Abstract：
OBJECTIVES:To study the clinical profile and outcome of childhood tuberculosis treated with Directly Observed Treatment Short (DOTS) course regimen. Also to study the side effects of anti-tubercular treatment (ATT). METHODS:This prospective hospital based observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli. Inclusion criteria were i) All newly diagnosed cases of tuberculosis from 0 to 12 y of age. ii) Children with relapse, treatment failure or defaulters. Exclusion criteria was children with tuberculosis on anti-tubercular treatment (ATT) other than DOTS regimen. A detailed history including demographic profile and clinical examination were carried out for each case. Diagnosis, categorization, treatment (DOTS regimen) and outcome measures were defined according to WHO/RNTCP guidelines. Data was analyzed using SPSS 17. RESULTS:Total number of children enrolled in the study were 93. Mean age was 6 y. Male to female ratio was 0.9:1. Extra pulmonary tuberculosis (EPTB) was common 58 (62.4 %) than pulmonary tuberculosis 35 (37.6 %). The common symptoms/signs were fever (83.8 %), cough (46.2 %), convulsion (17.2 %), loss of appetite (11.8 %) and pallor (75.3 %), lymphadenopathy (18.3 %), hepatomegaly (9.7 %) and splenomegaly (6.5 %). Mantoux test was positive in 59 (63.4 %) children. Acid fast bacilli (AFB) was isolated in 13 (14 %) children in various fluid/histological specimens. The prevalence of HIV infection was 7.5 %. Among 93 children, 88(94.6 %) completed treatment and were declared cured; four children were lost to follow up and one child died. Compliance of DOTS was good and there were no side effects due to ATT. CONCLUSIONS:EPTB was common than pulmonary TB. Efficacy of DOTS in index study was 94.6 %. No adverse effects of ATT were observed.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Panigatti P,Ratageri VH,Shivanand I,Madhu PK,Shepur TAdoi
10.1007/s12098-013-1175-8subject
Has Abstractpub_date
2014-01-01 00:00:00pages
9-14issue
1eissn
0019-5456issn
0973-7693journal_volume
81pub_type
杂志文章abstract：:Low hemoglobin and low MCHC levels were indicative of high incidence of iron deficiency in preschool children. The extent of iron deficiency as assessed by serum ferritin and free erythrocyte protoporphyrin showed a different trend. While FEP levels were highly suggestive of extensive iron deficiency (in 40-45% of chi...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02759985
更新日期：1992-03-01 00:00:00
abstract：:The importance of taurine in diet is poorly understood. The present evidence suggests that it is a conditionally essential aminoacid in man wherein deficiency states may result in adverse changes which will be improved with supplementation. It has a role in fat absorption in preterm infants and children with cystic fi...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02754955
更新日期：1991-05-01 00:00:00
abstract：:This article is our life time experience in conceptualizing and systematically developing Child Development Centre (CDC) Kerala in the last 25 years, from a research project to a national training centre in child and adolescent development and premarital counseling. CDC Kerala's major contribution was in creating a 'c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-016-2071-9
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:The long QT syndrome (LQTS) is a disorder of the electrical system of the heart, due to dysfunction of the ion channels and involving the repolarisation process. The inherited form occurs when there is a mutation in one of the genes which encode the making of a channel. Prolongation of the QT interval renders...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02859375
更新日期：2002-02-01 00:00:00
abstract：:Cerebral Palsy (CP) is the most common chronic disability of childhood. The problems involved are complex; not only do these children have problems of mobility, but a plethora of associated problems [1]. A recent definition of CP includes secondary musculoskeletal problems [2]. The inclusion of this in the definition ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-015-1999-5
更新日期：2016-11-01 00:00:00
abstract：:To study pulmonary function tests (PFT) in multiple transfusion recipient thalassemics, PFTs were done for 30 thalassemics and 20 matched controls. Confirmed cases of thalassemia on regular transfusion therapy were the subject of study. Apart from history and physical examination of the thalassemics, serum ferritin es...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723198
更新日期：2001-03-01 00:00:00
abstract：:Ocular manifestations that occur directly or indirectly as result of a pathologic process that involves other parts of the body, in a pediatric population, will be discussed here. While a myriad number of systemic conditions have ocular manifestations, its importance cannot be undermined because it has implications fo...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2623-2
更新日期：2018-03-01 00:00:00
abstract：:Microscopic polyangiitis (MPA) is a small vessel multisystemic disorder characterised by necrotising small vessel vasculitis without any immune deposits. Kidney and lung are the predominant organs affected in MPA. Skin, gastrointestinal and neurological findings are also described. Isolated pulmonary manifestations ar...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2379-0
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of an MRI-specific play therapy intervention on the need for sedation in young children. METHODS:All children in the age group of 4-10 y, who were advised an MRI scan over a period of one year were randomized. Exclusion criteria included children with neurodevelopmental disorder...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12098-015-1917-x
更新日期：2016-03-01 00:00:00
abstract：:Harlequin fetus is the severe form of congenital ichthyosis. There are very few reports of babies with this condition surviving the first few weeks of life. We treated two siblings who lived for 22 months and six weeks respectively. We started treatment with oral etretinate every early in their lives and achieved good...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02752311
更新日期：1998-03-01 00:00:00
abstract：:Secondary sex characteristics were evaluated in thalassemic children (41, boys and 30 girls), who were on regular transfusion therapy and were above 11 years of age. The results of this study indicate that the development of secondary sex characteristics in thalassemic children is markedly delayed as compared to their...
journal_title：Indian journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/BF02725511
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:Zinc deficiency is very common in developing countries and is more pronounced during an episode of diarrhea. Supplementation with zinc improves diarrhea and might correct zinc deficiency in both the short and longer term. METHOD:We conducted a nested study within a cluster randomized treatment trial. Fifty c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02759893
更新日期：2006-06-01 00:00:00
abstract：:Multidrug-resistant tuberculosis (MDR TB) has become a major global health concern and is also an issue in children. Children with MDR TB need longer duration of treatment with multiple drugs. The MDR TB treatment regimen usually comprises of a fluoroquinolone, an aminoglycoside, ethionamide, cycloserine, pyrazinamide...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-019-02923-6
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low dose vasopressin on the hemodynamics of neonates with persistent pulmonary hypertension and catecholamine refractory shock. METHODS:This retrospective study was conducted in a level III NICU of a tertiary care teaching hospital, south India. Eighteen neonates with hypoxemic resp...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03519-1
更新日期：2020-10-08 00:00:00
abstract：OBJECTIVES:To identify risk factors and outcomes associated with early failure of nasal continuous positive airway pressure (CPAP) in premature infants with respiratory distress (RD). METHODS:This is a retrospective observational study of all the preterm infants with RD primarily supported on nasal CPAP and included i...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03399-5
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:To prospectively study the clinical and developmental profile; hematological profile and the B-12 status using multiple parameters in children with Infantile tremor syndrome (ITS). METHODS:In this observational study (NCT02762682) (July 2015 through December 2016) children (and their mothers) with a clinica...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03117-w
更新日期：2020-03-01 00:00:00
abstract：:High vaginal swabs (HVS) of 1792 expectant mothers were sent for culture at the time of delivery, prior to first vaginal examination. The newborns were followed-up for development of superficial or deep infections. Appropriate cultures of the babies who developed infections were sent. Bacterial growth of predominantly...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02820186
更新日期：1991-09-01 00:00:00
abstract：:India currently has an infant mortality rate (IMR) of 73 and aims to reach 60 per 1000 live births by 2000 A.D. The "at risk" approach which has been traditionally used for Maternal and Child Health services could help to reduce costs. The main objective of the study was to identity socio-demographic "risk factors" at...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02859456
更新日期：2000-06-01 00:00:00
abstract：:A 5-year-old child presented with the second episode of meningitis when we started investigating her to find a cause for recurrent episode of meningitis. During this she suffered from a third attack after which she was diagnosed as having isolated C(3) deficiency. She was put on penicillin prophylaxis and vaccinated a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0036-y
更新日期：2009-01-01 00:00:00
abstract：:Hypocalcemia is a rare, but reversible, cause of congestive heart failure. We report a 4-month-old boy diagnosed as dilated cardiomyopathy who had prolonged QoTc with low blood levels of calcium, normal phosphate, elevated alkaline phosphatase and findings suggestive of rickets. In view of non response to calcium and ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723209
更新日期：2001-03-01 00:00:00
abstract：:The authors report a case of intra-abdominal migration of a Kirschner wire from the left hip to the right lobe of the liver in a 5-year-old child. The wire was used for stabilization of the left hip after open reduction for neglected unreduced congenital dislocation of the left hip. The migrated wire was removed by la...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02763056
更新日期：2006-12-01 00:00:00
abstract：:Sore throat is one of the common reasons for outpatient and emergency visits among children. It could be because of several etiologies; of these bacterial pharyngitis is the most important. Major challenge for the clinician is to diagnose group A beta hemolytic streptococcus (GABHS) pharyngitis and diphtheria, which a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-011-0467-0
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:To describe the clinico-bacteriological profile, and early outcomes of infants diagnosed with Group B streptococcus (GBS) meningitis. METHODS:This was a retrospective review of infants (aged 1 mo to 2 y) diagnosed with GBS meningitis in a tertiary care hospital in New Delhi from October 2010 through January...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1157-x
更新日期：2014-01-01 00:00:00
abstract：:Allan-Herndon-Dudley Syndrome (AHDS) is a rare X-linked disorder caused by mutation in the gene encoding the monocarboxylate transporter-8. Abnormal transport function is reflected by elevated free T3 and decreased free T4 levels along with clinical features characterized by neurological abnormalities including global...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To find out whether gDNA methylation can be used as a diagnostic/prognostic method for neonatal sepsis. METHODS:The study was conducted in the neonatal division of a tertiary care referral hospital. Fifty one newborns as cases and thirty seven newborns as controls were enrolled in the study. Using 5-mC DNA E...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1574-5
更新日期：2015-04-01 00:00:00
abstract：:A 3-yr-old boy presented with respiratory distress of 2 days duration. There was a history of blunt trauma to the lower chest having occurred 5 days earlier. Although missed initially, serial chest X-rays and a computed tomographic (CT) scan revealed an isolated traumatic right-sided diaphragmatic hernia without any i...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0282-z
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from Decem...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03032-0
更新日期：2019-12-01 00:00:00
abstract：:The authors present 2 cases of dengue shock syndrome with unusual complications. In the first case, a 14-y-old boy with dengue shock syndrome who required aggressive fluid resuscitation, developed abdominal compartment syndrome (ACS). Patient developed severe shock, increased ventilator requirement and oliguria as a c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0551-5
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To predict neuromotor outcome in Very Low Birth Weight infants at 1 year using Movement Assessment of Infants scale at 4 and 8 months of corrected age. METHODS:This hospital based prospective observational study consecutively recruited 45 infants with birth weight ≤ 1,500 g and admitted to neonatal intensive...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0468-z
更新日期：2011-11-01 00:00:00
abstract：:Thirty patients below the age of 15 years (range 8-1/2 to 15 years, mean 11.8 years) have been studied for the severity of rheumatic mitral regurgitation. Moderately severe to severe pulmonary venous hypertension was found in 76.6% and pulmonary arterial hypertension in 60%. Left ventricular volumes could be calculate...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02832994
更新日期：1992-09-01 00:00:00
