Abstract:
PURPOSE:To examine the feasibility of simultaneous acquisition of F-fluoroethylcholine (F-choline) PET and functional MRI (standardized uptake value [SUV]max/mean and apparent diffusion coefficient [ADC]mean), using a hybrid PET/MRI scanner, for diagnosis and response assessment in a cohort of children with astrocytic brain tumors. METHODS:F-choline PET/MRI scans were performed in 12 patients with proven astrocytic tumors.Eight patients simultaneously underwent F-choline PET/MR follow-up scans after treatment. Uptake in the lesion above the normal brain activity was considered indicative of a positive scan. Maximum and mean SUVs (SUVmax and SUVmean) and mean ADC (ADCmean) of the whole tumor region of interest were assessed. Lesion size and contrast enhancement were recorded. For all tumors, the association between ADCmean and SUVmean/SUVmax values were assessed using the Spearman correlation coefficient. RESULTS:At baseline, the areas of F-choline uptake matched areas of contrast enhancement and restricted diffusion. There was a negative correlation trend between SUVmax and ADCmean and a positive correlation trend between SUVmax and tumor size. There was concordance between reduction in tumor size and reductions in SUVmax and SUVmean in 4 children, in three of whom ADCmean values were increased. In 2 patients, tumor size remained stable whereas SUVmax and SUVmean values were increased with reduction in the ADCmean values. Additionally, in 2 children, cross-sectional MRI showed an increase both in tumor size and SUVmax but a reduction in ADC values. CONCLUSIONS:Simultaneous F-choline PET/MRI is a promising and reliable imaging tool for children with astrocytic tumors, as it permits monitoring of morphological and metabolic response and changes during therapy.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Fraioli F,Shankar A,Hargrave D,Hyare H,Gaze MN,Groves AM,Alongi P,Stoneham S,Michopoulou S,Syed R,Bomanji JBdoi
10.1097/RLU.0000000000000556subject
Has Abstractpub_date
2015-01-01 00:00:00pages
e40-5issue
1eissn
0363-9762issn
1536-0229journal_volume
40pub_type
杂志文章abstract::Cortical alterations of brain metabolism, as seen in PET, obviously depend on the nature of the damage (either mechanical, toxic, anoxic, or other). However, some subcortical abnormalities seem to occur rather frequently regardless of the extension, position and cause of the damage. In particular, relative cerebellar ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3180537621
更新日期:2007-06-01 00:00:00
abstract::During a Tc-99m DTPA study, activity simultaneously appeared in the kidneys and in a right lateral band. This was due to an inflammatory tract and not to urinary drainage. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198601000-00020
更新日期:1986-01-01 00:00:00
abstract::Ventriculoperitoneal shunt malfunction is common in patients after shunt surgery. Imaging is done to reveal the underlying cause and confirm the diagnosis. Shunt infection is one of the common causes of shunt malfunction. FDG PET CT is an accepted infection imaging tool and can be used to diagnose shunt infection accu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002756
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas. MATERIALS AND METHODS:F-18 DOPA PET examinations were performed in 9 patients with 7 pheochromocytomas and 4 head and neck paragangliomas using a de...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318238f550
更新日期:2012-02-01 00:00:00
abstract::Hepatobiliary scintigraphy has been recognized as a useful diagnostic tool in detecting the presence and site of bile leaks. The authors report a case of bile ascites secondary to a postsurgical biliary leak, the scintigraphic findings in bile ascites, and the potential use of paracentesis, in combination with hepatob...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198506000-00004
更新日期:1985-06-01 00:00:00
abstract::A 72-year-old man with a history of prostate adenocarcinoma initially managed by radical prostatectomy and salvage radiation therapy underwent resection of a left vas deferens recurrence identified on PSMA PET. Despite an initial response, PSA failed to fall below 3.5 ng/L, prompting re-evaluation with PSMA PET/CT: a ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003136
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:The present study aimed to determine the predictive value of the heart-liver uptake ratio (H/L ratio) of rectally administered (201)Tl scintigraphy for hepatic decompensation, which was conducted in 107 patients with cirrhosis. METHODS:We retrospectively assessed the predictive value of a noninvasive parameter...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827087e3
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Primary hyperparathyroidism is a disease of uncertain etiology that results from hypersecretion of parathyroid hormone (PTH) by the parathyroid gland. In most institutions, the preferred imaging protocol utilizes a dual-phase technique with Tc-99m sestamibi which is reported to be more sensitive than earlier pr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199804000-00003
更新日期:1998-04-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the redifferentiative and antiproliferative effects of rosiglitazone in patients with progressive differentiated thyroid cancer (DTC) without or with negligible overall radioiodine uptake. MATERIALS AND METHODS:A total of 9 patients with progressive DTC with either no or only ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182443ca6
更新日期:2012-03-01 00:00:00
abstract::Brucellosis is an endemic disease in the Middle East. Its incidence in Kuwait has increased during the last 5 years. Bone and joint involvement causes major symptoms and disabilities. Radionuclide bone scans are more sensitive than radiographs in detecting these lesions. The aim of this study is to describe the abnorm...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198802000-00008
更新日期:1988-02-01 00:00:00
abstract::A 37-year-old patient with severe hypokalemia (approximately 1.7 mEq/L) and muscular weakness had a very high serum renin level. No renin-producing tumor was found and she was diagnosed with Bartter Syndrome The parathyroid hormone level was high due to concomitant renal calcium loss. Tc-99m-DTPA captopril scintigraph...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000156381.00197.da
更新日期:2005-04-01 00:00:00
abstract::A 66-year-old white man with amiodarone pneumonitis is presented. The diagnosis was made with the aid of Ga-67 imaging, which is a sensitive method of detecting amiodarone pulmonary toxicity in patients with symptomatic pulmonary infiltrates on chest radiographs. Ga-67 imaging is especially useful in distinguishing am...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198811000-00012
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:Renal biopsy is crucial for management of lupus nephritis. However, it is invasive and can cause bleeding and infection. In our previous study, we developed a semiquantitative method for gallium renal imaging and demonstrated a good correlation between the left kidney-to-spine ratio (K/S ratio) and the results ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001108
更新日期:2016-06-01 00:00:00
abstract::Hepatic epithelioid angiomyolipoma (AML) is rare. Although generally epithelioid AML shows benign biological behavior, it can occasionally have malignant potential. In this study, we report a case of 2 hepatic epithelioid AMLs with different F-FDG uptake; one is intensely FDG avid, and the other is non-FDG avid. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002048
更新日期:2018-06-01 00:00:00
abstract::Serial radionuclide angiography is a sensitive technique for the identification of asymptomatic cardiac dysfunction secondary to doxorubicin hydrochloride chemotherapy. However, the results of serial studies must be interpreted with caution in order to avoid labeling variations in the left ventricular ejection fractio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198808000-00002
更新日期:1988-08-01 00:00:00
abstract:INTRODUCTION:I-FP-CIT SPECT is increasingly used to differentiate between Alzheimer's dementia (AD) and dementia with Lewy bodies (DLB). The role of I-FP-CIT SPECT in frontotemporal dementia (FTD) is rather unclear, albeit nigrostriatal involvement may occur. The aim of this study was to evaluate its role in the differ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000554
更新日期:2015-01-01 00:00:00
abstract::A 51-year-old man presented with cough and pain in his upper chest for 1 week. Chest CT showed an ill-defined right paratracheal mass with slight enhancement in the upper mediastinum. A FDG PET/CT was performed showing focal increased FDG uptake with SUVmax of 4.7 in the mass. The mass was excised surgically. Histopat...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002860
更新日期:2020-02-01 00:00:00
abstract::Twenty-eight children (5 girls, 23 boys; age, 20.3 +/- 16.2 months) with Kawasaki disease (KD) were included in this study. The children were treated with aspirin plus intravenous injection of gamma globulin (IVGG). Both Tc-99m HMPAO labeled WBC heart imaging (Tc-WBC) and two-dimensional echocardiograms (2D-Echo) were...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199509000-00012
更新日期:1995-09-01 00:00:00
abstract:AIM:The aim of this study was to retrospectively analyze the prognostic value of combined Tc-macroaggregated albumin (MAA) SPECT/CT and [F]-fluoroethylcholine (FEC) PET/CT before radioembolization for survival of patients with intermediate-stage hepatocellular carcinoma. METHODS:Twenty-four patients with known hepatoc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002092
更新日期:2018-07-01 00:00:00
abstract::An adenoid cystic carcinoma of salivary gland origin metastasized to the abdomen four years after the initial diagnosis. It showed heavy uptake of Ga-67 citrate and hypervascularity. The clinical and pathologic features are discussed. Gallium scan and arteriography (usually external carotid artery injection) may prove...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198507000-00009
更新日期:1985-07-01 00:00:00
abstract::After a total or near total thyroidectomy and radioiodine ablation therapy for differential thyroid cancer (DTC), routine follow-up methods are (131)I or (131)I whole-body scanning (WBS) as well as serum thyroglobulin (Tg) and anti-thyroglobulin (anti-Tg) levels. We describe a case of a 41-year-old woman with follicul...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182814c4d
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Patients with squamous cell carcinoma of the head and neck have been reported to have a high rate of second primary cancer of the upper aerodigestive tract. This study was performed to determine whether positron emission tomography/computed tomography (PET/CT) is useful for detecting a second primary cancer aft...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31818bf27d
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To evaluate indirect findings of cerebrospinal fluid (CSF) leakage on radionuclide cisternography and their changes after treatment. MATERIALS AND METHODS:This study was approved by the hospital's institutional review board and informed consent was obtained before each examination. A total of 67 patients who w...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318162d955
更新日期:2008-03-01 00:00:00
abstract::Hemangiomas are easily, quickly and relatively noninvasively detected using whole-body imaging with Tc-99m labeled RBCs. A case in which this method was used to confirm known lesions and detect additional unsuspected lesions is described. This method can also be useful in the detection and evaluation of other types of...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198610000-00012
更新日期:1986-10-01 00:00:00
abstract::Previous reports have indicated an accuracy of nearly 100% for LeVeen shunt studies. A case is presented that fulfills the criteria for proper function, but the LeVeen shunt tube was poorly functioning with its tip partially extravascular. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198507000-00008
更新日期:1985-07-01 00:00:00
abstract::This is a report of a patient who underwent high-resolution brain perfusion SPECT studies during and after an episode of transient global amnesia. During the attack, SPECT imaging showed increased perfusion in the left medial temporal region involving the amygdala and hippocampus. After recovery from amnesia, a follow...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199301000-00011
更新日期:1993-01-01 00:00:00
abstract::A 55-year old woman presented in an obtunded state and was found to have a subarachnoid hemorrhage. After endovascular repair, her condition deteriorated, and brain death was suspected. A Tc bicisate brain blood flow study was performed, which showed a complete absence of blood flow to the cerebellum despite intact ci...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001866
更新日期:2017-12-01 00:00:00
abstract::The purpose of this report was to determine the pattern of thallium (T1-201) uptake in pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCTTS) and to evaluate for features that might help to distinguish these lesions from malignant disease. Scintigraphic images from patients subsequen...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093083.77866.5c
更新日期:2003-11-01 00:00:00
abstract::A child with an asymptomatic mass in the lower right thorax was evaluated with sonography, intravenous urography, and radionuclide renography. High renal ectopia was only diagnosed with radionuclide renography. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00004
更新日期:1983-09-01 00:00:00
abstract::A 38-year-old woman presented with nausea and abdominal distension 15 months after surgical resection of osteoclast-like giant cell tumor in the left lobe of the liver. An 18F-FDG PET/CT scan was performed to evaluate the recurrent tumor. The images demonstrated the recurrent malignancy in the liver. In addition, meta...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31826392c4
更新日期:2012-10-01 00:00:00