiroptera and Soricidae, and for two rodent species; the published sequences of three species were improved with addi...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2008.00267.x
更新日期：2008-09-01 00:00:00
abstract：:Molecular and morphological data sets have yielded conflicting phylogenies for the Metazoa. So far, no general explanation for the existence of this conflict has been suggested. However, I believe that a neglected aspect of metazoan cladistics has introduced a systematic and substantial bias into morphological phyloge...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2004.04045.x
更新日期：2004-09-01 00:00:00
abstract：:It has recently been shown that the three metazoan superphyla that are recognized on the basis of 18S rDNA phylogenies--ecdysozoans, lophotrochozoans, and deuterostomes--each have characteristic Hox genes. This observation has been taken further, and these "signature" Hox genes have been looked for in taxa of uncertai...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2000.00075.x
更新日期：2000-11-01 00:00:00
abstract：:Organizers of the symposium Starting from Fins: Parallelism in the Evolution of Limbs and Genitalia intended it 1) to begin debates and discussions about parallelism, serial homology and transitions in development, as well as evolution of gene function and theories of origins and 2) to examine closely the potential si...
journal_title：Evolution & development
pub_type：
doi：10.1046/j.1525-142x.2002.01067.x
更新日期：2002-03-01 00:00:00
abstract：:Null mutations in the Drosophila melanogaster homeotic gene proboscipedia (pb) cause transformation of the adult labial palps to legs. The similar phenotype produced by mutations in the Tribolium castaneum homeotic complex (HOMC) gene maxillopedia (mxp) has led to suggestions that the two genes may be orthologous. We ...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1046/j.1525-142x.2000.00055.x
更新日期：2000-05-01 00:00:00
abstract：:LEAFY HULL STERILE1 (LHS1) is an MIKC-type MADS-box gene in the SEPALLATA class. Expression patterns of LHS1 homologs vary among species of grasses, and may be involved in determining palea and lemma morphology, specifying the terminal floret of the spikelet, and sex determination. Here we present LHS1 expression data...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2006.00100.x
更新日期：2006-05-01 00:00:00
abstract：:Jaw shedding and replacement of Diopatra aciculata (Onuphidae, Eunicida), by the same process as arthropod molting, involving apolysis and ecdysis, is described here. These observations suggest that molting has either evolved convergently in eunicidan polychaetes and ecdysozoans or it was present in the last ecdysozoa...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2005.05039.x
更新日期：2005-07-01 00:00:00
abstract：:Anuran development is usually described using model species, most notably Xenopus laevis and Rana pipiens. We describe the development of the East African Reed Frog, Hyperolius puncticulatus, a species displaying development that is highly divergent from the "classic" anuran developmental pattern. Although having smal...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142x.1999.t01-3-.x
更新日期：1999-07-01 00:00:00
abstract：:An ongoing challenge to evolutionary developmental biology is to understand how developmental evolution on the level of populations and closely related species relates to macroevolutionary transformations and the origin of morphological novelties. Here we explore the developmental basis of beetle horns, a morphologica...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2005.05020.x
更新日期：2005-05-01 00:00:00
abstract：:How do proteins evolve while maintaining their function? Previous studies find a highly stringent structure/function relationship between the Drosophila melanogaster testis-specific tubulin beta2 and the spermtail axoneme, such that small changes in the beta2 protein render it unable to generate a motile axoneme. This...
journal_title：Evolution & development
pub_type： 杂志文章
doi：10.1111/j.1525-142X.2006.05072.x
更新日期：2006-01-01 00:00:00
