Abstract:
:The objective of this review was to summarize and discuss the effects of Polybrominated diphenyl ethers (PBDEs) on thyroid and reproduction systems in fish. We reviewed the evidences and mechanisms for PBDEs-induced thyroid and reproduction disruption, as well as the cross-talk between the two systems in fish. In thyroid disruption, we mainly paid attention to the effects of PBDEs on hypothalamic-pituitary-thyroid (HPT) axis, thyroid hormones (THs) transport and metabolism, thyroid receptors (TRs) and thyroid follicle histology. In reproduction disruption, we focused on the effects of PBDEs on steroid hormone production, expression of genes involved in steroidogenesis, and gonadal development. Despite that there is an interaction between thyroid and reproductive systems in fish, it is still remains unclear that PBDE-induced reproductive impairments are caused by direct effects on hypothalamic-pituitary-gonadal (HPG) functioning or by indirect action through cross-talk between the two systems. Future studies are needed to explore the relationships between reproductive toxicity and thyroid system disruption after PBDEs exposure.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Yu L,Han Z,Liu Cdoi
10.1016/j.ygcen.2014.12.010subject
Has Abstractpub_date
2015-08-01 00:00:00pages
64-73eissn
0016-6480issn
1095-6840pii
S0016-6480(14)00473-0journal_volume
219pub_type
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