Abstract:
:The gustatory cells in taste buds have been identified as paraneuronal; they possess characteristics of both neuronal and epithelial cells. Like neurons, they form synapses, store and release transmitters, and are capable of generating an action potential. Like epithelial cells, taste cells have a limited life span and are regularly replaced throughout life. However, little is known about the molecular mechanisms that regulate taste cell genesis and differentiation. In the present study, to begin to understand these mechanisms, we investigated the role of Mash1-positive cells in regulating adult taste bud cell differentiation through the loss of Mash1-positive cells using the Cre-loxP system. We found that the cells expressing type III cell markers-aromatic L-amino acid decarboxylase (AADC), carbonic anhydrase 4 (CA4), glutamate decarboxylase 67 (GAD67), neural cell adhesion molecule (NCAM), and synaptosomal-associated protein 25 (SNAP25)-were significantly reduced in the circumvallate taste buds after the administration of tamoxifen. However, gustducin and phospholipase C beta2 (PLC beta2)-markers of type II taste bud cells-were not significantly changed in the circumvallate taste buds after the administration of tamoxifen. These results suggest that Mash1-positive cells could be differentiated to type III cells, not type II cells in the taste buds.
journal_name
Anat Sci Intjournal_title
Anatomical science internationalauthors
Takagi H,Seta Y,Kataoka S,Nakatomi M,Toyono T,Kawamoto Tdoi
10.1007/s12565-018-0431-4subject
Has Abstractpub_date
2018-09-01 00:00:00pages
422-429issue
4eissn
1447-6959issn
1447-073Xpii
10.1007/s12565-018-0431-4journal_volume
93pub_type
杂志文章abstract::Scanning electron microscopy for plastic casts and confocal laser scanning microscopy for Villanueva bone-stained ground sections were used together to observe enamel tubules in red kangaroo molars. Although the tubular structures such as terminals, bends, expansions, splits, divergences and rejoinings in this species...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1046/j.0022-7722.2003.00039.x
更新日期:2003-03-01 00:00:00
abstract::The effects of tamoxifen and soy on apoptosis of the hippocampus and dentate gyrus of ovariectomized rats after repeated seizures were investigated. Female rats were divided into: (1) Control, (2) Sham, (3) Sham-Tamoxifen (Sham-T), (4) Ovariectomized (OVX), (5) OVX-Tamoxifen (OVX-T), (6)OVX-Soy(OVX-S) and (7) OVX-S-T....
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-017-0398-6
更新日期:2018-03-01 00:00:00
abstract::Thiel's embalming method provides natural coloration, flexibility, and tissue plasticity, and is used widely to prepare specimens for cadaver surgical training. However, this method causes brain softening, thereby restricting the cadaver surgical training of intra-cranial procedures. In this study, three cadavers were...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-020-00545-z
更新日期:2020-09-01 00:00:00
abstract::AHNAK has been reported to be involved in actin cytoskeleton rearrangement of some cell types, calcium homeostasis, and activation of T cells. Although the functional role of AHNAK in muscle cells, epidermis, and brain has been determined, its association with apparent clinical impairment has not been found yet. Durin...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-020-00525-3
更新日期:2020-06-01 00:00:00
abstract::The tongue of an adult degu was examined by light and scanning electron microscopy. It consists of an apex, corpus, and radix and contains a lingual prominence. The aim of this study was to describe the course of muscle fascicles of the proper lingual muscle, the presence and nature of the lingual salivary glands, and...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-016-0346-x
更新日期:2017-09-01 00:00:00
abstract::Eukaryotic cells can adapt to endoplasmic reticulum (ER) dysfunction by producing diverse signals from the ER to the cytosol or nucleus. These signaling pathways are collectively known as the unfolded protein response (UPR). The canonical branches of the UPR are mediated by three ER membrane-bound proteins: double-str...
journal_title:Anatomical science international
pub_type: 杂志文章,评审
doi:10.1007/s12565-013-0214-x
更新日期:2014-01-01 00:00:00
abstract::The attachment and innervation of the scalenus muscles in both sides of two Japanese monkeys and a rhesus monkey were observed to discuss their morphological significance while comparing their findings in humans. The scalenus ventralis muscle in macaques had almost the same attachments as the scalenus anterior muscle ...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073x.2004.00063.x
更新日期:2004-03-01 00:00:00
abstract::Although the thoracic duct (TD) requires special attention during thoracic surgery, to our knowledge, its detailed course in the situs inversus totalis (SIT) case has not been reported. We encountered an 86-year-old Japanese female cadaver with SIT during a student anatomical practice and examine the TD. The TD origin...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-020-00532-4
更新日期:2020-06-01 00:00:00
abstract::Rat ascitic-type hepatoma AH7974 cells express CXCR4 mRNA and protein at high levels and also show vigorous migratory responses to its ligand CXCL12. We have shown that AMD3100 (a specific CXCR4 antagonist) effectively reduced tumor invasion into the milky spot in Sprague-Dawley rats inoculated with AH7974 cells. A hi...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-009-0028-z
更新日期:2009-09-01 00:00:00
abstract::The present study was designed and performed on 20 human adult cadavers at the level of the retroperitoneal space in order to provide evidence of the paravertebral and prevertebral sympathetic ganglia. Only one specimen, male, presented two ganglia on the left side located on the first lumbar splanchnic nerve, one pro...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-008-0012-z
更新日期:2009-09-01 00:00:00
abstract::After the authors' previous report an additional case of partial anomalous pulmonary venous return was encountered during dissection practice for medical students. In an 87-year-old Japanese male cadaver, the anomalous vein from the right upper lobe drained into the superior vena cava at a point just below the entranc...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073X.2007.00187.x
更新日期:2008-09-01 00:00:00
abstract::The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical model parameters and evaluate their adequacy. Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-016-0353-y
更新日期:2017-09-01 00:00:00
abstract::We report an adult male cadaver with persistence of the ductus arteriosus and a right retroesophageal artery. The retroesophageal artery was first appreciated as a retropharyngeal mass during the dissection of this area. Both the left and right vertebral arteries originated in normal fashion. The thoracic duct of our ...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1111/j.1447-073x.2004.00068.x
更新日期:2004-06-01 00:00:00
abstract::The northern pike (Esox lucius) is a fresh water species belonging to the Esocidae family. It is a carnivorous fish feeding mostly on invertebrates and fishes. Due to the scantiness of relevant literature regarding the morphology of the tongue in fish we carried out this study with the aim of providing information on ...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-014-0254-x
更新日期:2015-09-01 00:00:00
abstract::The demand for cadavers for clinical skills training is increasing. However, conventional formalin-fixed bodies are often unsuitable for surgical training because the tissues become too hard. We recently developed a new formalin-free embalming method with N-vinyl-2-pyrrolidone (pyrrolidone) that has excellent fixative...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-019-00494-2
更新日期:2020-01-01 00:00:00
abstract::We observed a rare case of the right persistent hypoglossal artery (PHA) in the posterior cranial fossa of a deceased 74-year-old Japanese man who did not have any clinical manifestations related to this anomaly when alive. The large-sized PHA originating from the cervical internal carotid artery passed through the hy...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-009-0062-x
更新日期:2011-03-01 00:00:00
abstract::The hearts of all snakes and lizards consist of two atria and a single incompletely divided ventricle. In general, the squamate ventricle is subdivided into three chambers: cavum arteriosum (left), cavum venosum (medial) and cavum pulmonale (right). Although a similar division also applies to the heart of pythons, thi...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-010-0079-1
更新日期:2010-12-01 00:00:00
abstract::Hepatic biliary injury is one of the most common complications in cholecystectomy and is frequently accompanied by arterial injuries. Because there are several anatomical variations of the hepatic ducts, including the accessory hepatic ducts (AHDs), it is important to consider not only the anatomical position of the h...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-020-00568-6
更新日期:2021-01-01 00:00:00
abstract::For a long time, because of its location at the skull base level, the sphenoid bone was rather mysterious as it was too difficult for anatomists to reach and to elucidate its true configuration. The configuration of the sphenoid bone led to confusion regarding its sutures with the other skull bones, its shape, its det...
journal_title:Anatomical science international
pub_type: 杂志文章,评审
doi:10.1007/s12565-017-0399-5
更新日期:2018-01-01 00:00:00
abstract::Olfactory bulb (OB) interneurons, predominantly periglomerular (PG) and granule (GR) cells, are derived from neural stem cells in the subventricular zone (SVZ) throughout life and migrate to the OB in the rostral migratory stream (RMS). In the adult superficial GR layer transgene expression was found, either enhanced ...
journal_title:Anatomical science international
pub_type: 杂志文章,评审
doi:10.1111/j.1447-073X.2007.00209.x
更新日期:2008-12-01 00:00:00
abstract::The purpose of the study was to discover a way to study the internal structure and evolution of human embryos noninvasively. The human embryo was stained with phosphotungstic acid solution (PTA) in ethanol (EPTA) and scanned using a micro computed tomography (micro-CT) scanner. Using appropriate software, a three-dime...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-016-0377-3
更新日期:2017-03-01 00:00:00
abstract::The arrector pili muscle is a smooth muscle bundle that attaches to the bulge region of the hair follicle and extends to its superior attachment in the upper dermis or epidermis. However, the morphology and origin of the muscle associated with the human mustache is different, having a general smooth arrector pili musc...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-012-0133-2
更新日期:2012-09-01 00:00:00
abstract::The increase in autoimmune diseases in recent years has drawn attention back to the thymus, with new approaches to improve and/or restore immune function being investigated. As the primary lymphoid organ responsible for functional T cell development, studies on the pre-/post-natal development of this organ and T lymph...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-018-0456-8
更新日期:2019-01-01 00:00:00
abstract::We found a five-headed biceps brachii (BB) muscle associated with the pectoralis major muscle in a 43-year-old Korean male cadaver during a routine dissection course. A supernumerary head originated from the anterior surface of the distal tendinous part of the pectoralis major muscle, lay in the sulcus between the sho...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-015-0288-8
更新日期:2016-01-01 00:00:00
abstract::A major component of tooth innervation is made of capsaicin-sensitive primary afferents (CSPA). These fibers play a key role in tooth pain and inflammation; little is known, however, about the role of CSPA in tooth eruption. The aim of this study was to examine the role of the capsaicin-sensitive afferents in the proc...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-018-0460-z
更新日期:2019-01-01 00:00:00
abstract::The demand for anatomical illustrations in the early modern period coincided with a scientific revolution. Starting out as a servant, Iulius Casserius became a great anatomist, who challenged the Galenic doctrine. The aim of this paper is to honor his memory and recreate the stylism of his anatomical illustrations. On...
journal_title:Anatomical science international
pub_type: 传,历史文章,杂志文章
doi:10.1007/s12565-016-0326-1
更新日期:2016-06-01 00:00:00
abstract::Apoptosis of ameloblasts were examined by the TdT-mediated dUTP-biotin nick end-labelling method and electron microscopy 8 h after injection of colchicine. The results showed that extensive apoptosis occurred in ameloblasts of secretion to maturation zones. To determine the possible involvement of stimulators in amelo...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1046/j.0022-7722.2002.00025.x
更新日期:2002-09-01 00:00:00
abstract::Familiarity with the different anatomical variations of the arterial supply of the gallbladder and liver is of great importance in all hepatobiliary surgical procedures. A complex anomaly of the hepatobiliary arterial system, which has never been reported before, was found during anatomical dissection of a 73-year-old...
journal_title:Anatomical science international
pub_type: 杂志文章,评审
doi:10.1007/s12565-013-0219-5
更新日期:2014-06-01 00:00:00
abstract::Sunao Tawara, who was born in 1873 and died in 1952, is considered the father of modern cardiac electrophysiology. He published his monumental monograph describing the atrioventricular conduction axis in 1906. He achieved this task in the face of multiple tribulations as a doctoral student working in a cultural enviro...
journal_title:Anatomical science international
pub_type: 传,历史文章,杂志文章
doi:10.1007/s12565-020-00530-6
更新日期:2020-06-01 00:00:00
abstract::The Reelin (Reln)-deficient mouse (reeler) and the Dab1-deficient mouse (yotari) are autosomal recessive mutant mice characterized by cerebellar ataxia. Previously, we reported that Reelin and Dab1 proteins have slightly different functions during the development of the cerebral cortex. To analyze the functional roles...
journal_title:Anatomical science international
pub_type: 杂志文章
doi:10.1007/s12565-008-0009-7
更新日期:2009-09-01 00:00:00