Estimating volumes of the pituitary gland from T1-weighted magnetic-resonance images: effects of age, puberty, testosterone, and estradiol.

Abstract:

:The pituitary gland is a key structure in the hypothalamic-pituitary-gonadal (HPG) axis--it plays an important role in sexual maturation during puberty. Despite its small size, its volume can be quantified using magnetic resonance imaging (MRI). Here, we study a cohort of 962 typically developing adolescents from the Saguenay Youth Study and estimate pituitary volumes using a newly developed multi-atlas segmentation method known as the MAGeT Brain algorithm. We found that age and puberty stage (controlled for age) each predicts adjusted pituitary volumes (controlled for total brain volume) in both males and females. Controlling for the effects of age and puberty stage, total testosterone and estradiol levels also predict adjusted pituitary volumes in males and pre-menarche females, respectively. These findings demonstrate that the pituitary gland grows during adolescence, and its volume relates to circulating plasma-levels of sex steroids in both males and females.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Wong AP,Pipitone J,Park MTM,Dickie EW,Leonard G,Perron M,Pike BG,Richer L,Veillette S,Chakravarty MM,Pausova Z,Paus T

doi

10.1016/j.neuroimage.2014.02.030

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

216-221

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(14)00143-8

journal_volume

94

pub_type

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