Abstract:
:Protein homeostasis in the endoplasmic reticulum (ER) in eukaryotic cells is maintained by a conserved quality control system named ER-associated degradation (ERAD). The ERAD system retains misfolded or unassembled polypeptides in the ER, retrotranslocates them into the cytosol for degradation by the ubiquitin proteasome system. Central to the ERAD process is the AAA+ (ATPase associated with various cellular activities), ATPase p97/VCP (also known as Cdc48p in yeast), and the proteasome. p97/VCP couples ATP hydrolysis to the extraction of misfolded proteins from retrotranslocation sites and subsequently targets them for degradation, but how p97/VCP hands substrate off to the proteasome is unclear. Recent studies suggest that p97/VCP may either directly translocate polypeptides into the proteolytic compartment of the 20S subcomplex, or use a set of shuttling factors to deliver retrotranslocated polypeptides to the proteasome.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Zhang T,Ye Ydoi
10.1089/dna.2014.2452subject
Has Abstractpub_date
2014-08-01 00:00:00pages
477-83issue
8eissn
1044-5498issn
1557-7430journal_volume
33pub_type
杂志文章,评审abstract::The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2007.0586
更新日期:2007-08-01 00:00:00
abstract::2-Arylbenzothiazoles are an important class of bicyclic privileged substructures present in various natural or synthetic compounds that have been shown to possess anticancer, antifungal, antibacterial, anti-inflammatory, and antiallergic activities. This study examined the antiproliferative properties of 2-(3,5-dihydr...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1363
更新日期:2012-03-01 00:00:00
abstract::Porifera (sponges) constitute the lowest metazoan phylum. Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454999314746
更新日期:1999-12-01 00:00:00
abstract::Interferon gamma (IFN-γ) is one of the key cytokines that plays a major role against viral and intracellular bacterial infection. In addition to the IFN-γ gene, teleost fish possess a second copy known as IFN-γ-related (IFN-γrel) gene. This report describes structural and functional properties of IFN-γrel gene in the ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2656
更新日期:2015-05-01 00:00:00
abstract::Hepatic fibrosis is a reversible process involving plenty of transcription factors and pathways. Vitamin D receptor (VDR) as a member of ligand-induced transcription factors can interact with 9-cis retinoid X receptor (RXR) and VDR-interacting repressor (VDIR) to mediate transactivation or transrepression in the absen...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2016.3367
更新日期:2016-09-01 00:00:00
abstract::Several reports have suggested the importance of p73 polymorphisms in tumor behavior. We investigated the role of a p73 gene polymorphism in the susceptibility to cervical lesions in a southwestern European population. Peripheral blood samples were obtained from Radiotherapy and Gynaecology Departments of Portuguese I...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1294
更新日期:2012-02-01 00:00:00
abstract::NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1115
更新日期:2011-05-01 00:00:00
abstract::Recently, we demonstrated that the DAN gene product contains a growth- and/or a tumor-suppressive activity in vitro. In the present work, using a yeast two-hybrid system, we searched for cellular proteins that can associate with the DAN gene product. A cDNA clone, termed DA41, was initially isolated from an adult rat ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1997.16.985
更新日期:1997-08-01 00:00:00
abstract::CONSTANS (CO)/CONSTANS-like (COL) genes that have been studied in annual model plants such as Arabidopsis thaliana and Oryza sativa play key roles in the photoperiodic flowering pathway. Moso bamboo is a perennial plant characterized by a long vegetative stage and flowers synchronously followed by widespread death. Ho...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2018.4611
更新日期:2019-07-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454900314564
更新日期:2000-03-01 00:00:00
abstract::Osteosarcoma is one of the most common primary malignant tumors of the bone and tends to develop in teenage years. Although multitreatments for the diagnosis and therapy of osteosarcoma have been developed, there are still needs of new methods to prevent and treat the osteosarcoma. Here, we performed bioinformatic ana...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5377
更新日期:2020-07-01 00:00:00
abstract::The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 ex...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5644
更新日期:2020-10-01 00:00:00
abstract::The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1992.11.721
更新日期:1992-12-01 00:00:00
abstract::NANOG is a critical homeodomain transcription factor responsible for maintaining embryonic stem cell (ESC) self-renewal and pluripotency. In the present study, we isolated, sequenced, and characterized the NANOG gene in buffalo ESC-like cells. Here, we demonstrated that NANOG mRNA is expressed as multiple isoforms and...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1410
更新日期:2012-05-01 00:00:00
abstract::The aim of this article is to review our current understanding of the role of cytokines, chemokines, T cells, Langerhans cells, and neutrophils (PMN) and their interactions in vivo in the host response to Pseudomonas aeruginosa ocular challenge. The cellular/cytokine network in vivo has begun to be unraveled, and the ...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/10445490260099665
更新日期:2002-05-01 00:00:00
abstract::The role of p53 in mediating nitric oxide (NO)-induced cell death remains uncertain. The exogenous NO donor S-nitrosoglutathione (GSNO) produced a concentration-dependent reduction in cell viability in embryonic chick cardiomyocytes in culture. Western blotting and immunocytochemistry for p53 showed that p53 was incre...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2007.0576
更新日期:2007-07-01 00:00:00
abstract::Promoter elements located up to 2 kb upstream of the apolipoprotein A-I (apoA-I) gene are necessary for apoA-I expression in liver and intestine cells in tissue culture. In transgenic mice, a distal enhancer located between the apoA-IV and apoC-III genes is additionally necessary for tissue-specific expression of apoA...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454999315493
更新日期:1999-02-01 00:00:00
abstract::Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could partially recover T cel...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2015.2810
更新日期:2015-07-01 00:00:00
abstract::To investigate the contribution of de novo variants to Tourette disorder (TD) probands in China. Whole-exome sequencing (WES) conducted on 15 child-parent trios (45 samples) detected 25 coding de novo variants, including 2 de novo Likely Gene Disrupting (LGD) variants and 6 Missense3 variants. The de novo LGD variants...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2019.4746
更新日期:2020-01-01 00:00:00
abstract::The HIV-1 regulatory proteins Tat and Rev and the accessory proteins Vpr, Vpu, and Vif are essential for viral replication, and their cytoplasmic production suggests that they should be processed for recognition by cytotoxic T lymphocytes. However, only limited data is available evaluating to which extent these protei...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454902760330219
更新日期:2002-09-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) may serve as potential molecular diagnostic markers to improve the capacity of earlier and more accurate diagnosis of dilated cardiomyopathy (DCM). We integrated five independent transcriptomic datasets (n = 504) from Gene Expression Omnibus for systematic identification of lncRNA-based d...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5670
更新日期:2020-11-03 00:00:00
abstract::MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of cellular functions through post-transcriptional regulations on target genes. Common genetic variants (single-nucleotide polymorphisms, SNPs) in pre-miRNA genes may alter their expression and/or maturation effe...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1159
更新日期:2011-06-01 00:00:00
abstract::Human immunodeficiency virus type I (HIV-1) infection leads to penetration of the central nervous system (CNS) in virtually all infected individuals and HIV-1-induced encephalopathy in a significant number of untreated patients. The molecular mechanisms by which HIV-1 enters the CNS and yields CNS dysfunction are stil...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/104454904773819815
更新日期:2004-04-01 00:00:00
abstract::Insulin-like growth factor I (IGF-I) plays a major role in development and metabolism. Currently, the cDNA-derived primary structure of IGF-I is known for some mammals and for chicken, frog, and salmon. Additionally, the organization of the human, rat, and chicken IGF-I genes has been established. The investigation of...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1993.12.729
更新日期:1993-10-01 00:00:00
abstract::The pathogenic strains of Vibrio cholerae that cause acute enteric infections in humans are derived from environmental nonpathogenic strains. To track the evolution of pathogenic V. cholerae and identify potential precursors of new pathogenic strains, we analyzed 324 environmental or clinical V. cholerae isolates for ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0737
更新日期:2008-07-01 00:00:00
abstract::Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1333
更新日期:2012-03-01 00:00:00
abstract::Our previous study showed that the mutation hotspots of the K-ras proto-oncogene in human functional adrenocortical tumors are in codons 15, 16, 18, and 31, thus differing from the sites in other tumors. In addition, analyzing the K-Ras protein by a recombinant DNA technique showed that the activity of endogenic GTPas...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454901750219116
更新日期:2001-04-01 00:00:00
abstract::The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines is altered in the Helicobacter pylori-infected gastric mucosa. Therefore, we aimed to evaluate the association of functional promoter variants of transforming growth factor (TGF)-B1 and matrix metalloproteinase (MMP)-7 genes with ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0842
更新日期:2009-06-01 00:00:00
abstract::The search for new chemotherapeutics unaffected by efflux pumps would significantly increase life expectancy in patients with malignant cancers. In this study, butylcycloheptylprodigiosin and undecylprodigiosin were HPLC-purified and verified, using nuclear magnetic resonance spectroscopy. Cell cytotoxicity and transp...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2018.4161
更新日期:2018-06-01 00:00:00
abstract::Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2202
更新日期:2014-04-01 00:00:00