Factors that mediate colonization of the human stomach by Helicobacter pylori.

Abstract:

:Helicobacter pylori (H. pylori) colonizes the stomach of humans and causes chronic infection. The majority of bacteria live in the mucus layer overlying the gastric epithelial cells and only a small proportion of bacteria are found interacting with the epithelial cells. The bacteria living in the gastric mucus may act as a reservoir of infection for the underlying cells which is essential for the development of disease. Colonization of gastric mucus is likely to be key to the establishment of chronic infection. How H. pylori manages to colonise and survive in the hostile environment of the human stomach and avoid removal by mucus flow and killing by gastric acid is the subject of this review. We also discuss how bacterial and host factors may together go some way to explaining the susceptibility to colonization and the outcome of infection in different individuals. H. pylori infection of the gastric mucosa has become a paradigm for chronic infection. Understanding of why H. pylori is such a successful pathogen may help us understand how other bacterial species colonise mucosal surfaces and cause disease.

journal_name

World J Gastroenterol

authors

Dunne C,Dolan B,Clyne M

doi

10.3748/wjg.v20.i19.5610

subject

Has Abstract

pub_date

2014-05-21 00:00:00

pages

5610-24

issue

19

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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