Abstract：
:Even in the absence of stimulation or task, the cerebral cortex shows an incessant pattern of ultra slow fluctuations which are coherent across brain regions. In the healthy brain these coherent patterns (also termed resting state functional connectivity) often exhibit spatial similarity to the large scale organization of task-induced functional networks. However, it is not clear to what extent the resting state patterns can also reflect task-induced abnormalities in cortical activations which are often detected in various brain pathologies. Here we examined whether an abnormal visual activation pattern is recapitulated in the resting state functional connectivity. We examined LG, a sighted young adult with developmental object agnosia and no apparent cortical structural abnormality. We have previously reported that upon visual stimulation, LG's intermediate visual areas (V2, V3) are paradoxically deactivated. Here, examining LG's resting state functional connectivity revealed the same pattern of functional abnormality - including a strong atypical decorrelation between areas V2-V3 and the rest of the visual system. Thus, our results suggest that resting-state functional connectivity could provide a powerful tool which could complement task-specific paradigms in detecting task-related abnormalities in cortical activity without resorting to task performance.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Gilaie-Dotan S,Hahamy-Dubossarsky A,Nir Y,Berkovich-Ohana A,Bentin S,Malach Rdoi
10.1016/j.neuroimage.2012.12.049subject
Has Abstractpub_date
2013-04-15 00:00:00pages
189-98eissn
1053-8119issn
1095-9572pii
S1053-8119(12)01235-9journal_volume
70pub_type
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