Abstract:
:The aberrant expression of myeloid antigen CD66 on acute B-lymphoblastic leukemia (B-ALL) cells is a well-documented phenomenon. CD66a is a major subtype of the CD66 family which plays a dual role in different cancers, and the contradictory effect may depend on the isoform ratio of CD66a-4L to CD66a-4S. Although the abnormal expression of CD66a on leukemic B-cells has been reported widely, little is known about the biological function of this aberrant expression. In this study, we showed that inhibition of CD66a in human B-ALL cell lines reduced the cellular proliferative rate and increased the percentage of cellular apoptosis, and the ratio of CD66a-4L to CD66a-4S in leukemic B cells is much higher than that in granulocytes. In addition, alteration of the L:S ratio by silencing and overexpressing the L isoform in B-ALL cell lines confirmed that a high L:S ratio of CD66a in leukemic B cells promotes proliferation and inhibits FasL-induced apoptosis.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Zhao W,Zhang Y,Liu D,Zhong L,He Q,Zhao Ydoi
10.3109/10428194.2014.913287subject
Has Abstractpub_date
2015-01-01 00:00:00pages
202-10issue
1eissn
1042-8194issn
1029-2403journal_volume
56pub_type
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