Abstract:
:Evolve and resequence (E&R) is a new approach to investigate the genomic responses to selection during experimental evolution. By using whole genome sequencing of pools of individuals (Pool-Seq), this method can identify selected variants in controlled and replicable experimental settings. Reviewing the current state of the field, we show that E&R can be powerful enough to identify causative genes and possibly even single-nucleotide polymorphisms. We also discuss how the experimental design and the complexity of the trait could result in a large number of false positive candidates. We suggest experimental and analytical strategies to maximize the power of E&R to uncover the genotype-phenotype link and serve as an important research tool for a broad range of evolutionary questions.
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Schlötterer C,Kofler R,Versace E,Tobler R,Franssen SUdoi
10.1038/hdy.2014.86subject
Has Abstractpub_date
2015-05-01 00:00:00pages
431-40issue
5eissn
0018-067Xissn
1365-2540pii
hdy201486journal_volume
114pub_type
杂志文章,评审相关文献
HEREDITY文献大全abstract::Assessing in wild populations how fitness is impacted by inbreeding and genetic drift is a major goal for conservation biology. An approach to measure the detrimental effects of inbreeding on fitness is to estimate correlations between molecular variation and phenotypic performances within and among populations. Our s...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2012.110
更新日期:2013-04-01 00:00:00
abstract::The genetic differentiation of populations is usually studied by using the equilibrium theory of Wright's infinite island model. In practice, however, populations are not always in equilibrium, and the number of subpopulations is often very small. To get some insight into the dynamics of genetic differentiation of the...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1986.109
更新日期:1986-10-01 00:00:00
abstract::Gene flow via pollen movement affects genetic variation in plant populations and is an important consideration in plant domestication. Fontainea picrosperma is a subcanopy rainforest tree that is of commercial interest because it is the source of tigilanol tiglate, a natural product used for the treatment of solid tum...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0231-1
更新日期:2019-10-01 00:00:00
abstract::Matrilineal phylogenetic divergence among Atlantic salmon stocks of the Bay of Fundy in south eastern Canada is investigated. Sequence variation in two regions of the mitochondrial ND1 gene, encompassing 710 base pairs, is described for 168 salmon from 11 rivers. Mean overall haplotype and nucleotide diversity (h and ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800166
更新日期:2002-12-01 00:00:00
abstract::Complete D-loop sequences of 20 Mus from three localities in Turkey and seven in Iran were characterized. These countries are thought to be close to the place of origin of the subspecies Mus musculus domesticus. Five new M. m. domesticus haplotypes were added to the nine already known for the region. Four of these 14 ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.2000.00694.x
更新日期:2000-04-01 00:00:00
abstract::Recent molecular genetic analyses of Drosophila melanogaster and mouse central nervous system (CNS) development revealed strikingly similar genetic patterning mechanisms in the formation of the insect and vertebrate brain. Thus, in both insects and vertebrates, the correct regionalization and neuronal identity of the ...
journal_title:Heredity
pub_type: 杂志文章,评审
doi:10.1038/sj.hdy.6800664
更新日期:2005-05-01 00:00:00
abstract::Fisher's model for the evolution of dominance indicates that the accumulation of dominance modifiers will be accelerated by (1) an increased frequency of the mutant heterozygote, (2) increased selection for the phenotype of the normal homozygote. The model has been criticised by Haldane on the grounds that point (1) i...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1977.13
更新日期:1977-02-01 00:00:00
abstract::Invasive hybrids and their spread dynamics pose unique opportunities to study evolutionary processes. Invasive hybrids of native Spartina foliosa and introduced S. alterniflora have expanded throughout San Francisco Bay intertidal habitats within the past 35 years by deliberate plantation and seeds floating on the tid...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2010.63
更新日期:2011-04-01 00:00:00
abstract::Genetic architecture and phenotypic plasticity are important considerations when studying trait variation within and among populations. Since environmental change can induce shifts in the genetic architecture and plasticity of traits, it is important to consider both genetic and environmental sources of phenotypic var...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0346-4
更新日期:2021-01-01 00:00:00
abstract::Almost a quarter of a century ago, the banding patterns of human and other higher primate chromosomes were compared, creating a barrage of speculation. Consequently, a number of approaches have been used to understand human descent. Chromosome modifications are believed to be important in the origin of species, and pe...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.1998.00362.x
更新日期:1998-07-01 00:00:00
abstract::Apomixis is a mode of asexual reproduction through seed. Progeny produced by apomixis are clonal replicas of a mother plant. The essential feature of apomixis is that embryo sacs and embryos are produced in ovules without meiotic reduction or egg cell fertilisation. Thus, apomixis fixes successful gene combinations an...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800808
更新日期:2006-04-01 00:00:00
abstract::Echinoderms represent a researchable subset of a dynamic larval evolutionary cosmos. Evolution of echinoderm larvae has taken place over widely varying time scales from the origins of larvae of living classes in the early Palaeozoic, approximately 500 million years ago, to recent, rapid and large-scale changes that ha...
journal_title:Heredity
pub_type: 杂志文章,评审
doi:10.1038/sj.hdy.6800866
更新日期:2006-09-01 00:00:00
abstract::We report the first sex-linked loci in Oncorhynchus mykiss (rainbow trout). Previous cytological and breeding experiments have demonstrated an XX/XY sex determining system in this and other salmonid species. Joint segregation data from fathers indicated an average of 8.1 per cent recombination between HEX-2 and the se...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1994.67
更新日期:1994-05-01 00:00:00
abstract::Genetic segregation was studied in more than 1900 seedlings of an F2 between the maize (Zea mays L.) inbred lines T232 and CM37. Significant segregation distortion was observed at 11 of 17 segregating allozyme loci and at a single morphological marker locus distributed on 7 of the 10 chromosomes in the genome. Deviati...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1987.44
更新日期:1987-04-01 00:00:00
abstract::A penalized maximum likelihood method has been proposed as an important approach to the detection of epistatic quantitative trait loci (QTL). However, this approach is not optimal in two special situations: (1) closely linked QTL with effects in opposite directions and (2) small-effect QTL, because the method produces...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2011.86
更新日期:2012-04-01 00:00:00
abstract::Genomic selection has become a reality in plant breeding programs with the reduction in genotyping costs. Especially in maize breeding programs, it emerges as a promising tool for predicting hybrid performance. The dynamics of a commercial breeding program involve the evaluation of several traits simultaneously in a l...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0321-0
更新日期:2020-08-01 00:00:00
abstract::Nucleotide diversity was assessed within nine candidate genes (CGs) (in total 4.6 kb) for the time of bud burst in nine sessile oak (Quercus petraea) populations distributed in central and northern Europe. The sampled populations were selected on the basis of their contrasting times of bud burst observed in common gar...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2009.134
更新日期:2010-05-01 00:00:00
abstract::Nothofagus cunninghamii is a long-lived, wind-pollinated tree species that dominates the cool temperate rainforests of southeastern Australia. The species' distribution is more or less continuous in western Tasmania but is fragmented elsewhere. However, it is unknown whether this fragmentation has affected the species...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2015.77
更新日期:2016-01-01 00:00:00
abstract::A high-resolution transcript linkage map of barley was created using a single doubled haploid (DH) mapping population, only 3'-end expressed sequence tags (ESTs) and only PCR-based assays. Cultivar 'Haruna Nijo' and an ancestral wild-form accession 'H602' were used as EST donors and crossing parents of the mapping pop...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2009.57
更新日期:2009-08-01 00:00:00
abstract::Asexual reproduction via thelytokous parthenogenesis is widespread in the Hymenoptera, but its genetic underpinnings have been described only twice. In the wasp Lysiphlebus fabarum and the Cape honey bee Apis mellifera capensis the origin of thelytoky have each been traced to a single recessive locus. In the Cape hone...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2014.127
更新日期:2015-06-01 00:00:00
abstract::How life-history strategies influence the evolution of populations is not well understood. Most existing models stem from the Wright-Fisher model which considers discrete generations and a fixed population size, thus not taking into account any potential consequences of overlapping generations and demographic stochast...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0118-6
更新日期:2018-10-01 00:00:00
abstract::For morphological traits that are negatively correlated, the genetic correlation (rg) between them might strongly influence patterns of morphological divergence and shape. Here, the pattern of divergence between two sibling species of cactophilic Drosophila, D. buzzatii and D. koepferae, is examined for two traits tha...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.2000.00735.x
更新日期:2000-08-01 00:00:00
abstract::Porcellionides pruinosus is a cosmopolitan woodlouse. It is known to exhibit patterns of geographical variation between populations, and has been suspected to consist of several very closely related species. This species was found to carry Wolbachia endosymbionts, alpha-proteobacteria which are known to modify the rep...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.2001.00920.x
更新日期:2001-10-01 00:00:00
abstract::The Africanization of the honeybee (Apis mellifera) in South America is one of the most spectacular examples of biological invasions. In this study, we analyzed the Africanization process in Central Mexico along an altitudinal transect from 72 to 2800 m, using both mitochondrial and nuclear DNA markers. The mitochondr...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800988
更新日期:2007-08-01 00:00:00
abstract::As important as the events that influence selection for specific chromosome types in the derivation of novel karyotypes, are the events that initiate the changes in chromosome number and structure between species, and likewise polymorphisms, variants and disease states within species. Although once thought of as trans...
journal_title:Heredity
pub_type: 杂志文章,评审
doi:10.1038/hdy.2011.104
更新日期:2012-01-01 00:00:00
abstract::Estimating kinship is fundamental for studies of evolution, conservation, and breeding. Genotyping-by-sequencing (GBS) and other restriction based genotyping methods have become widely applied in these applications in non-model organisms. However, sequencing errors, depth, and reproducibility between library preps cou...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0302-3
更新日期:2020-05-01 00:00:00
abstract::The genetic control of self-incompatibility (SI) was studied in the Mediterranean short-lived perennial species Anagallis monelli (Primulaceae: Myrsinaceae). Arrays of siblings, including families derived from reciprocal crosses, were cross-pollinated in full diallels, and compatibility groups were assesssed from a ce...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.2001.00951.x
更新日期:2001-11-01 00:00:00
abstract::Genetic effects of habitat fragmentation may be undetectable because they are generally a recent event in evolutionary time or because of confounding effects such as historical bottlenecks and historical changes in species' distribution. To assess the effects of demographic history on the genetic diversity and populat...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2013.23
更新日期:2013-08-01 00:00:00
abstract::Seed dormancy is a key adaptive trait under polygenic control in many plants. We introduced the chromosomal regions containing the dormancy QTLs qSD1, qSD7-1, and qSD12 from an accession of weedy rice into a nondormant genetic background to examine component genetic effects and their interactions with time of afterrip...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800757
更新日期:2006-01-01 00:00:00
abstract::F-statistics were employed to analyse quantitative and allozyme variation among 19 native populations of maritime pine (Pinus pinaster Ait.). Fourteen polymorphic allozyme loci were used to provide an empirical basis for constructing a null hypothesis to test natural selection as a determinant of quantitative evolutio...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800114
更新日期:2002-09-01 00:00:00