Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases.

Abstract:

BACKGROUND:The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic of Congo (DRC). Despite the high prevalence of this disease in our midst, there has been no report on the clinical features in the sickle cell pediatric population suffering from malaria in our midst. METHODS:A retrospective survey of records from the Department of Paediatrics of the University Hospital of Kinshasa, Kinshasa, Democratic Republic of Congo, was done for the period 1998–2008. For the 10 years studied, 108 children with SCD were reviewed and the data of those who developed malaria during admission were retrieved and analyzed. RESULTS:Of the 90 homozygous sickle cell children with malaria, fever, pallor, and jaundice were the commonly-found symptoms. Lethargy, severe anemia, respiratory distress, splenomegaly, hepatomegaly,digestive disorders, and prostration were common in children under 5 years, with significant difference (P, 0.05) to the older children. Transfusion because of to severe anemia was found necessary in 54.4% of cases. No case of cerebral malaria was found. Blackwater fever was a rare event. Hand–foot syndrome was present in 12.8% of patients, exclusively in those less than 5 years old. Pain crisis was associated in 46 cases (51.1%). Pain crisis was particularly present in SCD children less than 5 years of age (74.5% vs 25.6%, P , 0.001). No death was observed in this series. CONCLUSION:We conclude that the acute crisis related to SCD is more common in children less than 5 years of age. High risk of a requirement for blood transfusion was found in young children. Anti-malarial prophylaxis is advocated in Kinshasa.

journal_name

Pathog Glob Health

authors

Aloni MN,Tshimanga BK,Ekulu PM,Ehungu JL,Ngiyulu RM

doi

10.1179/2047773213Y.0000000089

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

198-201

issue

4

eissn

2047-7724

issn

2047-7732

pii

pgh127

journal_volume

107

pub_type

杂志文章
  • Can Plasmodium's tricks for enhancing its transmission be turned against the parasite? New hopes for vector control.

    abstract::Approximately 120 years ago the link between mosquito and the malaria transmission was discovered. However, even today it remains an open question whether the parasite is able to direct the blood-seeking and feeding behavior of its mosquito vector to maximize the probability of transmission. If the parasite has this a...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1080/20477724.2019.1703398

    authors: Emami SN,Hajkazemian M,Mozūraitis R

    更新日期:2019-12-01 00:00:00

  • Frequency, diagnostic performance of coproantigen detection and genotyping of the Giardia among patients referred to a multi-level teaching hospital in northern India.

    abstract::Giardiasis, a common gastrointestinal parasitic infection in tropics, is diagnosed on stool microscopy (gold standard); however, its sensitivity is low due to intermittent fecal shedding. Coproantigen detection (ELISA) is useful but requires further evaluation. We aimed to study: (a) detection of Giardia by stool micr...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2016.1254141

    authors: Ghoshal U,Shukla R,Pant P,Ghoshal UC

    更新日期:2016-01-01 00:00:00

  • Do we need a vaccine against chikungunya?

    abstract::During the last decade, the chikungunya (CHIKV) virus has expanded its range of activity, conquering new territories and becoming an important global health threat. In particular, the challenge represented by the recent emergence of CHIKV in the Americas has strengthened the need of a safe and effective vaccine. Altho...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1179/2047773215Y.0000000017

    authors: Rezza G

    更新日期:2015-06-01 00:00:00

  • Neonatal liver abscesses due to Candida infection in a preterm infant, secondary to malpositioned umbilical lines--a rare entity.

    abstract::Neonatal liver abscess is an uncommon seen condition in neonatology and it holds a very high neonatal mortality because of difficulty in diagnosis and treatment. Till today, only few instances are reported that too are mainly in preterm. Its diagnosis requires a high index of suspicion. Fungal hepatic abscess is very ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1179/2047773215Y.0000000008

    authors: Sharma D,Choudhary M,Shastri S,Sharma PK

    更新日期:2015-03-01 00:00:00

  • Community mobilization and household level waste management for dengue vector control in Gampaha district of Sri Lanka; an intervention study.

    abstract:INTRODUCTION:Waste management through community mobilization to reduce breeding places at household level could be an effective and sustainable dengue vector control strategy in areas where vector breeding takes place in small discarded water containers. The objective of this study was to assess the validity of this a...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/2047773212Y.0000000060

    authors: Abeyewickreme W,Wickremasinghe AR,Karunatilake K,Sommerfeld J,Axel K

    更新日期:2012-12-01 00:00:00

  • Genetic diversity of Trichomonas vaginalis clinical isolates from Henan province in central China.

    abstract::Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China. Fragments of the small subunit of nuclear ribosomal RNA...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773215Y.0000000020

    authors: Mao M,Liu HL

    更新日期:2015-07-01 00:00:00

  • Care-seeking behaviour and diagnostic processes for symptomatic giardiasis in children attending an academic paediatric hospital.

    abstract::Giardiasis is one of the commonest intestinal parasitic infections in Cuba. In order to determine care-seeking behaviour and diagnostic processes in paediatric in-patients with giardiasis, structured questionnaires were administered by interview mothers of children with giardiasis during January to December 2010. Duri...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773214Y.0000000152

    authors: Escobedo AA,Almirall P,Ávila I,Salazar Y,Alfonso M

    更新日期:2014-09-01 00:00:00

  • Clinical and molecular monitoring of Plasmodium falciparum resistance to antimalarial drug (artesunate+sulphadoxine-pyrimethamine) in two highly malarious district of Madhya Pradesh, Central India from 2012-2014.

    abstract::The spread of P. falciparum resistant strain has led to a significant resurgence of malaria morbidity and mortality. The current cornerstone in malaria treatment in India is Artemisinin based Combination (Artesunate + Sulphadoxine-Pyrimethamine) Therapy (ACT) for treatment of uncomplicated P. falciparum malaria since ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2017.1331875

    authors: Mishra S,Bharti PK,Shukla MM,Ali NA,Kashyotia SS,Kumar A,Dhariwal AC,Singh N

    更新日期:2017-06-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus: epidemiology and antimicrobial susceptibility experiences from the University Hospital 'Luigi Vanvitelli' of Naples.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is one of the important pathogens worldwide showing resistance to several widely used antibiotics. This has made the treatment of MRSA infections harder, especially due to their prevalence in the hospital setting. We evaluated the antibiotic susceptibility patterns of...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2020.1827197

    authors: Pignataro D,Foglia F,Della Rocca MT,Melardo C,Santella B,Folliero V,Shinde S,Pafundi PC,Sasso FC,Iovene MR,Galdiero M,Boccia G,Franci G,Finamore E,Galdiero M

    更新日期:2020-12-01 00:00:00

  • Comparison of phenotypic and virulence genes characteristics in human and chicken isolates of Proteus mirabilis.

    abstract::The objective of this work is to compare the phenotypic and virulence genes characteristics in human and chicken isolates of Proteus mirabilis. The bacterial examination of 50 livers of individual broilers, marketed by four major outlets, revealed a high recovery of P. mirabilis (66%), and a low recovery frequency of ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773212Y.0000000042

    authors: Barbour EK,Hajj ZG,Hamadeh S,Shaib HA,Farran MT,Araj G,Faroon O,Barbour KE,Jirjis F,Azhar E,Kumosani T,Harakeh S

    更新日期:2012-10-01 00:00:00

  • Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax.

    abstract::We report a case of facultative intestinal myiasis due to larvae of the drone fly Eristalis tenax, also named the rat-tailed maggots. The development of larvae in the lower bowel was responsible for non-specific gastrointestinal symptoms that resembled ulcerative proctitis. The diagnosis was established upon the obser...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773214Y.0000000135

    authors: Desoubeaux G,Gaillard J,Borée-Moreau D,Bailly É,Andres CR,Chandenier J

    更新日期:2014-04-01 00:00:00

  • HIV P24 antigen among HIV antibody seronegative blood donors in Osogbo Osun State, South Western Nigeria.

    abstract:BACKGROUND:Efforts to curb the spread of HIV transmission through transfusion of blood and its products is still a problem because of challenge in countries using antibody-based rapid methods to detect infection during window period. Transmission of HIV through infected blood and its products accounts for approximately...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2016.1205311

    authors: Olowe OA,Mabayoje VO,Akanbi O,Adefioye OJ,Olowe RA,Fadeni EK,Oluremi AS,Opaleye OO

    更新日期:2016-06-01 00:00:00

  • Identification of previously untypable RD cell line isolates and detection of EV-A71 genotype C1 in a child with AFP in Nigeria.

    abstract::We previously attempted to identify 96 nonpolio enteroviruses (EVs) recovered in RD cell culture from children <15 years with acute flaccid paralysis in Nigeria. We succeeded in identifying 69 of the isolates. Here, we describe an attempt to identify the remaining 27 isolates. Twenty-six (the 27th isolate was exhauste...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2018.1548117

    authors: Adewumi OM,Faleye TOC,Okeowo CO,Oladapo AM,Oyathelemhi J,Olaniyi OA,Isola OC,Adeniji JA

    更新日期:2018-12-01 00:00:00

  • Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.

    abstract::Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P < 0·01), IL-6 (P < 0·01), and IL-10 (P < 0·05) compared to t...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773212Y.0000000069

    authors: Perera MK,Herath NP,Pathirana SL,Phone-Kyaw M,Alles HK,Mendis KN,Premawansa S,Handunnetti SM

    更新日期:2013-01-01 00:00:00

  • Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan.

    abstract::Acanthamoeba keratitis is a painful and progressive infection of the cornea that can result in loss of vision. Here, for the first time in Pakistan, we report two cases of Acanthamoeba keratitis. The first patient was a 37-year-old female who presented with severe itching, redness, pain, along with loss of vision. The...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773213Y.0000000124

    authors: Siddiqui R,Chaudhry T,Lakhundi S,Ahmad K,Khan NA

    更新日期:2014-01-01 00:00:00

  • Factors associated with parasitic infection amongst street children in orphanages across Lima, Peru.

    abstract::Infection caused by intestinal parasites has significant public health consequences amongst children in the developing world. Street children are an under-studied group of society subjected to increased health risks when compared to their peers. To estimate the prevalence of intestinal parasitic infection and ascertai...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773213Y.0000000073

    authors: Bailey C,Lopez S,Camero A,Taiquiri C,Arhuay Y,Moore DA

    更新日期:2013-03-01 00:00:00

  • Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management.

    abstract::Neurocysticercosis has been recognized as a major cause of secondary epilepsy worldwide. So far, most of the knowledge about the disease comes from Latin America and the Indian subcontinent. Unfortunately, in sub-Saharan Africa the condition was neglected for a long time, mainly owing to the lack of appropriate diagn...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1179/2047773212Y.0000000047

    authors: Winkler AS

    更新日期:2012-09-01 00:00:00

  • Prevalence and risk factors of brucellosis among veterinary health care professionals.

    abstract::The study describes prevalence, clinical symptoms and risk factors for brucellosis in personnel engaged in veterinary health care in Karnataka, India. A total of 1050 sera samples were collected from animal handlers, veterinarians, veterinary students, para-veterinarians and persons engaged in artificial insemination ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2017.1345366

    authors: Shome R,Kalleshamurthy T,Shankaranarayana PB,Giribattanvar P,Chandrashekar N,Mohandoss N,Shome BR,Kumar A,Barbuddhe SB,Rahman H

    更新日期:2017-07-01 00:00:00

  • Zika virus infection and pregnancy: what we do and do not know.

    abstract::Recent data strongly suggest an association between the current outbreak of ZIKA virus (ZIKV) in many countries of Central and South America and a sharp increase in the detection of microcephaly and fetal malformations. The link with brain defect, which has been detected mainly in some areas of Brazil, is supported by...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1080/20477724.2016.1234804

    authors: Ticconi C,Pietropolli A,Rezza G

    更新日期:2016-01-01 00:00:00

  • Malaria in a tertiary health care facility of Central India with special reference to severe vivax: implications for malaria control.

    abstract::Plasmodium vivax is now recognized as a cause of severe and fatal infection in many parts of the world. This prospective observational study was undertaken in a tertiary health setting to understand the spectrum of the disease burden and associated complications due to P. vivax malaria in central India. A malaria clin...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/204777213X13777615588180

    authors: Jain V,Agrawal A,Singh N

    更新日期:2013-09-01 00:00:00

  • wsp-based analysis of Wolbachia strains associated with Phlebotomus papatasi and P. sergenti (Diptera: Psychodidae) main cutaneous leishmaniasis vectors, introduction of a new subgroup wSerg.

    abstract::Sand flies of Phlebotomus papatasi and P. sergenti are the main vectors of cutaneous leishmanisis (CL) in the old world. We aimed to screen Iranian P. papatasi and P. sergenti for their natural infections with Wolbachia and to determine their phylogenetic association with other species. Wolbachia surface protein (wsp)...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2018.1471438

    authors: Karimian F,Vatandoost H,Rassi Y,Maleki-Ravasan N,Choubdar N,Koosha M,Arzamani K,Moradi-Asl E,Veysi A,Alipour H,Shirani M,Oshaghi MA

    更新日期:2018-05-01 00:00:00

  • Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012-2013 outcomes.

    abstract:BACKGROUND:We aimed to identify challenges and to propose solutions for the implementation of tuberculosis (TB) programmes in rural Sub-Saharan Africa (SSA) by evaluating the outcomes of the TB programme in the Ancuabe district in rural Northern Mozambique. METHODS:Retrospective descriptive study of the patients inclu...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773215Y.0000000027

    authors: Wikman-Jorgensen PE,Morales-Cartagena A,Llenas-García J,Pérez-Porcuna TM,Hobbins M,Ehmer J,Mussa MA,Abellana R,Ascaso C

    更新日期:2015-07-01 00:00:00

  • Humans parasitized by the hard tick Ixodes ricinus are seropositive to Midichloria mitochondrii: is Midichloria a novel pathogen, or just a marker of tick bite?

    abstract::Midichloria mitochondrii is an intracellular bacterium found in the hard tick Ixodes ricinus. In this arthropod, M. mitochondrii is observed in the oocytes and in other cells of the ovary, where the symbiont is present in the cell cytoplasm and inside the mitochondria. No studies have so far investigated whether M. m...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773212Y.0000000050

    authors: Mariconti M,Epis S,Gaibani P,Dalla Valle C,Sassera D,Tomao P,Fabbi M,Castelli F,Marone P,Sambri V,Bazzocchi C,Bandi C

    更新日期:2012-11-01 00:00:00

  • Epidemiological and clinical profile of immunosuppressed patients with imported strongyloidiasis: a substudy from a larger cohort of the +REDIVI Spanish Collaborative Network.

    abstract::The aim of this study was to describe the clinical and epidemiological profile of immunosuppressed patients with imported strongyloidiasis in a non-endemic setting, and to compare these results with non-immunosuppressed patients. This is a case-control substudy from a larger observational retrospective study that incl...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2020.1857491

    authors: Salvador F,Treviño B,Chamorro-Tojeiro S,Pou D,Herrero-Martínez JM,Rodríguez-Guardado A,Oliveira-Souto I,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Bosch-Nicolau P,Aznar ML,López-Vélez R,Pérez-Molina JA

    更新日期:2020-12-30 00:00:00

  • Discovery and characterization of two Nimrod superfamily members in Anopheles gambiae.

    abstract::Anti-bacterial proteins in mosquitoes are known to play an important modulatory role on immune responses to infections with human pathogens including malaria parasites. In this study we characterized two members of the Anopheles gambiae Nimrod superfamily, namely AgNimB2 and AgEater. We confirm that current annotation...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/204777213X13867543472674

    authors: Midega J,Blight J,Lombardo F,Povelones M,Kafatos F,Christophides GK

    更新日期:2013-12-01 00:00:00

  • Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline.

    abstract::Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae by exploiting the meiotic activity of the I-PpoI endonuclease targetin...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2020.1803628

    authors: Haghighat-Khah RE,Sharma A,Wunderlich MR,Morselli G,Marston LA,Bamikole C,Hall A,Kranjc N,Taxiarchi C,Sharakhov I,Galizi R

    更新日期:2020-10-01 00:00:00

  • Evaluation of Syrian refugees' emergency service admissions in the western region of Turkey.

    abstract::Immigration increases physical, mental, and social health problems. Emergency departments constitute resources that refugees can easily access and where they frequently present. Physicians from every specialty (chest diseases, thoracic surgery, internal diseases, etc.) may be consulted if needed. We aimed to compare d...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1080/20477724.2021.1878442

    authors: Kaya H,Sengoren Dikis O,Sezgin B,Demirci H,Haberal MA,Akar E,Yüksel M

    更新日期:2021-01-24 00:00:00

  • The important role of early diagnosis and preventive management during a large-scale outbreak of hepatitis A in Thailand.

    abstract:INTRODUCTION:Acute hepatitis A is a worldwide public health problem especially in developing countries. Recently, a large, community-wide outbreak of hepatitis A occurred in the northeast part of Thailand. METHODS:Demographic and clinical data as well as blood samples were collected and analyzed from patients with acu...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773213Y.0000000116

    authors: Poovorawan K,Chattakul P,Chattakul S,Thongmee T,Theamboonlers A,Komolmit P,Poovorawan Y

    更新日期:2013-10-01 00:00:00

  • Implication of vector characteristics of Phlebotomus argentipes in the kala-azar elimination programme in the Indian sub-continent.

    abstract:BACKGROUND:Visceral leishmaniasis (VL), also known as kala-azar in the Indian sub-continent (ISC), is a major public health concern in Bangladesh, India, and Nepal, where it is caused by Leishmania donovani transmitted by the sand fly Phlebotomus argentipes. Various ecological parameters including air temperature, rain...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审

    doi:10.1080/20477724.2016.1180775

    authors: Chowdhury R,Kumar V,Mondal D,Das ML,Das P,Dash AP,Kroeger A

    更新日期:2016-05-01 00:00:00

  • Cystic echinococcosis in Mundari tribe-members of South Sudan.

    abstract::Many neglected tropical diseases, including the zoonotic disease cystic echinococcosis (hydatidosis), are endemic to East Africa. However, their geographical distribution is heterogenous and incompletely characterized. The aim of this study was to determine if Mundari pastoralists harbor endemic human hydatidosis. The...

    journal_title:Pathogens and global health

    pub_type: 杂志文章

    doi:10.1179/2047773213Y.0000000111

    authors: Stewart BT,Jacob J,Finn T,Lado M,Napoleon R,Brooker S,Sidhu PS,Kolaczinski J

    更新日期:2013-09-01 00:00:00