Abstract：
:Complex Regional Pain syndrome type I (CRPS-I) is a disease characterised by extreme pain for which no gold-standard treatment exists to date. In recent years a possible role for bisphosphonates in the treatment of CRPS-I has been proposed. These drugs were first used for their effect in decreasing pain in bone diseases in which bisphosphonates act through their antiosteoclastic properties (metastatic disease, Paget disease, myeloma). In CRPS-I, enhanced osteoclastic activity has never clearly been demonstrated and the benefit shown is possibly exerted by different mechanisms of action. In this paper we review other conjectural mechanisms involved in reducing pain intensity and improving clinical signs and functional status in these patients. The results of most studies on this topic show that bisphosphonates may be effective in the early phases of the disease, when scintigraphic bone scan more frequently shows a local radiotracer accumulation that possibly means a high local concentration of the drug. These features probably represent the required conditions by which bisphosphonates might modulate various inflammatory mediators that are upregulated in CRPS-I. Patients in whom a scintiscan is often negative (long-standing disease or a primarily cold disease) could be less responsive to this treatment. With these limitations, bisphosphonates appear to present a therapeutic strategy that has been proven to reliably offer benefits in patients with CRPS-I.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Varenna M,Adami S,Sinigaglia Lsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
451-4issue
4eissn
0392-856Xissn
1593-098Xpii
8025journal_volume
32pub_type
社论,评审abstract：OBJECTIVE:To examine the links between the quality of life (QOL) and season and weather conditions in ankylosing spondylitis (AS) patients. METHODS:A cohort of 146 AS patients (67% males), with a mean age of 47.3 years and a mean disease duration of 12.8 years, answered a self-administered questionnaire, the AS-AIMS2 ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVES:To investigate the efficacy and safety of low-dose etanercept treatment after clinical remission of ankylosing spondylitis (AS) in the real world. METHODS:Data on 134 AS patients who were treated with etanercept for more than 12 months and achieved clinical remission (BASDAI<4 and CRP<0.5 mg/dL) were extrac...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-07-01 00:00:00
abstract：:Only a few observations of inflammatory arthritis have been associated with Down's syndrome. We report a case of severe erosive, peripheral and axial psoriatic arthritis associated with cutaneous vasculitis in a 24-year old man with trisomy 21. A long standing remission of vasculitis and arthritis was achieved with co...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:This review article discusses the aspects of sports medicine where musculoskeletal Doppler ultrasound has valuable contribution in diagnosis and/or treatment of some of the typical musculoskeletal sports injuries. Also, conditions where the Doppler ultrasound has no value are discussed. Some guidelines and recommendat...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Appendicitis was diagnosed in a 38-year-old patient with seropositive rheumatoid arthritis. Despite appendectomy the patient's clinical condition deteriorated. Thorough microscopical evaluation of the pathological anatomical specimens from the appendix made possible a diagnosis of necrotizing vasculitis. The systemic ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Autoimmune thyroid disease is common in patients with either systemic lupus erythematosus (SLE) or Sjögren's syndrome (SS); however, whether the risk is greater than in well matched controls is not clear. Antinuclear antibodies are found in the sera of patients with autoimmune thyroid disease, but there is no evidence...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVES:Recently, research has been focused on the identification of predictors of response to treatment in patients with active psoriatic arthritis (PsA). The objective of this study was to develop a model to predict the clinical response at 6 months in patients with PsA starting the anti-tumour necrosis factor-α g...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:During the last decade, antiphospholipid antibodies and their clinical manifestations have given rise to increasing interest and have been associated with a wide spectrum of clinic expression, including arterial and venous thrombosis, thrombocytopenia, recurrent fetal wastage, Coombs positive haemolysis, livedo reticu...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1993-11-01 00:00:00
abstract：:An open-label, one-year study was conducted to evaluate the safety and clinical response to leflunomide and methotrexate combination therapy for rheumatoid arthritis. Study results revealed tolerable safety, no significant pharmacokinetic interactions between methotrexate and leflunomide, and suggested improved clinic...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Patients with ankylosing spondylitis (AS) may develop cardiovascular manifestations ranging from asymptomatic forms to life threatening conditions. The most important cardiovascular manifestation of AS is aortitis, which frequently involves the aortic root and the ascending aorta leading to valvular insufficiency. The...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：:Pure red cell aplasia (PRCA) is an acute anemia due to selective suppression of erythropoiesis. We report a case of PRCA diagnosed before the onset of primary Sjögren's syndrome (SS). A young woman, with autoimmune thyroiditis, developed polyarthritis with ANA and Rheumatoid factor positivity, diagnosed as Rheumatoid ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:Lymphocyte subpopulations and functions were examined in the salivary (parotid) gland lymphocytes (SGL) obtained as a cell suspension from a patient with Sjögren's syndrome associated with rheumatoid arthritis, in comparison with peripheral blood lymphocytes (PBL). Serial studies on the lymphocyte subsets in PBL using...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVES:We evaluated age at natural menopause and the prevalence of premature ovarian failure (POF) in a monocentric Caucasian cohort of patients with systemic lupus erythematosus (SLE). METHODS:In this cross-sectional study, we enrolled women affected by SLE compared with healthy controls (HC) to investigate data ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：:This is a literature review on the efficacy and toxicity of low dose weekly methotrexate treatment in rheumatoid arthritis. Personal recommendations on dosing and monitoring (of) the drug are given. ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To determine the serum levels of galectin-3 (Gal-3) and galectin-3 binding protein (G3BP) and to evaluate the associations between clinical features and these levels in patients with Behçet's disease (BD). METHODS:Fifty patients with BD (mean age 40.6 +/- SEM 1.4 years; 21 males, 29 females; 26 active and 24...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVES:Neurosarcoidosis (NS) and primary angiitis of central nervous system (PACNS) are inflammatory diseases affecting central nervous system, with overlapping clinical and pathological characteristics. Distinguishing these diseases is important given distinct therapeutic implications. In this study, we aimed to c...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:Essential mixed cryoglobulinaemia (EMC) is a disorder of B-cells producing rheumatoid factor (RF), and is clinically and immunologically similar to mixed cryoglobulinaemia (MC) related to hepatitis C virus (HCV-MC). We report here the first comprehensive analysis of B-cell clonality, phenotype and function i...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Offspring of a cross between the NZB and NZW mice (F1) develop a disease similar to SLE in humans. Female mice of the F1 strain develop the disease at a younger age and die earlier than the males. In order to test the hypothesis that estrogen receptor concentrations in the lymphoid organs of these mice may correlate w...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:A six-item questionnaire regarding sicca symptoms recently validated for primary Sjögren's syndrome (SS) was tested on 154 in-patients with a wide range of inflammatory rheumatic diseases. Patients with one or more positive responses underwent objective ocular and oral diagnostic procedures. Of 27 patients th...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVES:We propose a GCA probability score intended to help to risk-stratify patients referred by general practitioners with suspected GCA into those with high probability of GCA versus low probability of GCA. In this pilot study we evaluated the diagnostic accuracy of this proposed scoring system. METHODS:A scorin...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVES:Patients diagnosed with systemic sclerosis (SSc) report a high need for education and support. To address these needs, a short, group-based psycho-educational programme for patients with SSc was developed and evaluated. METHODS:A pre-post test design was utilised. Participants completed questionnaires on ph...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:Cryopyrin-associated periodic syndromes (CAPS) comprise a spectrum of distinct, rare, autosomal dominant autoinflammatory disorders of increasing severity caused by NLRP3 gene mutations. METHODS:We describe a 13-year-old female who presented, in the initial phase of the disease, recurrent episodes of high f...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The cytokine profile suggests that giant cell arteritis (GCA) is a Th1-driven disease, in which local IFN-gamma plays a critical role in the development of a systemic arteritis. IL-12 is a potent inducer of IFN-gamma and is critically involved in biasing an immune response towards a Th1 pathway. The purpose o...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To document the psychological side effects of methotrexate (MTX) treatment in children with juvenile idiopathic arthritis (JIA) and to explore the usefulness of psychological therapy to ameliorate these side effects. METHODS:The patients included in this study consisted of 29 patients with JIA using MTX. Of ...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:There is a definite association of heart disease with ankylosing spondylitis (AS). The magnitude of this relationship is less clear. Three types of inflammatory affections can be differentiated: 1. aortitis and aortic insufficiency with the possible necessity of cardiac surgery, 2. conduction disturbances of the atrio...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:There is no information on how patella cartilage relates to the radiological grade of individual features of patellofemoral osteoarthritis (osteophytes or joint space narrowing) which have been used in most epidemiological and clinical studies. In this study we compared patella cartilage volume as measured b...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVES:Tocilizumab (TCZ) is an effective treatment in patients with rheumatoid arthritis (RA) refractory to anti-tumour necrosis factor-α. However, only few studies in real life have evaluated the efficacy of TCZ in long-standing rheumatoid arthritis (LSRA). Our aim was to evaluate the efficacy and safety of tocili...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To evaluate if methotrexate (MTX) can slow disease progression, as determined radiographically, in comparison to other disease modifying drugs in rheumatoid arthritis (RA) patients. MATERIALS AND METHODS:Pairs of hand and wrist radiographs from 30 patients treated with MTX and 30 treated with D-penicillamine...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-05-01 00:00:00
abstract：:A young female patient who had documented seropositive rheumatoid arthritis and was treated consecutively with aspirin, diclofenac, and gold salts was admitted years later for severe neutropenia. On examination she had, in addition, fever, positive rheumatoid factor, reversible swan-neck deformity of the fingers but o...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To assess circulating immunoregulatory cytokines and soluble surface markers of T and B cell activation in the plasma of patients with Wegener's granulomatosis (WG), Churg-Strauss syndrome (CSS) and microscopic polyangiitis (MPA) during active and inactive disease, in order to establish their value in discrim...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
