Abstract:
:To study distribution and patterns of nerve hypertrophy in chronic inflammatory demyelinating polyneuropathy (CIDP), magnetic resonance neurography with 3-dimensional reconstruction of short tau inversion recovery images was performed in 33 patients. This technique clearly showed longitudinal morphological changes from the cervical roots to the nerve trunks in the proximal arm. Nerve enlargement was detected in 88% of the patients. According to the clinical subtype of CIDP, typical CIDP patients showed symmetric and root-dominant hypertrophy, whereas Lewis-Sumner syndrome patients had multifocal fusiform hypertrophy in the nerve trunks. The patterns of nerve hypertrophy presumably reflect the different pathophysiology of each CIDP subtype.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Shibuya K,Sugiyama A,Ito S,Misawa S,Sekiguchi Y,Mitsuma S,Iwai Y,Watanabe K,Shimada H,Kawaguchi H,Suhara T,Yokota H,Matsumoto H,Kuwabara Sdoi
10.1002/ana.24314subject
Has Abstractpub_date
2015-02-01 00:00:00pages
333-7issue
2eissn
0364-5134issn
1531-8249journal_volume
77pub_type
杂志文章abstract::Benzodiazepines can regulate neoplastic growth and immune response through specific peripheral benzodiazepine receptors. We investigated the presence of peripheral and classic central benzodiazepine receptors as well as diazepam-binding inhibitor, an endogenous ligand of both types of receptors, in different human cer...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410260411
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:The prevalence of mitochondrial disease has proven difficult to establish, predominantly as a result of clinical and genetic heterogeneity. The phenotypic spectrum of mitochondrial disease has expanded significantly since the original reports that associated classic clinical syndromes with mitochondrial DNA (...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.24362
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Amyotrophic lateral sclerosis/parkinsonism-dementia complex has been described in Guam, Western Papua, and the Kii Peninsula of Japan. The etiology and pathogenesis of this complex neurodegenerative disease remains enigmatic. METHODS:In this study, we have used targeted genomic sequencing to evaluate the con...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.24346
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:Axonal degeneration is a main contributor to disability in progressive neurodegenerative diseases in which oxidative stress is often identified as a pathogenic factor. We aim to demonstrate that antioxidants are able to improve axonal degeneration and locomotor deficits in a mouse model of X-adrenoleukodystro...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.22363
更新日期:2011-07-01 00:00:00
abstract::White matter degeneration is one of the pathological conditions of dentatorubral-pallidoluysian atrophy. Autopsy brains exhibited a reduced number of glial cells in the lesions and an involvement of oligodendrocytes in nuclear inclusion formation, which previously has been recognized only as a pathological hallmark in...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.10352
更新日期:2002-11-01 00:00:00
abstract::Several mutations in the amyloid precursor protein (APP) gene have been found to associate with pathologic deposition of the beta-amyloid peptide (Abeta) in neuritic plaques or in the walls of cerebral vessels. We report a mutation at a novel site in APP in a three-generation Iowa family with autosomal dominant dement...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.1009
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:Patients with temporal lobe epilepsy often display cognitive comorbidity with recurrent seizures. However, the cellular mechanisms underlying the impairment of neuronal information processing remain poorly understood in temporal lobe epilepsy. Within the hippocampal formation neuronal networks undergo major r...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.24348
更新日期:2015-04-01 00:00:00
abstract::Three of six rabbits immunized with purified GD1b developed ataxic sensory neuropathy. They laid on the floor with their limbs splayed out, and their movements were awkward; but muscle power, tonus, and superficial sensation appeared to be intact. Sciatic nerve motor conduction studies were normal. Axonal degeneration...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410390404
更新日期:1996-04-01 00:00:00
abstract::Unexpected sudden death is a common event in otherwise healthy epileptics, though its etiology has remained unclear. Many authors have suggested cardiac arrhythmias as the cause, and limited data in humans and animal studies have supported this. However, autopsy series in humans have shown pulmonary edema, a phenomeno...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410370416
更新日期:1995-04-01 00:00:00
abstract::We have previously shown bilateral activation of motor pathways and the recruitment of additional motor areas in studies of groups of patients with recovery from motor stroke. We have now developed a new positron emission tomographic technique to measure the changes in regional cerebral blood flow elicited during a mo...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410330208
更新日期:1993-02-01 00:00:00
abstract::In adult brain, during insulin-induced hypoglycemia, striatal extracellular fluid concentrations of the excitatory amino acids glutamate and aspartate rise markedly (fourfold to tenfold). In this study, we used in vivo microdialysis to determine if insulin-induced hypoglycemia altered striatal amino acid efflux in sim...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410280408
更新日期:1990-10-01 00:00:00
abstract::The highly encephalitogenic guinea pig peptide 68-88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmol of the peptide in complete Fre...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410070409
更新日期:1980-04-01 00:00:00
abstract:OBJECTIVE:Chorioamnionitis is associated with increased risk for cerebral palsy (CP) in term infants. A functional polymorphism in the interleukin-6 (IL-6) gene has been implicated in newborn brain injury. We studied whether the IL-6 -174 G/C polymorphism confers increased risk for CP in term infants. METHODS:This pop...
journal_title:Annals of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ana.21766
更新日期:2009-11-01 00:00:00
abstract::Fourteen children with brain tumors received endocrine evaluations at least one year following completion of cranial irradiation. Treatment consisted of operation (13 patients), craniospinal irradiation (6), whole brain irradiation (5), posterior fossa irradiation (3), and chemotherapy (10). Endocrine evaluation inclu...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410140506
更新日期:1983-11-01 00:00:00
abstract::Prevalence and titer of total, free, and bound cerebrospinal fluid anti-myelin basic protein (MBP) antibodies as well as free/bound ratios were determined in four groups of patients with multiple sclerosis (MS) and three groups of controls. All patients with clinically active MS have elevated levels of total anti-MBP,...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410200105
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS:We performed a systematic review and individual patient data meta-analysis of cohort studie...
journal_title:Annals of neurology
pub_type: 杂志文章,meta分析
doi:10.1002/ana.25342
更新日期:2018-11-01 00:00:00
abstract::Free and bound levels of anti-myelin basic protein (anti-MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of 20 patients with acute idiopathic optic neuritis, 133 patients with multiple sclerosis (MS) divided into three clinical subgroups, and 76 normal control subjects. Patients with idiop...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410230314
更新日期:1988-03-01 00:00:00
abstract::Intraneural perineuriomas are benign peripheral nerve sheath tumors that cause progressive debilitating focal extremity weakness. The etiology of perineuriomas is largely unknown. We utilized whole exome sequencing, copy number algorithm evaluation, and high-resolution whole genome microarray to investigate for a gene...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.24854
更新日期:2017-02-01 00:00:00
abstract::Neurosurgical procedures such as the dorsal root entry zone operation, ganglionectomy, and spinal-cord stimulation have been offered to patients with intractable post-herpetic neuralgia (PHN). Poor efficacy or high morbidity have limited the overall usefulness of these procedures. We recently conducted a preliminary o...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410350716
更新日期:1994-01-01 00:00:00
abstract::To determine whether the association of the very low density lipoprotein receptor (VLDL-R) gene with Alzheimer's disease (AD), which has recently been identified in Japanese AD patients, is commonly observed in AD patients of other ethnic backgrounds, we have investigated the allele frequency of the polymorphic CGG re...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410400220
更新日期:1996-08-01 00:00:00
abstract::To investigate the potential role of drug therapy in preventing or exacerbating seizure-related brain injury in the prepubescent brain, we administered kainic acid to rats at postnatal day 35. Therapy with daily phenobarbital was started directly before or 1 day after kainic acid was administered, and was continued th...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410360314
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Recent studies have identified a subset of outgrowth cell population with endothelial phenotype in long-term cultures of peripheral blood mononuclear cells. The concept that peripheral blood-derived cells participate in neuronal regeneration remains highly controversial, and no specific cell type has been ide...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.21303
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Epilepsy is a common neurological disorder characterized by recurrent seizures often unresponsive to pharmacological treatment. Brain inflammation is considered a crucial etiopathogenetic mechanism of epilepsy that could be targeted to control seizures. Specific inflammatory mediators overexpressed in human e...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.23567
更新日期:2012-07-01 00:00:00
abstract::The ability to distinguish adaptive cortical reorganization may help to target future therapeutic strategies after neurological insult. We investigated cortical plasticity by prospectively applying visual functional magnetic resonance imaging (fMRI) and optic nerve MRI to 20 patients with acute optic neuritis at basel...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20448
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more strongly than white matter (WM) atrophy with disability. The corresponding relationships in the spinal cord (SC) are unknown due to technical limitations in assessing SC GM atrophy. Using phase-sensitive inversion recovery (PSIR) ma...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.24241
更新日期:2014-10-01 00:00:00
abstract::Unilateral lesions of the occipital visual areas performed on postnatal day 5 (P5) in the ferret are not compensated by the appearance, in the lesioned hemisphere, of visual responses at ectopic locations. Instead, when parts of the visual areas are spared, they show abnormal retinotopic organizations; furthermore, ca...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.10591
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Neuronal channelopathies cause brain disorders, including epilepsy, migraine, and ataxia. Despite the development of mouse models, pathophysiological mechanisms for these disorders remain uncertain. One particularly devastating channelopathy is Dravet syndrome (DS), a severe childhood epilepsy typically cause...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.23897
更新日期:2013-07-01 00:00:00
abstract::Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410420115
更新日期:1997-07-01 00:00:00
abstract::Fifty children with marked neurological abnormality manifested by moderate or severe motor disability and severe mental retardation were compared with a large control population with respect to prospectively ascertained perinatal characteristics. None of 60 prenatal factors distinguished the affected group from contro...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410020505
更新日期:1977-11-01 00:00:00
abstract::We describe a family of 9 affected individuals in three generations with nocturnal oro-facio-brachial partial seizures, secondarily generalized partial seizures, and centro-temporal epileptiform discharges, associated with oral and speech dyspraxia and cognitive impairment. The speech disorder was prominent, but diffe...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410380412
更新日期:1995-10-01 00:00:00