A review on the effects of PBDEs on thyroid and reproduction systems in fish.

Abstract:

:The objective of this review was to summarize and discuss the effects of Polybrominated diphenyl ethers (PBDEs) on thyroid and reproduction systems in fish. We reviewed the evidences and mechanisms for PBDEs-induced thyroid and reproduction disruption, as well as the cross-talk between the two systems in fish. In thyroid disruption, we mainly paid attention to the effects of PBDEs on hypothalamic-pituitary-thyroid (HPT) axis, thyroid hormones (THs) transport and metabolism, thyroid receptors (TRs) and thyroid follicle histology. In reproduction disruption, we focused on the effects of PBDEs on steroid hormone production, expression of genes involved in steroidogenesis, and gonadal development. Despite that there is an interaction between thyroid and reproductive systems in fish, it is still remains unclear that PBDE-induced reproductive impairments are caused by direct effects on hypothalamic-pituitary-gonadal (HPG) functioning or by indirect action through cross-talk between the two systems. Future studies are needed to explore the relationships between reproductive toxicity and thyroid system disruption after PBDEs exposure.

journal_name

Gen Comp Endocrinol

authors

Yu L,Han Z,Liu C

doi

10.1016/j.ygcen.2014.12.010

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

64-73

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(14)00473-0

journal_volume

219

pub_type

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