Abstract:
:Sialorrhea or drooling represents quite a common problem in patients with amyotrophic lateral sclerosis (ALS). In this review, we describe the possible treatments for this issue. Current medical management is not always effective: anticholinergic drugs (atropine, glycopyrrolate, amitriptyline, hyoscyamine, and transdermal scopolamine) are often used, but there is very little evidence of their effectiveness in patients with ALS. More invasive treatments, such as botulinum toxin injections and/or radiation therapy in the salivary glands, can be considered when anticholinergic drugs are not effective. In this review, we also explore the possible surgical options for treatment of sialorrhea. Although no specific studies have been conducted on patients with ALS, surgical therapies might represent a valid option for treatment of sialorrhea since there is no tachyphylaxis or need for repeated therapeutic sessions.
journal_name
Respir Carejournal_title
Respiratory careauthors
Banfi P,Ticozzi N,Lax A,Guidugli GA,Nicolini A,Silani Vdoi
10.4187/respcare.02856subject
Has Abstractpub_date
2015-03-01 00:00:00pages
446-54issue
3eissn
0020-1324issn
1943-3654pii
respcare.02856journal_volume
60pub_type
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