Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents.

Abstract:

:Histone deacetylase (HDAC) inhibitors constitute a novel and growing class of anticancer agents that function by altering intracellular patterns of histone acetylation, the so-called epigenetic "histone code," thereby producing changes in cell cycle arrest, differentiation, and/or apoptosis in tumor cells. This overview describes the chemistry and preliminary characterization of recently disclosed molecules in three major classes of HDAC inhibitors: hydroxamic acids, 2-amino- benzanilides, and cyclic peptides. In addition, results from recent clinical trials on isotype-selective HDAC inhibitors are reviewed. It is clear from the plethora of new molecules and the encouraging results from clinical trials that HDAC inhibitors hold a great deal of promise, particularly as add-on therapy, for the treatment of a variety of solid and hematologic cancers.

journal_name

Curr Top Med Chem

authors

Moradei O,Vaisburg A,Martell RE

doi

10.2174/156802608784911581

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

841-58

issue

10

eissn

1568-0266

issn

1873-4294

journal_volume

8

pub_type

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