Posterior reversible encephalopathy syndrome (PRES) with immune system activation, VEGF up-regulation, and cerebral amyloid angiopathy.

Abstract:

:The case of a 75-year-old man with a history of lymphoma, recent upper respiratory tract infection, and a protracted course of encephalopathy is presented. Radiologically, findings were consistent with posterior reversible encephalopathy syndrome. A brain biopsy revealed evidence of endothelial activation, T-cell trafficking, and vascular endothelial growth factor expression, suggesting that systemic immune system activation may be involved with triggering posterior reversible encephalopathy syndrome. In addition, underlying cerebral amyloid angiopathy may have contributed to the initial nonclassical edema distribution by compromising autoregulatory blood flow mechanisms.

journal_name

J Comput Assist Tomogr

authors

Kofler J,Bartynski WS,Reynolds TQ,Lieberman FS,Murdoch GH,Hamilton RL

doi

10.1097/RCT.0b013e3181f31917

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

39-42

issue

1

eissn

0363-8715

issn

1532-3145

journal_volume

35

pub_type

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