Visually evoked gamma responses in the human brain are enhanced during voluntary hyperventilation.

Abstract:

:Hypocapnia induced by hyperventilation (HV) has powerful effects on neuronal excitability and synaptic transmission. We have studied the effect of hyperventilation on the phase-locked oscillatory components of the evoked responses in the human brain. We recorded visually evoked magnetoencephalographic responses before, during, and after voluntary hyperventilation to pattern-reversal checkerboard stimuli. Gamma-band (30-45 Hz) responses phase-locked to the stimuli were generated in the occipital visual cortex. A wavelet-based time-frequency analysis revealed that the gamma responses increased during HV whereas their frequency did not change significantly. A recent in vitro study in the rat hippocampus demonstrated that the stability of spontaneous gamma activity increases during hypocapnia as a result of enhanced GABAergic transmission. To test if a similar mechanism could account for our findings, we performed simulations on a network of 100 Hodgkin-Huxley neurons connected by inhibitory synapses. We found that enhanced GABA(A) transmission, paired with enhanced excitability, can explain the increase in evoked gamma activity without changing the frequency.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Jensen O,Hari R,Kaila K

doi

10.1006/nimg.2001.1013

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

575-86

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053811901910134

journal_volume

15

pub_type

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