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The development of brain white matter microstructure.

Abstract：

:Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes. Processes including myelination and synaptogenesis occur rapidly across the first 2-3 years of life, and ongoing brain remodeling continues into young adulthood. Studies have sought to characterize the patterns of structural brain development, and early studies predominately relied upon gross anatomical measures of brain structure, morphology, and organization. MRI offers the ability to characterize and quantify a range of microstructural aspects of brain tissue that may be more closely related to fundamental neurodevelopmental processes. Techniques such as diffusion, magnetization transfer, relaxometry, and myelin water imaging provide insight into changing cyto- and myeloarchitecture, neuronal density, and structural connectivity. In this review, we focus on the growing body of literature exploiting these MRI techniques to better understand the microstructural changes that occur in brain white matter during maturation. Our review focuses on studies of normative brain development from birth to early adulthood (∼25 years), and places particular emphasis on longitudinal studies and newer techniques that are being used to study microstructural white matter development. All imaging methods demonstrate consistent, rapid microstructural white matter development over the first 3 years of life, suggesting increased myelination and axonal packing. Diffusion studies clearly demonstrate continued white matter maturation during later childhood and adolescence, though the lack of consistent findings in other modalities suggests changes may be mainly due to axonal packing. An emerging literature details differential microstructural development in boys and girls, and connects developmental trajectories to cognitive abilities, behaviour, and/or environmental factors, though the nature of these relationships remains unclear. Future research will need to focus on newer imaging techniques and longitudinal studies to provide more detailed information about microstructural white matter development, particularly in the childhood years.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Lebel C,Deoni S

doi

10.1016/j.neuroimage.2017.12.097

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

207-218

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)31121-7

journal_volume

182

pub_type

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The development of brain white matter microstructure.