Abstract:
:Malignant melanoma is one of the most aggressive cancers. Several new therapeutic strategies that focus on immuno- and/or targeted therapy have been developed, which have entered clinical trials or already been approved. This review provides an update on prognostic and predictive biomarkers in melanoma that may be used to improve the clinical management of patients. Prognostic markers include conventional histopathological characteristics, chromosomal aberrations, gene expression patterns and miRNA profiles. There is a trend towards multi-marker assays and whole-genome molecular screening methods to determine the prognosis of individual patients. Predictive biomarkers, including targeted components of signal transduction, developmental or transcriptional pathways, can be used to determine patient response towards a particular treatment or combination thereof. The rapid evolution of sequencing technologies and multi-marker screening will change the spectrum of patients who become candidates for therapeutic agents, and in addition create new ethical and regulatory challenges.
journal_name
Expert Rev Mol Diagnjournal_title
Expert review of molecular diagnosticsauthors
Foth M,Wouters J,de Chaumont C,Dynoodt P,Gallagher WMdoi
10.1586/14737159.2016.1126511subject
Has Abstractpub_date
2016-01-01 00:00:00pages
223-37issue
2eissn
1473-7159issn
1744-8352journal_volume
16pub_type
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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journal_title:Expert review of molecular diagnostics
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journal_title:Expert review of molecular diagnostics
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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