Metabolomics-based methods for early disease diagnostics.

abstract：:Among nucleic acid analytical methods, high-resolution melting analysis is gaining more and more attention. High-resolution melting provides simple, homogeneous solutions for variant scanning and genotyping, addressing the needs of today's overburdened laboratories with rapid turnaround times and minimal cost. The fle...

journal_title：Expert review of molecular diagnostics

authors： Montgomery JL,Sanford LN,Wittwer CT

更新日期：2010-03-01 00:00:00

abstract：:Background: Recently, considerable evidence pointed out monocyte to high-density lipoprotein ratio (MHR) is highly related to inflammatory related diseases. We aim to explore the level of MHR in acute aortic dissection (AAD) patients and determine whether MHR can be a novel diagnostic marker of AAD. Research design an...

journal_title：Expert review of molecular diagnostics

authors： Du X,Zhang S,Xu J,Xiang Q,Tian F,Li X,Guo L,Zhu L,Qu P,Fu Y,Tan Y,Gui Y,Wen T,Godinez B,Liu L MD, PHD

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Familial hypercholesterolemia (FH) is a common genetic cause of premature coronary heart disease that is widely underdiagnosed and undertreated. To improve the identification of FH and initiate timely and appropriate treatment strategies, genetic testing is becoming increasingly offered worldwide as a cent...

journal_title：Expert review of molecular diagnostics

authors： Iacocca MA,Hegele RA

更新日期：2017-07-01 00:00:00

abstract：:The microscopic pathology of Hodgkin lymphoma has been recognized for well over a century; however, only in the past 15 years has the enigmatic nature of this peculiar neoplasm been somewhat unraveled. This has been accomplished via a combination of the acquisition, via microdissection, of the prototypically rare mali...

journal_title：Expert review of molecular diagnostics

authors： Roullet MR,Bagg A

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The aim of this manuscript was to explore the molecular basis and identify novel biomarkers for the diagnosis and prognosis of patients with chronic disorder of consciousness. METHODS:A coupled isobaric tag for relative and absolute quantitation-based approach was used to screen differentially expressed pro...

journal_title：Expert review of molecular diagnostics

authors： Bao W,He F,Gao J,Meng F,Zou H,Luo B

更新日期：2018-03-01 00:00:00

abstract：:A successful biodefense strategy relies upon any combination of four approaches. A nation can protect its troops and citizenry first by advanced mass vaccination, second, by responsive ring vaccination, and third, by post-exposure therapeutic treatment (including vaccine therapies). Finally, protection can be achieved...

journal_title：Expert review of molecular diagnostics

authors： Weinberg S

更新日期：2004-11-01 00:00:00

abstract：:Tuberculosis (TB) is the most deadly infectious disease in the world. TB control relies on passive case findings and targeted treatment of latently infected individuals at high risk of disease progression. Tuberculin skin testing (TST) is conventionally used for detection of TB infection. Recently, blood assays measur...

journal_title：Expert review of molecular diagnostics

authors： Bocchino M,Bellofiore B,Matarese A,Galati D,Sanduzzi A

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:A reliable liver autoimmune serology for the diagnosis of primary biliary cholangitis (PBC) is of particular importance. Recognition of patients at early stages and prompt treatment initiation may alter the outcome, slow progression, delays liver failure, and improves survival. AREAS COVERED:In this revie...

journal_title：Expert review of molecular diagnostics

authors： Gatselis NK,Dalekos GN

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a highly heterogenous disease influenced by different molecular, anatomic, and physiologic imbalances. Some of the bottlenecks for enhanced diagnosis and therapeutic assessment are the lack of validated biomarkers and early diagnosis tools. In this narrative review, we analyze the po...

journal_title：Expert review of molecular diagnostics

authors： Casal-Beiroa P,González P,Blanco FJ,Magalhães J

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require so...

journal_title：Expert review of molecular diagnostics

authors： Sher M,Zhuang R,Demirci U,Asghar W

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Minimally invasive methods will augment the clinical approach for establishing the diagnosis or monitoring treatment response of central nervous system tumors. Liquid biopsy by blood or cerebrospinal fluid sampling holds promise in this regard. Areas covered: In this literature review, the authors highligh...

journal_title：Expert review of molecular diagnostics

authors： Shankar GM,Balaj L,Stott SL,Nahed B,Carter BS

更新日期：2017-10-01 00:00:00

abstract：:There is great interest in the development of noninvasive methods for imaging angiogenic responses. Strategies for assessing angiogenesis have primarily relied on measuring perfusion-related characteristics, such as total blood flow or microvascular volume, or detecting abnormal vascular permeability. Techniques are n...

journal_title：Expert review of molecular diagnostics

authors： Heppner P,Lindner JR

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The prognostic significance of serum gamma-glutamyl transferase (GGT) level at diagnosis in patients with metastatic non-small lung cancer (NSCLC) is not clear. We aimed to assess the relationship between serum GGT level and overall survival (OS) and progression-free survival (PFS) in this patient population...

journal_title：Expert review of molecular diagnostics

authors： Bozkaya Y,Yazıcı O

更新日期：2019-03-01 00:00:00

abstract：:In recent years, quantitative real-time PCR tests have been extensively developed in clinical microbiology laboratories for routine diagnosis of infectious diseases, particularly bacterial diseases. This molecular tool is well-suited for the rapid detection of bacteria directly in clinical specimens, allowing early, s...

journal_title：Expert review of molecular diagnostics

authors： Maurin M

更新日期：2012-09-01 00:00:00

abstract：:Finding early-stage lung cancer where there is a higher chance for patient survival remains a major healthcare challenge. Low-dose spiral computed tomography for high-risk patients can increase the detection of cancers with certain tradeoffs, such as increased radiation exposure and surgical risks for false-positive c...

journal_title：Expert review of molecular diagnostics

authors： Palma JF,Das P,Liesenfeld O

更新日期：2016-01-01 00:00:00

abstract：:Next-generation sequencing, also known as massively paralleled sequencing, offers an unprecedented opportunity to study disease mechanisms of inherited retinal dystrophies: a dramatic change from a few years ago. The specific involvement of the retina and the manageable number of genes to sequence make inherited retin...

journal_title：Expert review of molecular diagnostics

authors： Chiang JP,Lamey T,McLaren T,Thompson JA,Montgomery H,De Roach J

更新日期：2015-01-01 00:00:00

abstract：:Biomarkers complement clinical assessment, electrocardiogram and cardiac imaging in the diagnosis, risk stratification, triage and management of patients with suspected acute cardiovascular diseases. While there is broad consensus that cardiac troponin is the preferred biomarker in clinical practice for the detection ...

journal_title：Expert review of molecular diagnostics

authors： Rubini Gimenez M,Twerenbold R,Mueller C

更新日期：2015-04-01 00:00:00

abstract：:The huge parallel sequencing capabilities of next generation sequencing technologies have made them the tools of choice to characterize genomic aberrations for research and diagnostic purposes. For clinical applications, screening the whole genome or exome is challenging owing to the large genomic area to be sequenced...

journal_title：Expert review of molecular diagnostics

authors： Ballester LY,Luthra R,Kanagal-Shamanna R,Singh RR

更新日期：2016-01-01 00:00:00

abstract：:Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, in different parts of the peritoneal cavity. It affects up to 10% of reproductive-age women and up to 50% of women with infertility. Surgical diagnosis of endometriosis is still the gold standard, with no diagnostic biomarker...

journal_title：Expert review of molecular diagnostics

authors： Rižner TL

更新日期：2015-04-01 00:00:00

abstract：:The capacity to use molecular techniques to establish the genetic diagnoses of the autosomal dominant ataxias has revolutionized the field. It is now possible to systematically classify these disorders according to the nature of the causative mutation, with implications for diagnostic testing, analysis of pathogenesis...

journal_title：Expert review of molecular diagnostics

authors： Margolis RL

更新日期：2003-11-01 00:00:00

abstract：:Introduction: This review concerns biomarkers of blood activation and their measurement in plasma, as described in the literature up to 2019, and from our personal experience. How their measurement can be informative and useful, for research studies or for diagnostic applications, is presented and discussed.Areas cove...

journal_title：Expert review of molecular diagnostics

authors： Amiral J

更新日期：2020-01-01 00:00:00

abstract：:Non-targeted identification of microbes is now possible directly in biological samples, based on whole-genome-NGS (WG-NGS) techniques that allow deep sequencing of nucleic acids, data mining and sorting out of sequences of pathogens without any a priori hypothesis. WG-NGS was first only used as a research tool due to ...

journal_title：Expert review of molecular diagnostics

authors： Lecuit M,Eloit M

更新日期：2015-01-01 00:00:00

abstract：:Interview with Professor Manuel Salto-Tellez by Claire Raison, Commissioning Editor Professor Manuel Salto-Tellez of Queen's University, Belfast, Northern Ireland is an expert histopathologist and molecular diagnostician. Professor Salto-Tellez is a lead investigator at the Northern Ireland Molecular Pathology Laborat...

journal_title：Expert review of molecular diagnostics

authors： Salto-Tellez M,Raison C

更新日期：2015-05-01 00:00:00

abstract：:Acute intermittent porphyria (AIP) is an inherited metabolic disease with an autosomal dominant pattern of inheritance. The disease is caused by a partial deficiency of porphobilinogen deaminase (PBGD) in heme biosynthesis. Since biochemical measurements of patients and their healthy relatives overlap, the diagnosis o...

journal_title：Expert review of molecular diagnostics

authors： Kauppinen R

更新日期：2004-03-01 00:00:00

abstract：:For most diseases, better biomarkers are urgently needed to enable (early) detection, diagnosis, prognosis, stratification for therapy and response monitoring. Proteomics delineates gene products that carry out the majority of cellular functions, and thereby may not only yield insight into altered signaling pathways i...

journal_title：Expert review of molecular diagnostics

authors： Pham TV,Piersma SR,Oudgenoeg G,Jimenez CR

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Advances in the biology of non-small-cell lung cancer, especially adenocarcinoma, reveal multiple molecular subtypes driving oncogenesis. Accordingly, individualized targeted therapeutics are based on mutational diagnostics. AREAS COVERED:Advances in strategies and techniques for individualized treatment,...

journal_title：Expert review of molecular diagnostics

authors： Salgia R

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Although the majority of nasopharyngeal carcinoma (NPC) patients demonstrate favorable outcomes after radiotherapy and/or chemotherapy, about 8-10% of patients will develop recurrent disease, and genomic alterations (GAs) associated with the recurrence are unclear. METHODS:This study investigated the GAs in...

journal_title：Expert review of molecular diagnostics

authors： Cho WCS,Tse KP,Ngan RKC,Cheuk W,Ma VWS,Yang YT,Yip TTC,Tan KT,Chen SJ

更新日期：2020-11-01 00:00:00

abstract：:Although comprehensive molecular diagnostics and personalized medicine have sparked excitement among researchers and clinicians, they have yet to be fully incorporated into today's standard of care. This is despite the discovery of disease-related oncogenes, tumor-suppressor genes and protein biomarkers, as well as ot...

journal_title：Expert review of molecular diagnostics

authors： Zoon CK,Starker EQ,Wilson AM,Emmert-Buck MR,Libutti SK,Tangrea MA

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV) is a common opportunistic infection that contributes to poor outcomes in hematopoietic stem cell transplant (HSCT) recipients. Prevention of CMV end-organ disease in allogeneic HSCT recipients is commonly achieved by preemptive antiviral therapy of asymptomatic CMV reactivation that i...

journal_title：Expert review of molecular diagnostics

authors： Ramanan P,Razonable RR

更新日期：2017-07-01 00:00:00

abstract：:Background: We analyzed the correlation between heart-type fatty acid-binding protein (HFABP) and the development of acute kidney injury (AKI) in patients with sepsis and estimated the predictive capacity of HFABP for sepsis-associated acute kidney injury (SAKI). Methods: In this retrospective observational study, we ...

journal_title：Expert review of molecular diagnostics

authors： Jiang D,Shen M,Yuan X,Wang M,Li S,Jiang W,Zhou Z,Xi P,Wang T,Shen Y

更新日期：2019-08-01 00:00:00