Abstract:
:Colorectal cancer (CRC) is a slow-developing cancer (10-15 years) with one of the highest frequencies in the world's population. Many countries have implemented various CRC screening programs, but have not achieved the desired compliance. Colonoscopy - considered the gold standard for CRC screening - has its limitations as well as the other techniques used, such as irrigoscopy, sigmoidoscopy, fecal blood and hemoglobin tests. The biomarker septin 9 has been found to be hypermethylated in nearly 100% of tissue neoplasia specimens and detected in circulating DNA fractions of CRC patients. A commercially available assay for septin 9 has been developed with moderate sensitivity (∼70%) and specificity (∼90%) and a second generation assay, Epi proColon 2.0 (Epigenomics AG), shows increased sensitivity (∼92%). The performance of the assay proved to be independent of tumor site and reaches a high sensitivity of 77%, even in early cancer stages (I and II). Furthermore, septin 9 was recently used in follow-up studies for detection of early recurrence of CRC. This article evaluates the opportunities, known limitations and future perspectives of the recently introduced Epi proColon(®) 2.0 test, which is based on the detection of aberrantly methylated DNA of the v2 region of the septin 9 gene in plasma.
journal_name
Expert Rev Mol Diagnjournal_title
Expert review of molecular diagnosticsauthors
Molnár B,Tóth K,Barták BK,Tulassay Zdoi
10.1586/14737159.2015.975212subject
Has Abstractpub_date
2015-02-01 00:00:00pages
171-84issue
2eissn
1473-7159issn
1744-8352journal_volume
15pub_type
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journal_title:Expert review of molecular diagnostics
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journal_title:Expert review of molecular diagnostics
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pub_type: 杂志文章,评审
doi:10.1080/14737159.2016.1217159
更新日期:2016-09-01 00:00:00
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pub_type: 面试
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doi:10.1586/14737159.5.1.31
更新日期:2005-01-01 00:00:00
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
doi:10.1586/14737159.2016.1126511
更新日期:2016-01-01 00:00:00
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
doi:10.1586/14737159.2015.1091729
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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