Abstract：
:Although some clinicians still believe that cystic fibrosis (CF) lung disease is largely due to hypersecretion of very viscous mucus, it has never been demonstrated that there is mucus hypersecretion in CF and it is clear that there is almost no intact mucin (the principal polymeric component of normal mucus) in CF sputum. CF sputum has lower viscosity when compared to asthma or bronchitis sputa, but is highly tenacious and biochemically most closely resembles pus. Tenacity and lower viscosity lead to decreased cough clearance of infected phlegm, which is thought to induce a persistent inflammatory state in the airway, leading to bronchiectasis. There are many medications and devices either in use or under development that are meant to improve airway hygiene in CF by assisting with sputum expectoration. This paper discusses the scientific basis and potential mechanism of action for many of these interventions and briefly reviews the clinical evidence of their safety and effectiveness.
journal_name
Respir Carejournal_title
Respiratory careauthors
Rubin BKdoi
10.4187/002013209790983269subject
Has Abstractpub_date
2009-06-01 00:00:00pages
726-32; discussion 732issue
6eissn
0020-1324issn
1943-3654journal_volume
54pub_type
杂志文章,评审相关文献
Respiratory Care文献大全abstract：BACKGROUND:Gas exchange measurements for carbon dioxide elimination (V̇CO2 ) and oxygen consumption (V̇O2 ) have been used to derive resting energy expenditure and guide energy prescription. Volumetric capnography is used in intensive care units and provides V̇CO2 measurements that could be used for titrating respirato...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.04282
更新日期：2016-03-01 00:00:00
abstract：:Exposure to chemical agents, both deliberate and accidental, over the past 100 years has resulted in the deaths of thousands and a significant number of casualties requiring hospitalization. The respiratory system is an important portal of entry into the human body for many of these agents, and pulmonary symptoms are ...
journal_title：Respiratory care
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:The estimation of pleural pressure with esophageal manometry has been used for decades, and it has been a fertile area of physiology research in healthy subject as well as during mechanical ventilation in patients with lung injury. However, its scarce adoption in clinical practice takes its roots from the (false) idea...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：10.4187/respcare.07425
更新日期：2020-06-01 00:00:00
abstract：:Computer-age technology is changing the face of respiratory therapy as it is that of nearly every other technical field. In some hospital respiratory therapy departments computers are presently being used for a wide range of functions such as blood gas result reporting, billing, budgeting, purchasing, hemodynamic calc...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:CPAP is a spontaneous mode of ventilation that maintains a constant airway pressure during the inspiratory and expiratory phases. This therapeutic modality is used across the continuum of care from pre-hospital treatment to intensive and acute care units to the home care environment to treat a host of acute and chroni...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：10.4187/respcare.06625
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Although radio frequency (RF) systems have proliferated and are designed to simplify care delivery in many clinical settings, little information is available on the impact of such RF systems on the delivery of patient care. Having used a hand-held-device-based management information system in our Respiratory...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：UNLABELLED:Because of the temperature extremes encountered during emergency resuscitation and transport in the field, we sought to evaluate the performance and safety of 10 adult resuscitators (5 permanent units: Hope 4, Laerdal, Lifesaver, Mark 3, and PMR; and 5 disposable units: BagEasy, Code Blue, CPR Bag, DMR, and ...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:Exercise testing is part of the regular assessment of patients with cystic fibrosis (CF). We aimed to evaluate (1) the convergent validity of the 1-min sit-to-stand (STS) test in CF by investigating its relationships with peak oxygen uptake (peak V̇O2 ), quadriceps strength, and quality of life and (2) to co...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.04821
更新日期：2016-12-01 00:00:00
abstract：:Emerging antibiotic resistance has created a major public health dilemma, compounded by a dearth of new antibiotic options. Multidrug-resistant Gram-negative organisms have received less attention than Gram-positive threats, such as methicillin-resistant Staphylococcus aureus, but are just as menacing. Pathogens such ...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Nebulizers are a popular means of delivering aerosolized medication, primarily albuterol, to the bronchial airways of patients, and there has been extensive research done on numerous nebulizers used with nebulizer T-pieces and corrugated tubing. Very little research has been performed on other types of nebul...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to develop an efficient, low-cost, home-based pulmonary rehabilitation program and to evaluate the impact of the program on exercise as measured by the 6-min walk test (6MWT) and treadmill endurance test. METHODS:Twenty-nine subjects with COPD (FEV1 = 62.4 ± 10.7% of predicted, 62....
journal_title：Respiratory care
pub_type： 杂志文章,随机对照试验
doi：10.4187/respcare.02994
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Volume-targeted ventilation is increasingly used in low birthweight infants because of the potential for reducing volutrauma and avoiding hypocapnea. However, it is not known what level of air leak is acceptable during neonatal volume-targeted ventilation when leak compensation is activated concurrently. ME...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.05012
更新日期：2017-01-01 00:00:00
abstract：:A previously healthy 23-year-old man with nonproductive cough and sore throat presented to the hospital a few hours after chlorine gas exposure at a fitness center swimming pool. Initial physical examination and chest radiograph were normal. Thirty-six hours later he developed worsening dyspnea and cough, with develop...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Endotracheal intubation can lead to iatrogenic trauma to the upper airways. Superficial mucosal tears in the mouth, pharynx, or larynx are common and can cause secondary infection and acute respiratory distress due to massive air leak. We report a patient who sustained a severe 5-cm tracheal laceration and subcutaneou...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.00891
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:A clinical classification system has been developed to define the severity and predict the prognosis of subjects with non-cystic fibrosis (CF) bronchiectasis. We aimed to identify laboratory parameters that are correlated with the bronchiectasis severity index (BSI) and FACED score. METHODS:The medical reco...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.05276
更新日期：2017-08-01 00:00:00
abstract：:End-stage liver disease and its complications are a leading cause of death among adults in the United States, and thousands of patients await liver transplantation. The liver plays a central role in health and homeostasis and thus the diseased liver leads to many deleterious effects on multiple organ systems, includin...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Decreasing electrostatic charge on valved holding chambers increases the amount of drug delivered. However, there are no data demonstrating that this increases bronchodilatation. OBJECTIVE:To investigate the influence of reducing electrostatic charge on the bronchodilator response to albuterol inhaler duri...
journal_title：Respiratory care
pub_type： 杂志文章,随机对照试验
doi：10.4187/respcare.01572
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Chest x-ray (CXR) is widely used for diagnosing and screening pulmonary tuberculosis (PTB), yet its validity is debatable and its costs are relatively high. This study aimed to determine the validity of CXR screening in detecting radiological findings compatible with active PTB or with old healed tuberculos...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.01475
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:The human respiratory airway undergoes dramatic growth during infancy and childhood, which induces substantial variability in air flow pattern and particle deposition. However, deposition studies have typically focused on adult subjects, the results of which cannot be readily extrapolated to children. We dev...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02568
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Studies on the submaximal aerobic capacity of exclusive narghile smokers (ENS) seem necessary in view of effective prevention of cardiorespiratory diseases. The goal of the study was to assess, by 6-min walk test (6MWT) data, the submaximal aerobic capacity of ENS, to identify factors influencing their 6-min...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.03058
更新日期：2014-11-01 00:00:00
abstract：:Gorham syndrome is a rare disease that presents as progressive osteolysis, and may affect any part of the skeleton. The pathologic process involves the replacement of normal bone by aggressively expanding but non-neoplastic vascular tissue, resulting in massive osteolysis of the adjacent bone. If the spine and ribs ar...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02355
更新日期：2013-11-01 00:00:00
abstract：:Ventilator circuits should not be changed routinely for infection control purposes. The maximum duration of time that circuits can be used safely is unknown. Evidence is lacking related to ventilator-associated pneumonia (VAP) and issues of heated versus unheated circuits, type of heated humidifier, method for filling...
journal_title：Respiratory care
pub_type： 指南,杂志文章,实务指引
doi：
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Emphysema and fibrosis, typically the idiopathic pulmonary fibrosis (IPF) form of usual interstitial pneumonia (UIP), can co-exist as combined pulmonary fibrosis emphysema (CPFE). It is unknown whether there is a pathobiologic basis for CPFE beyond the coexistence of fibrosis and emphysema. The aim of this s...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.03389
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Dynamic airway resistance from obstructive disease causes a concavity in the mid-expiratory portion of the spirometric flow-volume loop. We developed a simple model to measure the exponential decay in air flow during forced exhalation to quantify the extent of dynamic airway obstruction and facilitate the de...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.04850
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION:Common modalities of clinical exercise testing for outcome measurement after pulmonary rehabilitation (PR) include walk tests, progressive cycle ergometry, and cycle endurance testing. We hypothesized that patients' responses to PR, as measured by those 3 tests, are differentially correlated, and we design...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:A 20-year-old man was admitted in the neurology ICU after the drainage of a large frontal hematoma related to the spontaneous bleeding of a recently diagnosed cavernoma. On admission the Glasgow coma score was 4/15, with evidence of sub-falcorial herniation and elevated intracranial pressure. On the 4th postoperative...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.01322
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:The contribution of the central respiratory drive in the hypercapnic respiratory failure of neuromuscular diseases (NMD) is controversial. OBJECTIVE:To compare the CO2 response and the duration of weaning of mechanical ventilation between a group of NMD patients and a group of quadriplegic patients due to I...
journal_title：Respiratory care
pub_type： 杂志文章,多中心研究
doi：10.4187/respcare.01873
更新日期：2013-03-01 00:00:00
abstract：:Inhaled aerosol drugs commonly used by patients with chronic obstructive pulmonary disease include short-acting and long-acting bronchodilators, as well as corticosteroids. These agents are available in a variety of inhaler devices, which include metered-dose inhalers (MDI), breath-actuated MDIs, nebulizers, and, curr...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Continuous high-frequency oscillation (CHFO) is a therapeutic mode for the mobilization of secretions. The Metaneb CHFO device also incorporates aerosol administration using an integrated jet nebulizer. However, the effectiveness of aerosol delivery and influential factors remain largely unreported. METHODS...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.07050
更新日期：2020-02-01 00:00:00
abstract：:Pressure support ventilation (PSV) is a commonly used mode. It is patient-triggered, pressure-limited, and (normally) flow-cycled. Triggering difficulty occurring during PSV is usually due to intrinsic positive end-expiratory pressure. The airway pressure generated at the initiation of inhalation is determined by the ...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2005-02-01 00:00:00
