Abstract:
BACKGROUND:Creutzfeldt-Jakob disease is a rapidly progressive, fatal, transmissible neurodegenerative disorder caused by prion protein. It is still considered rare in countries like India. This is probably due to nonavailability of autopsy studies in majority of the center. The recent European diagnostic criterion for sporadic CJD (sCJD) is useful for making an early diagnosis. OBJECTIVE:To report a series of patients of probable sCJD from a neurology institute of eastern India. MATERIALS AND METHODS:Patients of rapidly developing dementia fulfilling the diagnostic criteria for sCJD were included. All were investigated in detail to find out any possible treatable cause including electroencephalography (EEG), magnetic resonance imaging (MRI) of brain, and cerebrospinal fluid analysis. RESULTS:A total 10 patients of probable sCJD diagnosed using the European diagnostic criterion between December 2011 and January 2013. The clinical features are consistent with other reported series. While 60% of patients had the classical EEG findings, 100% had typical MRI features. Eight patients died within a mean duration of 4.56 months from the disease onset. CONCLUSIONS:The clinical features are similar to other reported series. Our observation raises question about the prevalence of this disease in India which needs more elaborate studies.
journal_name
Ann Indian Acad Neuroljournal_title
Annals of Indian Academy of Neurologyauthors
Biswas A,Khandelwal N,Pandit A,Roy A,Guin DS,Gangopadhyay G,Senapati Adoi
10.4103/0972-2327.120486subject
Has Abstractpub_date
2013-10-01 00:00:00pages
659-63issue
4eissn
0972-2327issn
1998-3549pii
AIAN-16-659journal_volume
16pub_type
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_357_19
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.176866
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.85900
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.64645
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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