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Stemistry: the control of stem cells in situ using chemistry.

Abstract：

:A new paradigm for drug research has emerged, namely the deliberate search for molecules able to selectively affect the proliferation, differentiation, and migration of adult stem cells within the tissues in which they exist. Recently, there has been significant interest in medicinal chemistry toward the discovery and design of low molecular weight molecules that affect stem cells and thus have novel therapeutic activity. We believe that a successful agent from such a discover program would have profound effects on the treatment of many long-term degenerative disorders. Among these conditions are examples such as cardiovascular decay, neurological disorders including Alzheimer's disease, and macular degeneration, all of which have significant unmet medical needs. This perspective will review evidence from the literature that indicates that discovery of such agents is achievable and represents a worthwhile pursuit for the skills of the medicinal chemist.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Davies SG,Kennewell PD,Russell AJ,Seden PT,Westwood R,Wynne GM

doi

10.1021/jm500838d

subject

Has Abstract

pub_date

2015-04-09 00:00:00

pages

2863-94

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

58

pub_type

杂志文章,评审

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