Site-specific quantitative analysis of overglycosylation of collagen in osteogenesis imperfecta using hydrazide chemistry and SILAC.

abstract：:Quantitative proteomics experiments, using for instance isobaric tandem mass tagging approaches, are conducive to measuring changes in protein abundance over multiple time points in response to one or more conditions or stimulations. The aim is often to determine which proteins exhibit similar patterns within and acro...

journal_title：Journal of proteome research

authors： Lee LH,Halu A,Morgan S,Iwata H,Aikawa M,Singh SA

更新日期：2019-02-01 00:00:00

abstract：:Natural disasters such as drought, extreme temperatures, and flooding can severely impact crop production. Understanding the metabolic response of crops threatened with these disasters provides insights into biological response mechanisms that can influence survival. In this study, a comparative analysis of GC-MS and ...

journal_title：Journal of proteome research

authors： Barding GA Jr,Béni S,Fukao T,Bailey-Serres J,Larive CK

更新日期：2013-02-01 00:00:00

abstract：:Beta-thalassemia results from mutations of the β-hemoglobin (Hbb) gene and reduced functional Hbb synthesis. Excess α-Hb causes globin chain aggregation, oxidation, cytoskeletal damage, and increased red blood cell clearance. These events result in anemia, altered iron homeostasis, and expansion of extramedullary eryt...

journal_title：Journal of proteome research

authors： Vallelian F,Gelderman-Fuhrmann MP,Schaer CA,Puglia M,Opitz L,Baek JH,Vostal J,Buehler PW,Schaer DJ

更新日期：2015-02-06 00:00:00

abstract：:The Baculoviral IAP repeat-containing protein 5 (BIRC5), also known as inhibitor of apoptosis protein survivin, is a member of the chromosomal passenger complex and a key player in mitosis. To investigate the function of BIRC5 in liver regeneration, we analyzed a hepatocyte-specific BIRC5-knockout mouse model using a ...

journal_title：Journal of proteome research

authors： Bracht T,Hagemann S,Loscha M,Megger DA,Padden J,Eisenacher M,Kuhlmann K,Meyer HE,Baba HA,Sitek B

更新日期：2014-06-06 00:00:00

abstract：:Blood is an ideal window for viewing our health and disease status. Because blood circulates throughout the entire body and carries secreted, shed, and excreted signature proteins from every organ and tissue type, it is thus possible to use the blood proteome to achieve a comprehensive assessment of multiple-organ phy...

journal_title：Journal of proteome research

authors： Sun B,Utleg AG,Hu Z,Qin S,Keller A,Lorang C,Gray L,Brightman A,Lee D,Alexander VM,Ranish JA,Moritz RL,Hood L

更新日期：2013-05-03 00:00:00

abstract：:Plant secretory (Class III) peroxidases are redox enzymes that rely on N-glycosylation for full enzyme activity and stability. Peroxidases from palm tree leaves comprise the most stable and active plant peroxidases characterized to date. Herein, site-specific glycosylation and microheterogeneity of windmill palm tree ...

journal_title：Journal of proteome research

authors： Baker MR,Tabb DL,Ching T,Zimmerman LJ,Sakharov IY,Li QX

更新日期：2016-06-03 00:00:00

abstract：:Russell and colleagues deserve credit for being the first to use a QconCAT standard to simultaneously quantify both the wild-type and mutant peptides of a protein (i.e., CYP2B6) ( J. Proteome Res. 2013, 12 (12), 5934-5942. DOI: 10.1021/pr400279u). However, the rationale of their study was entirely different from ours ...

journal_title：Journal of proteome research

authors： Shi J,Wang X,Zhu H,Jiang H,Wang D,Nesvizhskii A,Zhu HJ

更新日期：2019-03-01 00:00:00

abstract：:Bacillus Amyloliquefaciens SQR9 is a well-investigated plant growth-promoting rhizobacteria with strong root colonization capability. To identify the key proteins involved in in situ root colonization and biofilm formation, the proteomic profiles of planktonic and root colonized SQR9 cells were compared. A total of 75...

journal_title：Journal of proteome research

authors： Qiu M,Xu Z,Li X,Li Q,Zhang N,Shen Q,Zhang R

更新日期：2014-12-05 00:00:00

abstract：:Protein-protein control recognition remains a huge challenge, and its development depends on understanding the chemical and biological mechanisms by which these interactions occur. Here we describe a protein-protein control recognition technique based on the dominant electrostatic interactions occurring between the pr...

journal_title：Journal of proteome research

authors： Han S,Yin S,Yi H,Mouhat S,Qiu S,Cao Z,Sabatier JM,Wu Y,Li W

更新日期：2010-06-04 00:00:00

abstract：:The nation-wide electronic health record database acts as an interoperable repository of health data obtained throughout citizen contacts with health care providers. This system improves accessibility for citizens and researchers to health data with the ability to assign context to disease development. In that system,...

journal_title：Journal of proteome research

authors： Sepper R,Ross P,Tiik M

更新日期：2011-01-07 00:00:00

abstract：:We assessed proteomic patterns in breast cancer using MALDI MS and laser capture microdissected cells. Protein and peptide expression in invasive mammary carcinoma versus normal mammary epithelium and estrogen-receptor positive versus estrogen-receptor negative tumors were compared. Biomarker candidates were identifie...

journal_title：Journal of proteome research

authors： Sanders ME,Dias EC,Xu BJ,Mobley JA,Billheimer D,Roder H,Grigorieva J,Dowsett M,Arteaga CL,Caprioli RM

更新日期：2008-04-01 00:00:00

abstract：:Triply and doubly charged iTRAQ ( isobaric tagging for relative and absolute quantitation) labeled peptide cations from a tryptic peptide mixture of bovine carbonic anhydrase II were subjected to electron transfer ion/ion reactions to investigate the effect of charge bearing modifications associated with iTRAQ on the ...

journal_title：Journal of proteome research

authors： Han H,Pappin DJ,Ross PL,McLuckey SA

更新日期：2008-09-01 00:00:00

abstract：:Clematis terniflora DC. has potential pharmaceutical value; on the contrary, high-level UV-B irradiation with dark treatment led to the accumulation of secondary metabolites. Metabolomic and proteomic analyses of leaf of C. terniflora were performed to investigate the systematic response mechanisms to high-level UV-B ...

journal_title：Journal of proteome research

authors： Yang B,Wang X,Gao C,Chen M,Guan Q,Tian J,Komatsu S

更新日期：2016-08-05 00:00:00

abstract：:Untargeted GC-TOF-MS analysis proved to be a suitable analytical platform to determine alterations in the metabolic profile. Several metabolic pathways were found to be altered in a first clinical study comparing smokers against nonsmokers. Subsequently, we conducted a clinical diet-controlled study to investigate alt...

journal_title：Journal of proteome research

authors： Goettel M,Niessner R,Mueller D,Scherer M,Scherer G,Pluym N

更新日期：2017-10-06 00:00:00

abstract：:The increasing occurrence of multidrug resistant tuberculosis exerts a major burden on treatment of this infectious disease. Thioridazine, previously used as a neuroleptic, is active against extensively drug resistant tuberculosis when added to other second- and third-line antibiotics. By quantitatively studying the p...

journal_title：Journal of proteome research

authors： de Keijzer J,Mulder A,de Haas PE,de Ru AH,Heerkens EM,Amaral L,van Soolingen D,van Veelen PA

更新日期：2016-06-03 00:00:00

abstract：:Coronary artery disease is one of the most frequent causes of morbidity and mortality worldwide. It is even more prevalent in patients with type 2 diabetes mellitus who suffer from obesity and increased accumulation of epicardial fat with a possible contributing role in the development of coronary artery disease. We p...

journal_title：Journal of proteome research

authors： Tomášová P,Čermáková M,Pelantová H,Vecka M,Kratochvílová H,Lipš M,Lindner J,Ivák P,Netuka I,Šedivá B,Haluzík M,Kuzma M

更新日期：2020-10-02 00:00:00

abstract：:As large-scale cross-linking data becomes available, new software tools for data processing and visualization are required to replace manual data analysis. XLink-DB serves as a data storage site and visualization tool for cross-linking results. XLink-DB accepts data generated with any cross-linker and stores them in a...

journal_title：Journal of proteome research

authors： Zheng C,Weisbrod CR,Chavez JD,Eng JK,Sharma V,Wu X,Bruce JE

更新日期：2013-04-05 00:00:00

abstract：:We report the use of chemical derivatization with MALDI-MS/MS analysis for de novo sequence analysis. Using three frequently used homology-based search algorithms, we were able to identify more than 40 proteins from banana, a nonmodel plant with unsequenced genome. Furthermore, this approach allowed the identification...

journal_title：Journal of proteome research

authors： Samyn B,Sergeant K,Carpentier S,Debyser G,Panis B,Swennen R,Van Beeumen J

更新日期：2007-01-01 00:00:00

abstract：:TGFBR2 serves as an initial regulator of the TGF-β signaling pathway, and loss or reduction of its expression can lead to uncontrolled cell growth. This study was conducted to further explore the mechanism of TGFBR2/SMAD4 on the migration and proliferation of CC cells. Here, TGFBR2 and SMAD4 expressions in CC cells an...

journal_title：Journal of proteome research

authors： Yuan J,Yi K,Yang L

更新日期：2020-08-07 00:00:00

abstract：:The intake of 3,4-methylenedioxymethamphetamine (MDMA) is known to increase several endogenous substances involved in steroid and inflammation pathways. Untargeted metabolomics screening approaches can determine biochemical changes after drug exposure and can reveal new pathways, which might be involved in the pharmac...

journal_title：Journal of proteome research

authors： Boxler MI,Streun GL,Liechti ME,Schmid Y,Kraemer T,Steuer AE

更新日期：2018-08-03 00:00:00

abstract：:Numerous reports have predicted/hypothesized a role for probenazole-induced protein (PBZ1) as a molecular marker in rice self-defense mechanism. However, the precise function of PBZ1 remains unknown. In the present study, we examined PBZ1 as a putative cell death marker in rice. For this, we focused our attention on a...

journal_title：Journal of proteome research

authors： Kim ST,Kim SG,Kang YH,Wang Y,Kim JY,Yi N,Kim JK,Rakwal R,Koh HJ,Kang KY

更新日期：2008-04-01 00:00:00

abstract：:Spectral library searching is a popular approach for MS/MS-based peptide identification. Because the size of spectral libraries continues to grow, the performance of searching algorithms is an important issue. This technical note introduces a strategy based on a minimum shared peak count between two spectra to reduce ...

journal_title：Journal of proteome research

authors： Vu TN,Bittremieux W,Valkenborg D,Goethals B,Lemière F,Laukens K

更新日期：2014-09-05 00:00:00

abstract：:The effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted in urine were analyzed using GC/MS in conjunction with multivariate and univariate statistical techniques. SD rats were subjected to two kinds of acute stress and c...

journal_title：Journal of proteome research

authors： Wang X,Zhao T,Qiu Y,Su M,Jiang T,Zhou M,Zhao A,Jia W

更新日期：2009-05-01 00:00:00

abstract：:Outbreaks of porcine epidemic diarrhea virus (PEDV) have caused significant lethality rates in neonatal piglets, which pose a serious threat to the swine industry worldwide. Available commercial vaccines fail to protect against the emergence of high virulence of PEDV variants. Therefore, the endemic state of the PEDV ...

journal_title：Journal of proteome research

authors： Ye Y,Zhu J,Ai Q,Wang C,Liao M,Fan H

更新日期：2019-04-05 00:00:00

abstract：:In systemic amyloidosis, accumulation of misfolded proteins as extracellular amyloid fibrils in tissues causes severe organ dysfunction, but the molecular events of tissue damage related to amyloid deposition are still largely unknown. Through the use of the MudPIT proteomic approach, comprehensive protein profiles of...

journal_title：Journal of proteome research

authors： Brambilla F,Lavatelli F,Di Silvestre D,Valentini V,Palladini G,Merlini G,Mauri P

更新日期：2013-12-06 00:00:00

abstract：:The study of protein phosphorylation has grown exponentially in recent years, as it became evident that important cellular functions are regulated by phosphorylation and dephosphorylation of proteins on serine, threonine and tyrosine residues. The use of immobilized metal affinity chromatography (IMAC) to enrich phosp...

journal_title：Journal of proteome research

authors： Aprilita NH,Huck CW,Bakry R,Feuerstein I,Stecher G,Morandell S,Huang HL,Stasyk T,Huber LA,Bonn GK

更新日期：2005-11-01 00:00:00

abstract：:Cancer stem cells are responsible for tumor formation through self-renewal and differentiation into multiple cell types and thus represent a new therapeutic target for tumors. Glycoproteins play a critical role in determining the fates of stem cells such as self-renewal, proliferation, and differentiation. Here we app...

journal_title：Journal of proteome research

authors： He J,Liu Y,Zhu TS,Xie X,Costello MA,Talsma CE,Flack CG,Crowley JG,Dimeco F,Vescovi AL,Fan X,Lubman DM

更新日期：2011-01-07 00:00:00

abstract：:The development of plasma biomarkers has proven to be more challenging than initially anticipated. Many studies have reported lists of candidate proteins rather than validated candidate markers with an assigned performance to a specific clinical objective. Biomarker research necessitates a clear rational framework wit...

journal_title：Journal of proteome research

authors： Surinova S,Schiess R,Hüttenhain R,Cerciello F,Wollscheid B,Aebersold R

更新日期：2011-01-07 00:00:00

abstract：:Breast cancer is a leading cancer in women and is considered to be the second-most common metastatic cancer following lung cancer. An estimated 10-16% of breast cancer patients are suffering from brain metastasis, and the diagnostic cases of breast cancer brain metastasis are increasing. Nevertheless, the mechanisms b...

journal_title：Journal of proteome research

authors： Peng W,Goli M,Mirzaei P,Mechref Y

更新日期：2019-10-04 00:00:00

abstract：:Sulfur trafficking systems are multiprotein systems that synthesize sulfur-containing cofactors such as iron-sulfur clusters. The sulfur is derived enzymatically from cysteine and transferred between nucleophilic cysteine residues within proteins until incorporation into the relevant cofactor. As these systems are poo...

journal_title：Journal of proteome research

authors： Bolstad HM,Wood MJ

更新日期：2010-12-03 00:00:00