Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities.

Abstract:

OBJECTIVE:Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results. METHODS:Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed. RESULTS:Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P < 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit. CONCLUSIONS:Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present.

journal_name

J Comput Assist Tomogr

authors

Hanson EH,Roach CJ,Day KJ,Peters KR,Bradley WG Jr,Ghosh K,Patton PW,McMurray RC,Orrison WW Jr

doi

10.1097/RCT.0b013e31828004bb

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

212-21

issue

2

eissn

0363-8715

issn

1532-3145

pii

00004728-201304000-00013

journal_volume

37

pub_type

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