Abstract:
:The chemical versatility of the indole nucleus still inspires the pharmaceutical research to develop innovative suitable indole based drugs. The present work is an overview of the use and application of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan (Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active drugs for a simpler delivery to the patients.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Aiello F,Valacchi Gdoi
10.2174/1568026614666141203142926subject
Has Abstractpub_date
2014-01-01 00:00:00pages
2576-89issue
22eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-63793journal_volume
14pub_type
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