Radionuclide evaluation of doxorubicin cardiotoxicity: the need for cautious interpretation.

Abstract:

:Serial radionuclide angiography is a sensitive technique for the identification of asymptomatic cardiac dysfunction secondary to doxorubicin hydrochloride chemotherapy. However, the results of serial studies must be interpreted with caution in order to avoid labeling variations in the left ventricular ejection fraction (LVEF) due to artifact as doxorubicin cardiotoxicity. The use of sequential gated cardiac studies in the evaluation of a thirteen-year-old boy on doxorubicin hydrochloride is presented. Reassessment of the results of these studies showed that technical and biologic factors were the cause of recurring fluctuations in the LVEF, rather than drug toxicity.

journal_name

Clin Nucl Med

authors

Dey HM,Kassamali H

doi

10.1097/00003072-198808000-00002

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

565-8

issue

8

eissn

0363-9762

issn

1536-0229

journal_volume

13

pub_type

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