A review of options for treating sialorrhea in amyotrophic lateral sclerosis.

Abstract:

:Sialorrhea or drooling represents quite a common problem in patients with amyotrophic lateral sclerosis (ALS). In this review, we describe the possible treatments for this issue. Current medical management is not always effective: anticholinergic drugs (atropine, glycopyrrolate, amitriptyline, hyoscyamine, and transdermal scopolamine) are often used, but there is very little evidence of their effectiveness in patients with ALS. More invasive treatments, such as botulinum toxin injections and/or radiation therapy in the salivary glands, can be considered when anticholinergic drugs are not effective. In this review, we also explore the possible surgical options for treatment of sialorrhea. Although no specific studies have been conducted on patients with ALS, surgical therapies might represent a valid option for treatment of sialorrhea since there is no tachyphylaxis or need for repeated therapeutic sessions.

journal_name

Respir Care

journal_title

Respiratory care

authors

Banfi P,Ticozzi N,Lax A,Guidugli GA,Nicolini A,Silani V

doi

10.4187/respcare.02856

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

446-54

issue

3

eissn

0020-1324

issn

1943-3654

pii

respcare.02856

journal_volume

60

pub_type

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