Abstract:
:Eradication of HIV infection is the most challenging research area in the HIV/AIDS field. Treatment of HIV infection with antiretrovirals halts viral replication but fails to eradicate infection because it does not eliminate latent viruses. Eradication has only been achieved in one exceptional case after bone marrow transplantation. For this reason, researchers were surprised by a report describing the first cure of an HIV-infected individual using antiretrovirals. It was an in utero HIV-infected newborn treated immediately after birth with a potent antiretroviral combination. After treatment interruption, the child showed no evidence for active HIV infection; she was apparently cured. The case is particular and can be seen as an extreme case of postexposure prophylaxis. Moreover, due to strong immunological differences between newborns and adults, the case does not provide new hope for adult HIV-infected individuals, although it may open new treatment standards for functional cure of HIV-infected newborns. However, new studies to proof the benefit of immediate treatment of HIV-exposed newborns will require the definition of point of care diagnostic tools, drug regimens and the minimal time from birth to therapy introduction, and also importantly, when and under what settings should treatment be interrupted to test for functional cure.
journal_name
Expert Opin Pharmacotherjournal_title
Expert opinion on pharmacotherapyauthors
Blanco Jdoi
10.1517/14656566.2013.835396subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2307-9issue
17eissn
1465-6566issn
1744-7666journal_volume
14pub_type
社论abstract:INTRODUCTION:Diabetic foot ulceration is a serious secondary complication of diabetes mellitus and the most common cause of hospitalization in diabetic patients. The etiology of diabetic foot ulcerations is complex due to their multifactorial nature. Thus, addressing all of the factors involved remains instrumental in ...
journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1517/14656566.2011.530658
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abstract:BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk of atherosclerotic cardiovascular disease which cannot be explained by traditional cardiovascular risk factors alone. Atherosclerosis is considered an inflammatory condition and inflammation experienced in RA may contribute to accelerated atheros...
journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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abstract:INTRODUCTION:BRAF inhibition alone has achieved unprecedented efficacy results in patients affected by BRAF-mutated advanced melanoma. Since these findings, it was postulated that dual inhibition of BRAF and other components of the RAS/RAF/MEK/ERK MAPK pathway (such as MEK) would be superior to BRAF inhibition as monot...
journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,随机对照试验
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,评审
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Expert opinion on pharmacotherapy
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doi:10.1517/14656566.7.6.749
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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pub_type: 社论
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journal_title:Expert opinion on pharmacotherapy
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