Advances in pharmacotherapy of vestibular and ocular motor disorders.

abstract：BACKGROUND:This study investigated the safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin (100 mg/day) and low-dose metformin (500 or 750 mg/day). RESEARCH DESIGN AND METHODS:Fifty patients were randomly allocated to the control group (maintaining...

journal_title：Expert opinion on pharmacotherapy

authors： Suzuki L,Kanazawa A,Uzawa H,Osonoi Y,Masuyama A,Azuma K,Takeno K,Takayanagi N,Sato J,Someya Y,Komiya K,Goto H,Mita T,Ikeda F,Ogihara T,Shimizu T,Ohmura C,Saito M,Osonoi T,Watada H

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Glioblastoma, the most common malignant brain tumor, exhibits a poor prognosis with little therapeutic progress in the last decade. Novel treatment strategies beyond the established standard of care with temozolomide-based radiotherapy are urgently needed. AREAS COVERED:We reviewed the literature on gliob...

journal_title：Expert opinion on pharmacotherapy

authors： Seystahl K,Gramatzki D,Roth P,Weller M

更新日期：2016-06-01 00:00:00

abstract：:Introduction: Ventricular arrhythmias are often seen in association with structural heart disease. However, approximately a tenth of affected patients have apparently normal hearts, where such arrhythmias typically occur in young patients, are sometimes inherited and can occasionally lead to sudden cardiac death (SCD)...

journal_title：Expert opinion on pharmacotherapy

authors： Ortmans S,Daval C,Aguilar M,Compagno P,Cadrin-Tourigny J,Dyrda K,Rivard L,Tadros R

更新日期：2019-12-01 00:00:00

abstract：:Itraconazole is a broad spectrum triazole antifungal agent. It has favourable pharmacodynamic and pharmacokinetic profiles and is available as both oral and i.v. formulations. Over the last two decades, clinical and animal infection studies have demonstrated the efficacy of itraconazole in a wide range of superficial ...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Arrese JE,Piérard-Franchimont C

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide. Although advanced NSCLC is still incurable, various anti-neoplastic agents have become available for the treatment of this disease. Pemetrexed , a multi-target folate antagonist, has improved the survival of non-squamous...

journal_title：Expert opinion on pharmacotherapy

authors： Genova C,Rijavec E,Truini A,Coco S,Sini C,Barletta G,Dal Bello MG,Alama A,Savarino G,Pronzato P,Boccardo F,Grossi F

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Parenteral support is lifesaving in short bowel syndrome patients with intestinal failure (SBS-IF), who are unable to compensate for their malabsorption by metabolic or pharmacologic adaptation. Mutually, the symptoms of SBS-IF and the inconveniences and complications in relation to parenteral support may ...

journal_title：Expert opinion on pharmacotherapy

authors： Nørholk LM,Holst JJ,Jeppesen PB

更新日期：2012-02-01 00:00:00

abstract：:Introduction: Insomnia has been implicated in the development, maintenance, worsening, and relapse of alcohol use disorder (AUD).Areas covered: The authors review the possible pharmacological and non-pharmacological treatment options of insomnia for patients with alcohol-use disorder and provide their expert opinion.E...

journal_title：Expert opinion on pharmacotherapy

authors： Geoffroy PA,Lejoyeux M,Rolland B

更新日期：2020-02-01 00:00:00

abstract：:In the recent years, advances in the treatment of chronic hepatitis B and C have shown that newer, more expensive therapy may result in higher sustained viral response rates. In light of this, the pertinent question for healthcare decision-makers centres around whether this increase in efficacy 'justifies' the additio...

journal_title：Expert opinion on pharmacotherapy

authors： Younossi ZM,Temple ME,Shermock KM

更新日期：2001-02-01 00:00:00

abstract：:Despite recent evidence suggesting that Bell's palsy is associated with reactivation of alfa-herpes viruses, the disease has been treated empirically, and the use of valacyclovir has not been definitively established. In 2007, two prospective, randomised, placebo-controlled trials evaluating valacyclovir were reported...

journal_title：Expert opinion on pharmacotherapy

authors： Hato N,Sawai N,Teraoka M,Wakisaka H,Takahashi H,Hinohira Y,Gyo K

更新日期：2008-10-01 00:00:00

abstract：:Therapy of hepatitis C virus (HCV) infection may prevent progression to cirrhosis, hepatocellular carcinoma and end-stage liver disease. The cornerstone of treatment has long been standard IFN-alpha, the use of which was associated with a sustained biochemical and viral response in only a small proportion of patients....

journal_title：Expert opinion on pharmacotherapy

authors： Toniutto P,Fabris C,Pirisi M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:5-Aminolaevulinic acid (ALA) is the naturally occurring metabolic precursor of an endogenously formed photosensitiser, protoporphyrin IX. It is used topically to treat benign and malignant skin disorders by a process called photodynamic therapy (PDT). Recently, data are emerging on its systemic use in the tr...

journal_title：Expert opinion on pharmacotherapy

authors： Dunn J,Lovat L

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Clostridium difficile has become the most important healthcare-associated infection worldwide within the past decade. This is in part due to the emergence of a highly virulent epidemic strain of C. difficile as well as the relative ineffectiveness of current therapies at producing a sustained response. Fid...

journal_title：Expert opinion on pharmacotherapy

authors： Hostler CJ,Chen LF

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Paget's disease of the bone is a common condition in some populations, affecting almost 10% of older adults in western Europe. Though frequently asymptomatic, it can sometimes result in severe disabilities. Timely intervention is now able to arrest disease progression in the majority of patients. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Reid IR

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Breast cancer is a common, life-threatening disease among women. Contemporary hormonal therapy with third-generation aromatase inhibitors for estrogen-receptor-positive breast cancers in postmenopausal women is still facing the challenge of interpatient variability in therapeutic response and intensity of ...

journal_title：Expert opinion on pharmacotherapy

authors： Turkistani A,Marsh S

更新日期：2012-06-01 00:00:00

abstract：:Since the introduction of chlorpromazine in the 1950s, antipsychotics have been used for the treatment of schizophrenia. The phenothiazines were followed by the butyrophenones, particularly haloperidol. With all the movement disorder side effects of these medications (extrapyramidal syndrome, akathisia, tardive dyskin...

journal_title：Expert opinion on pharmacotherapy

authors： Kato MM,Goodnick PJ

更新日期：2001-10-01 00:00:00

abstract：INTRODUCTION:Prostate cancer being the second leading cause of death in men in Western countries remains a major challenge in healthcare. Several novel agents targeting signaling pathways in prostate cancer have recently been approved by the US Food and Drug Administration (FDA) but there is still an unmet need for new...

journal_title：Expert opinion on pharmacotherapy

authors： Deshmukh RR,Schmitt SM,Hwang C,Dou QP

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Treatment of complicated intra-abdominal infections (cIAIs) is becoming increasingly difficult because of the widespread emergence of multidrug-resistant organisms. AREAS COVERED:In this review, we discuss the effectiveness of several new antibiotics for the treatment of cIAIs, including new β-lactamase i...

journal_title：Expert opinion on pharmacotherapy

authors： Lin SY,Huang CH,Ko WC,Chen YH,Hsueh PR

更新日期：2016-01-01 00:00:00

abstract：:HIV infection has a complex relationship with poverty, but affects both the rich and poor. HIV/AIDS represents the deadliest emergency and the greatest social, economic and health crisis of modern times. The HIV pandemic affects developed and developing countries differently, with up to 95% of new HIV infections now o...

journal_title：Expert opinion on pharmacotherapy

authors： Muniyandi M,Ramachandran R,Balasubramanian R

更新日期：2006-12-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) encompass a heterogeneous group of lymphoid malignancies with varying natural histories and prognoses. Recent classifications for NHL have defined distinct lymphoma entities based on morphology, immunophenotype, genetic features, clonal cell lineage and clinical features. These new, more ...

journal_title：Expert opinion on pharmacotherapy

authors： Tan BR,Bartlett NL

更新日期：2000-03-01 00:00:00

abstract：INTRODUCTION:The treatment of classical Hodgkin lymphoma (cHL) in children is a story of success. Nowadays, more than 90% of patients are cured and overall survival is nearly 100% at 5 years. Efforts have been made to avoid related effects of therapies; therefore, children are treated using different chemotherapy schem...

journal_title：Expert opinion on pharmacotherapy

authors： Gómez-Almaguer D,González-Llano O,Jiménez-Antolinez V,Gómez-De León A

更新日期：2019-07-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Inhibition of the aromatase enzyme in postmenopausal women reduces levels of estrogens, which is of therapeutic value in hormone-sensitive breast cancer. Exemestane is a third-generation steroidal irreversible inactivator of the aromatase enzyme used in early and advanced breast cancer for the t...

journal_title：Expert opinion on pharmacotherapy

authors： Bertelli G,Gangadhara S

更新日期：2010-08-01 00:00:00

abstract：:Ovarian cancer is the fifth leading cause of cancer deaths in women. The majority of patients present with advanced disease and relapse after first-line platinum-based chemotherapy; therefore, many proceed to treatment with salvage chemotherapy. Currently available treatment options are generally no longer curative in...

journal_title：Expert opinion on pharmacotherapy

authors： Ahmad T,Gore M

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Diabetic foot ulcers, especially when they become infected, are a leading cause of morbidity and may lead to severe consequences, such as amputation. Optimal treatment of these diabetic foot problems usually requires a multidisciplinary approach, typically including wound debridement, pressure off-loading,...

journal_title：Expert opinion on pharmacotherapy

authors： Abbas M,Uçkay I,Lipsky BA

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Acute promyelocytic leukemia (APL) represents a paradigm of therapeutic success in clinical hematology. Since the introduction of all-trans-retinoic-acid in the early 1980s, complete remission rates exceed 90% and the cure rate is > 70%. Notwithstanding, various questions concerning the manageme...

journal_title：Expert opinion on pharmacotherapy

authors： Ferrara F

更新日期：2010-03-01 00:00:00

abstract：:Accumulating evidence suggests that HIV-infected individuals have an increased risk of cardiovascular events. This risk seems to be at least partially mediated by dyslipidaemia, which is related to the use of highly active antiretroviral therapy (HAART). As HIV-infected individuals live longer due to HAART, their card...

journal_title：Expert opinion on pharmacotherapy

authors： Manuel O,Thiébaut R,Darioli R,Tarr PE

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Breast cancer is the most frequently diagnosed cancer and the highest cause of cancer mortality in females worldwide. The development of drugs improving overall survival in late-stage metastatic breast cancer remains a challenge. Vinflunine is the most recently developed drug in the vinca alkaloid class. I...

journal_title：Expert opinion on pharmacotherapy

authors： Gourmelon C,Bourien H,Augereau P,Patsouris A,Frenel JS,Campone M

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:The global epidemic of diabetes has led to an epidemic of diabetes complications. Diabetic neuropathy is the most common microvascular complication, of which diabetic peripheral neuropathy (DPN) and autonomic neuropathy (AN) are the most prevalent, affecting ~50% of patients. DPN results in pain with a poo...

journal_title：Expert opinion on pharmacotherapy

authors： Azmi S,Alam U,Burgess J,Malik RA

更新日期：2021-01-01 00:00:00

abstract：:ABSTARCT Introduction: Cardiovascular disease (CVD) continues to be an essential cause of morbidity and mortality among people living with human immunodeficiency virus infection (PLWH). Since the bulk of cardiovascular risk (CVR) factors are shared between PLWH and the general population, prevention and treatment stra...

journal_title：Expert opinion on pharmacotherapy

authors： Corbacho N,Mur I,Molas ME,Vidal F,Domingo P

更新日期：2021-01-04 00:00:00

abstract：INTRODUCTION:Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD). The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy. When treating patients with obesity and CVD, certain medications may be more appropriate than others. AREAS COVE...

journal_title：Expert opinion on pharmacotherapy

authors： Andrew CA,Saunders KH,Shukla AP,Aronne LJ

更新日期：2019-04-01 00:00:00

abstract：:In > 80% of patients with autoimmune hepatitis, steroid therapy alone or in combination with azathioprine results in disease remission. Treatment response results in reversal of fibrosis and excellent long-term survival in many patients, whereas untreated patients may expect a 10-year survival of < 30%. The use of aza...

journal_title：Expert opinion on pharmacotherapy

authors： Heneghan MA,Al-Chalabi T,McFarlane IG

更新日期：2006-02-01 00:00:00