Abstract:
:Eukaryotic cells can adapt to endoplasmic reticulum (ER) dysfunction by producing diverse signals from the ER to the cytosol or nucleus. These signaling pathways are collectively known as the unfolded protein response (UPR). The canonical branches of the UPR are mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6). These ER stress transducers basically play important roles in cell survival after ER stress. Recently, novel types of ER stress transducers that share a region of high sequence similarity with ATF6 have been identified. They have a transmembrane domain, which allows them to associate with the ER, and possess a transcription-activation domain and a basic leucine zipper (bZIP) domain. These membrane-bound bZIP transcription factors include OASIS, BBF2H7 CREBH, CREB4 and Luman, and are collectively referred to as OASIS family members. Despite their structural similarities with ATF6, differences in activating stimuli and tissue distribution indicate specialized functions of each member on regulating UPR signaling in specific organs and tissues. One of them, OASIS, is expressed preferentially in astrocytes in the central nervous system (CNS). OASIS temporally regulates the differentiation from neural precursor cells into astrocytes to promote the expression of Glial Cell Missing 1 through dynamic interactions among OASIS family members followed by accelerating demethylation of the Gfap promoter. This review is a summary of our current understanding of the physiological functions of OASIS in the CNS.
journal_name
Anat Sci Intjournal_title
Anatomical science internationalauthors
Saito Adoi
10.1007/s12565-013-0214-xsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
11-20issue
1eissn
1447-6959issn
1447-073Xjournal_volume
89pub_type
杂志文章,评审abstract::For a long time, because of its location at the skull base level, the sphenoid bone was rather mysterious as it was too difficult for anatomists to reach and to elucidate its true configuration. The configuration of the sphenoid bone led to confusion regarding its sutures with the other skull bones, its shape, its det...
journal_title:Anatomical science international
pub_type: 杂志文章,评审
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-014-0227-0
更新日期:2014-09-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-009-0062-x
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-018-0431-4
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journal_title:Anatomical science international
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-020-00525-3
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073X.2007.00171.x
更新日期:2008-06-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-014-0248-8
更新日期:2015-01-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1046/j.0022-7722.2002.00014.x
更新日期:2002-12-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-019-00483-5
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073X.2006.00119.x
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-012-0133-2
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journal_title:Anatomical science international
pub_type: 杂志文章,评审
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pub_type: 历史文章,杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-015-0296-8
更新日期:2016-06-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-015-0307-9
更新日期:2016-09-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-016-0346-x
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journal_title:Anatomical science international
pub_type: 杂志文章,评审
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journal_title:Anatomical science international
pub_type: 传,历史文章,杂志文章
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更新日期:2016-06-01 00:00:00
abstract::To understand which layer of the intrinsic muscles of the foot the adductor hallucis muscle belongs to, it is essential to investigate the innervation patterns of this muscle. In the present study, we examined the innervation patterns of the adductor hallucis muscles in 17 feet of 15 Japanese cadavers. We investigated...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073x.2006.00143.x
更新日期:2006-09-01 00:00:00
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journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1046/j.0022-7722.2003.00039.x
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