Abstract：
INTRODUCTION:Gastrointestinal (GI) motility disorders include many clinical manifestations associated with various pathologies. They are widespread and can be considered a primary symptom or can be associated to other diseases, such as Parkinson's disease. Understanding the type and site of GI dysmotility is crucial to identify the functional abnormality and to unravel the underlying mechanisms, in order to design adequate therapeutic interventions. METHODS:In the present study, we applied radiological analysis, a common tool in clinical practice, to follow up in vivo the progression of GI dysmotility over time and along the entire GI tract in an animal model of central nervous dopaminergic degeneration and compared these results to those obtained with standard techniques commonly used to assess GI motor functions in small rodents. RESULTS:Our radiological data, showing delayed gastric emptying and constipation, agree with and expand previous information obtained with other functional assays in the same model, suggesting that radiological analysis can be an appropriate method to explore GI dysmotility in animal models of human pathologies. DISCUSSION:In this study we have applied for the first time the GI radiological analysis to an animal model of central nervous dopaminergic degeneration providing a non-invasive/animal-preserving approach, ethically more acceptable and useful to follow up the development of GI dysmotility in pathologies evolving over time.
journal_name
J Pharmacol Toxicol Methodsjournal_title
Journal of pharmacological and toxicological methodsauthors
Vegezzi G,Al Harraq Z,Levandis G,Cerri S,Blandini F,Gnudi G,Miduri F,Blandizzi C,Domenichini G,Bertoni S,Ballabeni V,Barocelli Edoi
10.1016/j.vascn.2014.08.003subject
Has Abstractpub_date
2014-09-01 00:00:00pages
163-9issue
2eissn
1056-8719issn
1873-488Xpii
S1056-8719(14)00244-5journal_volume
70pub_type
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journal_title：Journal of pharmacological and toxicological methods
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journal_title：Journal of pharmacological and toxicological methods
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