Cytotoxic and molecular chemotherapy for high-grade glioma: an emerging strategy for the future.

abstract：INTRODUCTION:Breast cancer (BC) remains the most frequently diagnosed cancer and the most common cause of cancer death among women of all races worldwide. Over 80% of BC cases are hormone receptor (HR)-positive, comprised of luminal A and luminal B per molecular subtypes, imposing an urgent need to fully understand the...

journal_title：Expert opinion on pharmacotherapy

authors： Duso BA,Trapani D,Viale G,Criscitiello C,D'Amico P,Belli C,Mazzarella L,Locatelli M,Minchella I,Curigliano G

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:As type 2 diabetes mellitus (T2DM) advances, patients receiving basal insulin will eventually require another agent on top of their current regimen in order to achieve glycemic control. One such agent that can be administered in combination with basal insulin is the glucagon-like peptide-1 receptor agonist...

journal_title：Expert opinion on pharmacotherapy

authors： Forst T

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Acute decompensated heart failure (ADHF) contributes largely to the burden of heart failure and is associated with a poorer prognosis. Although numerous clinical trials evaluated the benefit of newer medications for ADHF, most of them were not successful. Areas covered: This review focusses on the updates ...

journal_title：Expert opinion on pharmacotherapy

authors： Yandrapalli S,Tariq S,Aronow WS

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:During recent decades, the prognosis of childhood acute lymphoblastic leukemia (ALL) has improved dramatically, nowadays, reaching a cure rate of almost 90%. These results are due to a better management and combination of old therapies, refined risk-group stratification and emergence of minimal residual di...

journal_title：Expert opinion on pharmacotherapy

authors： Santiago R,Vairy S,Sinnett D,Krajinovic M,Bittencourt H

更新日期：2017-08-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) encompass a heterogeneous group of lymphoid malignancies with varying natural histories and prognoses. Recent classifications for NHL have defined distinct lymphoma entities based on morphology, immunophenotype, genetic features, clonal cell lineage and clinical features. These new, more ...

journal_title：Expert opinion on pharmacotherapy

authors： Tan BR,Bartlett NL

更新日期：2000-03-01 00:00:00

abstract：:Introduction: Influenza represents a major public health threat worldwide. Implementation of good personal health and hygiene habits, together with vaccination, is the most effective tools to reduce influenza burden both in community and in healthcare setting. However, achieving adequate vaccination rates is challengi...

journal_title：Expert opinion on pharmacotherapy

authors： Bassetti M,Castaldo N,Carnelutti A

更新日期：2019-10-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension may occur in the context of incomplete lysis of acute pulmonary emboli, resulting in the obstruction of pulmonary blood flow, as well as progressive right ventricular dysfunction and failure. The treatment of choice for this condition is surgical removal of the obstructing...

journal_title：Expert opinion on pharmacotherapy

authors： Hughes R,Jais X,Suntharalingam J,Humbert M,Parent F,Simonneau G,Pepke-Zaba J

更新日期：2006-06-01 00:00:00

abstract：:Antiplatelet therapy is the cornerstone of treatment for patients who present with acute coronary syndrome (ACS) or undergo percutaneous coronary intervention (PCI). Clopidogrel, in combination with aspirin, is associated with improvement in long-term clinical outcomes in these patients and is currently the antiplatel...

journal_title：Expert opinion on pharmacotherapy

authors： Angiolillo DJ,Suryadevara S,Capranzano P,Bass TA

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease. AREAS COVERED:This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on barici...

journal_title：Expert opinion on pharmacotherapy

authors： Mendes JT,Balogh EA,Strowd LC,Feldman SR

更新日期：2020-06-01 00:00:00

abstract：:In > 80% of patients with autoimmune hepatitis, steroid therapy alone or in combination with azathioprine results in disease remission. Treatment response results in reversal of fibrosis and excellent long-term survival in many patients, whereas untreated patients may expect a 10-year survival of < 30%. The use of aza...

journal_title：Expert opinion on pharmacotherapy

authors： Heneghan MA,Al-Chalabi T,McFarlane IG

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Constituting approximately 30% of lymphoid malignancies, diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma in adults worldwide. The clinical and biologic heterogeneity that exists in DLBCL suggests that this entity might actually be comprised of several distinct neoplasms that coul...

journal_title：Expert opinion on pharmacotherapy

authors： Escalón MP,Lossos IS

更新日期：2008-09-01 00:00:00

abstract：:Until recently, atorvastatin was known only as a new but more potent statin ('me too' drug) for lowering low-density lipoprotein cholesterol. In the last 2 years, data has become available on nearly 32,000 patients, in clinical settings ranging from primary prevention to acute coronary syndromes. These trials show the...

journal_title：Expert opinion on pharmacotherapy

authors： Ray KK,Cannon CP

更新日期：2005-06-01 00:00:00

abstract：:Sildenafil revolutionised the treatment of erectile dysfunction (ED) on its introduction in 1998. Not only is it effective, but is, perhaps even more importantly, an extremely acceptable manner in which to treat ED (i.e., oral pharmacotherapy), compared to the other treatments that were available at that time (e.g., i...

journal_title：Expert opinion on pharmacotherapy

authors： Anderson PC,Gommersall L,Hayne D,Arya M,Patel HR

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Seizures or chronic epilepsy are a relatively common occurrence in a neurosurgical setting. However, seizure treatment after neurosurgery has received less attention compared with other causes and only few data are availaible in the literature on management in neurosurgical patients. Areas covered: This pa...

journal_title：Expert opinion on pharmacotherapy

authors： Ambrosi M,Orsini A,Verrotti A,Striano P

更新日期：2017-10-01 00:00:00

abstract：:The prevalence of obesity has noticeably increased worldwide. The clinician is now frequently facing the challenge of managing patients with concomitant chronic obstructive pulmonary disease (COPD) or asthma and obesity. Obesity is often associated with a poorer control of these chronic respiratory diseases and the op...

journal_title：Expert opinion on pharmacotherapy

authors： Lessard A,Maltais F,Boulet LP

更新日期：2008-01-01 00:00:00

abstract：:Gonorrhea remains an important clinical and public health problem throughout the world. Gonococcal infections have historically been diagnosed by Gram stain and culture but are increasingly diagnosed through nucleic acid tests, thereby eliminating the opportunity for antimicrobial susceptibility testing. Gonococcal in...

journal_title：Expert opinion on pharmacotherapy

authors： Barry PM,Klausner JD

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common skin disorder characterized by chronic inflammatory lesions that are frequently vexing for patients and difficult for physicians to treat. Although multiple therapeutic options are available, all have limitations. Topical preparations have issues with patient adherence, as compared to...

journal_title：Expert opinion on pharmacotherapy

authors： Shutty B,West C,Pellerin M,Feldman S

更新日期：2012-08-01 00:00:00

abstract：:Despite the revolutionary introduction of antibiotic therapy in the post-World War II era, primary care physicians continue to struggle with the issue of optimal treatment strategies for bacterial infection and the growing problem of antimicrobial resistance. The aggressive use of potent agents as first-line therapy m...

journal_title：Expert opinion on pharmacotherapy

authors： Nicolau DP

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Silodosin is a new uroselective alpha-blocker with high pharmacological selectivity for the (1A) adrenoceptor. It is an effective and well-tolerated treatment in men with lower urinary tract symptoms (LUTS), due to presumed bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The eff...

journal_title：Expert opinion on pharmacotherapy

authors： Osman NI,Chapple CR,Cruz F,Desgrandchamps F,Llorente C,Montorsi F

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Docetaxel and paclitaxel are among the most active agents for the treatment of breast cancer. These first-generation taxanes are extremely hydrophobic; therefore, solvents are needed for its parenteral administration. Albumin nanoparticle technology allows for the transportation of such hydrophobic drugs w...

journal_title：Expert opinion on pharmacotherapy

authors： Guarneri V,Dieci MV,Conte P

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Bipolar disorder is characterized by mood instability, which can be challenging to manage. First-line pharmacological approaches usually involve lithium, anticonvulsants and antipsychotics. Over the past fifteen years, several second-generation antipsychotics have demonstrated benefits for various phases o...

journal_title：Expert opinion on pharmacotherapy

authors： Janicak PG,Rado JT

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:BRAF inhibition alone has achieved unprecedented efficacy results in patients affected by BRAF-mutated advanced melanoma. Since these findings, it was postulated that dual inhibition of BRAF and other components of the RAS/RAF/MEK/ERK MAPK pathway (such as MEK) would be superior to BRAF inhibition as monot...

journal_title：Expert opinion on pharmacotherapy

authors： Richman J,Martin-Liberal J,Diem S,Larkin J

更新日期：2015-06-01 00:00:00

abstract：:This editorial considers the use of the first selective oral renin inhibitor, aliskiren, in reducing angiotensin (Ang) II reactivation or aldosterone (ALDO) escape during renin-angiotensin-aldosterone system (RAAS) inhibition. RAAS blockade with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin recep...

journal_title：Expert opinion on pharmacotherapy

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Tziomalos K,Karagiannis A

更新日期：2007-04-01 00:00:00

abstract：:Consensus guidelines for the management of HIV infection recommend the use of two nucleoside analogues in combination with either a non-nucleoside reverse transcriptase inhibitor or a ritonavir-boosted protease inhibitor in therapy-naive patients. As adherence is crucial for treatment success, regimens with fewer pill...

journal_title：Expert opinion on pharmacotherapy

authors： Waters L,Moyle G

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Patisiran and inotersen are two therapies approved for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, a rapidly progressive disease with a substantial clinical burden. This analysis indirectly compares the efficacy of patisiran and inotersen on neuropathy and qu...

journal_title：Expert opinion on pharmacotherapy

authors： Gorevic P,Franklin J,Chen J,Sajeev G,Wang JCH,Lin H

更新日期：2021-01-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Flecainide is a class Ic antiarrhythmic agent available in Europe since 1982. The clinical development program of flecainide provided good data on its antiarrhythmic effect for the prevention of ventricular and supraventricular arrhythmias. The Cardiac Arrhythmia Suppression Trial (CAST), conducted to test...

journal_title：Expert opinion on pharmacotherapy

authors： Apostolakis S,Oeff M,Tebbe U,Fabritz L,Breithardt G,Kirchhof P

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. The increasing prevalence of antimicrobial resistance and the limited number of antimicrobial agents in development have necessitated a review of the current status of treatmen...

journal_title：Expert opinion on pharmacotherapy

authors： Choi SH,Koh Y

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Increasing population age, obesity and physical inactivity mean that type 2 diabetes mellitus (T2DM) is increasingly common. Current treatments may be limited by adverse events, drug-drug interactions or contraindication/need for dose adjustment in patients with renal impairment. AREAS COVERED:This paper ...

journal_title：Expert opinion on pharmacotherapy

authors： Forst T,Pfützner A

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Clostridium difficile has become the most important healthcare-associated infection worldwide within the past decade. This is in part due to the emergence of a highly virulent epidemic strain of C. difficile as well as the relative ineffectiveness of current therapies at producing a sustained response. Fid...

journal_title：Expert opinion on pharmacotherapy

authors： Hostler CJ,Chen LF

更新日期：2013-08-01 00:00:00