The SPLIT research agenda 2013.

Abstract:

:This review focuses on active clinical research in pediatric liver transplantation with special emphasis on areas that could benefit from studies utilizing the SPLIT infrastructure and data repository. Ideas were solicited by members of the SPLIT Research Committee and sections were drafted by members of the committee with expertise in those given areas. This review is intended to highlight priorities for clinical research that could successfully be conducted through the SPLIT collaborative and would have significant impact in pediatric liver transplantation.

journal_name

Pediatr Transplant

authors

Alonso EM,Ng VL,Anand R,Anderson CD,Ekong UD,Fredericks EM,Furuya KN,Gupta NA,Lerret SM,Sundaram S,Tiao G,Studies of Pediatric Liver Transplantation (SPLIT) Research Group.

doi

10.1111/petr.12090

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

412-22

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

17

pub_type

杂志文章,评审
  • Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients.

    abstract::The clinical utility of tacrolimus monitoring in adults has been well documented. The present study compared tacrolimus monitoring in a pediatric population of 34 liver transplant patients in four US centers with an adult population of 111 patients in six US centers. Subjects (adult and pediatric) were evaluated, at d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2000.00000.x

    authors: MacFarlane GD,Venkataramanan R,McDiarmid SV,Pirsch JD,Scheller DG,Ersfeld DL,Fitzsimmons WE

    更新日期:2001-04-01 00:00:00

  • Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation.

    abstract::Comparisons of perceived barriers to adherence in pediatric and adolescent SOT have not been systematically conducted despite association between medication non-adherence and poor outcome. Fifteen centers in CTOT-C enrolled patients in a cross-sectional study. Subjects' guardians completed the PMBS and subjects over e...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12648

    authors: Danziger-Isakov L,Frazier TW,Worley S,Williams N,Shellmer D,Dharnidharka VR,Gupta NA,Ikle D,Sweet SC,CTOTC-05 Consortium.

    更新日期:2016-03-01 00:00:00

  • Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry "MYKKE".

    abstract::Myocarditis represents an important cause for acute heart failure. MYKKE, a prospective multicenter registry of pediatric patients with myocarditis, aims to gain knowledge on courses, diagnostics, and therapy of pediatric myocarditis. The role of mechanical circulatory support (MCS) in children with severe heart failu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/petr.13548

    authors: Schubert S,Opgen-Rhein B,Boehne M,Weigelt A,Wagner R,Müller G,Rentzsch A,Zu Knyphausen E,Fischer M,Papakostas K,Wiegand G,Ruf B,Hannes T,Reineker K,Kiski D,Khalil M,Steinmetz M,Fischer G,Pickardt T,Klingel K,Messr

    更新日期:2019-11-01 00:00:00

  • Lower socioeconomic status is associated with worse outcomes after both listing and transplanting children with heart failure.

    abstract::The relationship between SES and outcomes surrounding pediatric cardiac transplantation is complex and influenced by recipient race. Broad-based studies of SES have not been performed. A retrospective review of all 5125 primary pediatric heart transplants performed in the United States between 2000 and 2011. Patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12117

    authors: Davies RR,Russo MJ,Reinhartz O,Maeda K,Rosenthal DN,Chin C,Bernstein D,Mallidi HR

    更新日期:2013-09-01 00:00:00

  • Current approaches to treatment of antibody-mediated rejection.

    abstract::Antibody-mediated rejection (AMR) has recently been recognized as a significant and unique form of rejection that is not amenable to treatment with standard immunosuppressive medications aimed at modification of T-cell function. Recent interest in AMR and the role of B cells in rejection has been aided by the concomit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00363.x

    authors: Jordan SC,Vo AA,Tyan D,Nast CC,Toyoda M

    更新日期:2005-06-01 00:00:00

  • Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study.

    abstract::The development of malignancy in a renal transplant graft is an uncommon phenomenon. A renal neoplasm developing in the adult donor kidney of a pediatric transplant recipient has only rarely been reported. We report a case of collecting duct carcinoma arising in association with BK virus nephropathy in an adult living...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00855.x

    authors: Emerson LL,Carney HM,Layfield LJ,Sherbotie JR

    更新日期:2008-08-01 00:00:00

  • Fulminant recurrence of atypical hemolytic uremic syndrome during a calcineurin inhibitor-free immunosuppression regimen.

    abstract::Recurrence of hemolytic uremic syndrome (HUS) after kidney transplantation is frequent, occurring almost exclusively in patients with atypical HUS, which is not caused by Escherichia coli gastroenteritis and in which diarrhea is absent. Calcineurin inhibitors are associated with recurrence of HUS. In two children who ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-1-00002.x

    authors: Florman S,Benchimol C,Lieberman K,Burrows L,Bromberg JS

    更新日期:2002-08-01 00:00:00

  • A typology of non-adherence in pediatric renal transplant recipients.

    abstract::We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00117.x

    authors: Shaw RJ,Palmer L,Blasey C,Sarwal M

    更新日期:2003-12-01 00:00:00

  • Transplanting patients with a positive donor-specific crossmatch: a single center's perspective.

    abstract::An increasing number of individuals with end-stage renal disease have become sensitized to human leukocyte antigens (HLA). Sensitization can have a profound impact on the likelihood of obtaining a requisite negative crossmatch (-XM) with a potential donor. Technologic breakthroughs in our ability to diagnose antibody-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00214.x

    authors: Montgomery RA,Zachary AA

    更新日期:2004-12-01 00:00:00

  • Cognitive abilities, behaviour and quality of life in children after liver transplantation.

    abstract:AIMS:We investigated interrelations between cognitive abilities, behavioural problems, quality of life and disease-related variables of children after LTX. METHODS:Our sample consisted of 25 children. They were 8.5/2.8 (M/SD) years old and had received the transplant 5.5/3.1 years previously. For assessment we used we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01257.x

    authors: Kaller T,Boeck A,Sander K,Richterich A,Burdelski M,Ganschow R,Schulz KH

    更新日期:2010-06-01 00:00:00

  • National risk factors and estimated costs for redo ureteroneocystostomy after pediatric renal transplant.

    abstract::Approximately 800 pediatric renal transplants are performed annually in the United States. VUR or obstruction may cause graft failure requiring redo ureteroneocystostomy. We examined possible risk factors and cost using the PHIS national database. We examined the PHIS for 8.5 yr to determine the association between re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12522

    authors: Godebu E,Palazzi K,Bush R,Marietti S,Chiang G

    更新日期:2015-08-01 00:00:00

  • Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

    abstract::In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left latera...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13384

    authors: Ocwieja KE,Vargas SO,Elisofon SA,Shulman DS,Lee CK,Fawaz R,Collins N,Vakili K,Sharma TS

    更新日期:2019-05-01 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00

  • Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.

    abstract::Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Dat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12914

    authors: Habbig S,Volland R,Krupka K,Querfeld U,Dello Strologo L,Noyan A,Yalcinkaya F,Topaloglu R,Webb NJ,Kemper MJ,Pape L,Bald M,Kranz B,Taylan C,Höcker B,Tönshoff B,Weber LT

    更新日期:2017-05-01 00:00:00

  • Attitudes toward xenotransplantation: A survey of parents and pediatric cardiac providers.

    abstract:BACKGROUND:Scientific advancements are occurring in cardiac xenotransplantation (XTx). However, there have been religious and social concerns surrounding this allotransplantation alternative. The purpose of this study was to explore the acceptance of XTx among stakeholders of the congenital heart disease (CHD) communit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13851

    authors: Padilla LA,Rhodes L,Sorabella RA,Hurst DJ,Cleveland DC,Dabal RJ,Cooper DK,Paris W,Carlo WF

    更新日期:2020-10-06 00:00:00

  • Psychosocial functioning in pediatric heart transplant recipients and their families.

    abstract::Across pediatric organ transplant populations, patient and family psychosocial functioning is associated with important health-related outcomes. Research has suggested that pediatric heart transplant recipients and their families are at increased risk for adverse psychosocial outcomes; however, recent investigation of...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13110

    authors: Cousino MK,Schumacher KR,Rea KE,Eder S,Zamberlan M,Jordan J,Fredericks EM

    更新日期:2018-03-01 00:00:00

  • Donor-specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival.

    abstract::There is increasing evidence that DSA are associated with poor graft survival, although there are little data in children. We aimed to describe the incidence of DSA in this group and to determine correlation with graft survival. HLA antibodies were analysed in 59 paediatric cardiac transplant recipients. Mean age 10.4...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01446.x

    authors: Irving C,Carter V,Parry G,Hasan A,Kirk R

    更新日期:2011-03-01 00:00:00

  • Long-term outcome after liver transplantation in children.

    abstract::Children (defined as under 18 yr of age) account for approximately 12.5% of all liver transplants in the United States. Even though the annual number of liver transplantation procedures remains relatively constant, the population of long-term survivors of liver transplantation has grown. Presently, the population of l...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2002.1r058.x

    authors: Bucuvalas JC,Ryckman FC

    更新日期:2002-02-01 00:00:00

  • Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation.

    abstract::In their provocative paper, "Lung transplantation and survival in children with cystic fibrosis," Liou and colleagues state that "Prolongation of life by means of lung transplantation should not be expected in children with cystic fibrosis. A prospective, randomized trial is needed to clarify whether and when patients...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00924.x

    authors: Sweet SC,Aurora P,Benden C,Wong JY,Goldfarb SB,Elidemir O,Woo MS,Mallory GB Jr,International Pediatric Lung Transplant Collaborative.

    更新日期:2008-03-01 00:00:00

  • En bloc kidney transplantation from infant donors younger than 10 months into pediatric recipients.

    abstract::Early graft loss and poor graft function limit the use of kidneys from infant donors. Six en bloc kidney transplantations were performed from infant donors younger than 10 months into pediatric recipients between November 2012 and September 2015 at our center. We retrospectively analyzed recipient and donor demographi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12845

    authors: Wang HY,Li J,Liu LS,Deng RH,Fu Q,Ko DS,Zhang HX,Deng SX,Wang CX

    更新日期:2017-03-01 00:00:00

  • Eltrombopag for secondary failure of platelet recovery post-allogeneic hematopoietic stem cell transplant in children.

    abstract::Secondary failure of platelet engraftment occurs in 20% of patients undergoing allogeneic HSCT and is associated with poor outcome. Currently, there are no guidelines for treatment of late thrombocytopenia and platelet transfusion is the mainstay of treatment. Here, we describe the use of Eltrombopag to treat secondar...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13017

    authors: Ali S,Gassas A,Kirby-Allen M,Krueger J,Ali M,Schechter T

    更新日期:2017-09-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Successful umbilical cord blood hematopoietic stem cell transplantation in pediatric patients with MDS/AML associated with underlying GATA2 mutations: two case reports and review of literature.

    abstract::Germline GATA2 mutations have been associated with a vast array of clinical manifestations, as well as hematological deficiencies and a propensity to AML or MDS. We present two cases of pediatric AML/MDS with underlying GATA2 mutations who underwent a successful umbilical cord hematopoietic stem cell transplantation u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12764

    authors: Mallhi K,Dix DB,Niederhoffer KY,Armstrong L,Rozmus J

    更新日期:2016-11-01 00:00:00

  • The role of continuous renal replacement therapy in the management of acute kidney injury associated with sinusoidal obstruction syndrome following hematopoietic cell transplantation.

    abstract::Maintaining fluid balance, pre- and post-MA-HCT is essential and usually requires frequent administration of diuretics. Hepatic sinusoidal obstructive syndrome is potentially life-threatening, especially when associated with AKI and MOF. This study describes six patients who developed AKI-associated SOS and diuretic-r...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13139

    authors: Raina R,Abusin GA,Vijayaraghavan P,Auletta JJ,Cabral L,Hashem H,Vogt BA,Cooke KR,Abu-Arja RF

    更新日期:2018-03-01 00:00:00

  • Liver transplantation for hepatoblastoma: indications and contraindications in the modern era.

    abstract::In the past 20 yr, a dramatic improvement has been achieved in the outcome of children with hepatoblastoma by combining cisplatin based chemotherapy and surgery. Treatment of patients in the USA is an exception to the rule that all patients should receive neoadjuvant chemotherapy. It is paramount that surgical resecti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00354.x

    authors: Otte JB,de Ville de Goyet J,Reding R

    更新日期:2005-10-01 00:00:00

  • Mycophenolate mofetil in pediatric renal transplantation: a single center experience.

    abstract::We assessed our long-term experience with regards to the safety and efficacy of MMF in our pediatric renal transplant population and compared it retrospectively to our previous non-MMF immunosuppressive regimen. Forty-seven pediatric renal transplants received MMF as part of their immunosuppressive protocol in the per...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01179.x

    authors: Raheem OA,Kamel MH,Daly PJ,Mohan P,Little DM,Awan A,Hickey DP

    更新日期:2011-05-01 00:00:00

  • Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients.

    abstract::There are limited published data on surveillance TBB for the identification of allograft rejection in infants after lung or heart-lung transplantation. We performed a retrospective review of children under one yr of age who underwent lung or heart-lung transplant at our institution. Since 2005, four infants were trans...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12125

    authors: Hayes D Jr,Baker PB,Kopp BT,Kirkby S,Galantowicz M,McConnell PI,Astor TL

    更新日期:2013-11-01 00:00:00

  • Monitoring and modulation of Epstein-Barr virus loads in pediatric transplant patients.

    abstract::A major risk faced by bone-marrow and solid organ transplant patients is the development of post-transplant lymphoproliferative disease or post-transplant lymphoma (PTLD). In pediatric transplantation, PTLD onset is often associated with a rapid rise in Epstein-Barr virus (EBV) load in peripheral blood mononuclear cel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00090.x

    authors: Orentas RJ,Schauer DW Jr,Ellis FW,Walczak J,Casper JT,Margolis DA

    更新日期:2003-08-01 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • High depression rates among pediatric renal replacement therapy patients: A cross-sectional study.

    abstract::Depression is common in pediatric chronic kidney disease (CKD) patients. Depression is associated with inferior long-term outcomes. There is a paucity of studies that evaluate depression and possible associated factors in children and adolescents requiring renal replacement therapy (RRT). Cross-sectional study using C...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13591

    authors: Rodriguez Cuellar CI,García de la Puente S,Hernández Moraria J,Bojórquez Ochoa A,Filler G,Zaltzman Grishevich S

    更新日期:2019-12-01 00:00:00