Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate.

Abstract:

OBJECTIVES:Demineralized lesions in tooth enamel around orthodontic brackets are caused by acids from cariogenic biofilm. This study aimed to develop a novel antibacterial orthodontic cement by incorporating a quaternary ammonium monomer dimethylaminododecyl methacrylate (DMADDM) into a commercial orthodontic cement, and to investigate the effects on microcosm biofilm response and enamel bond strength. METHODS:DMADDM, a recently-synthetized antibacterial monomer, was incorporated into orthodontic cement at 0%, 1.5%, 3% and 5% mass fractions. Bond strength of brackets to enamel was measured. A microcosm biofilm model was used to measure metabolic activity, lactic acid production, and colony-forming units (CFU) on orthodontic cements. RESULTS:Shear bond strength was not reduced at 3% DAMDDM (p > 0.1), but was slightly reduced at 5% DMADDM, compared to 0% DMADDM. Biofilm viability was substantially inhibited when in contact with orthodontic cement containing 3% DMADDM. Biofilm metabolic activity, lactic acid production, and CFU were much lower on orthodontic cement containing DMADDM than control cement (p < 0.05). CONCLUSIONS:Therefore, the novel antibacterial orthodontic cement containing 3% DMADDM inhibited oral biofilms without compromising the enamel bond strength, and is promising to reduce or eliminate demineralization in enamel around orthodontic brackets.

journal_name

J Dent

journal_title

Journal of dentistry

authors

Melo MA,Wu J,Weir MD,Xu HH

doi

10.1016/j.jdent.2014.07.006

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1193-201

issue

9

eissn

0300-5712

issn

1879-176X

pii

S0300-5712(14)00209-7

journal_volume

42

pub_type

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