Abstract：
:Fisher's model for the evolution of dominance indicates that the accumulation of dominance modifiers will be accelerated by (1) an increased frequency of the mutant heterozygote, (2) increased selection for the phenotype of the normal homozygote. The model has been criticised by Haldane on the grounds that point (1) is not fulfilled, that is dominance appears to be more common in populations with a low frequency of mutant heterozygotes (populations of inbreeders). In support of Fisher's model it is argued that intense selection for the wild type phenotype is more common in inbreeders than outbreeders. This situation should promote the accumulation of dominance modifiers (point (2) above).
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Manning JTdoi
10.1038/hdy.1977.13subject
Has Abstractpub_date
1977-02-01 00:00:00pages
117-9issue
1eissn
0018-067Xissn
1365-2540journal_volume
38pub_type
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