Effects of highly overdosed indomethacin in a preterm infant with symptomatic patent ductus arteriosus.

Abstract:

:We describe a preterm infant with severe idiopathic respiratory distress syndrome (iRDS, hyaline membrane disease) who needed artificial ventilation with high inspiratory pressure, high frequencies, 100% oxygen and developed a symptomatic patent ductus arteriosus (sPDA) in the course of the disease. The infant was given indomethacin to induce constriction of sPDA. Due to an error in drug dilution the patient received a 100-fold overdose of indomethacin. Compared to the normal study protocol side-effects such as renal failure were not observed probably due to sufficient fluid intake and good clinical condition prior to treatment and to the rapid and persistent ductal closure.

journal_name

Eur J Pediatr

authors

Schuster V,von Stockhausen HB,Seyberth HW

doi

10.1007/BF02034756

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

651-3

issue

9

eissn

0340-6199

issn

1432-1076

journal_volume

149

pub_type

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