Abstract:
OBJECTIVE:The purpose of our study was to quantify peritumoral brain edema (PTE) in vivo using NMR relaxation time imaging, as the longitudinal relaxation time T1 is proportional to tissue water content, and to use the method for monitoring the effects of glucocorticoids (GCCs) on PTE in brain tumor patients as a function of time. MATERIALS AND METHODS:Relaxation time imaging (T1 maps) was done on a 1.5 T MR scanner on 23 brain tumor patients [13 cerebral metastases (METs), 10 intracranial meningiomas (MMs), and 9 benign and 1 anaplastic MM] before, and 1, 3, and 7 days after initiation of GCC treatment (dexamethasone 0.26-0.64 mg/kg bw). In addition, 7 patients were studied for 14-63 days of treatment. Imaging analysis included mean T1 of the edema area as a function of time, and an image histogram evaluation technique, which measures 50% of the edema area, where T1 is highest (corresponding to the highest water content of the area), termed the "super-edema." Using a conversion equation, mean T1 in the edema area was recalculated into a percent of tissue water content. RESULTS:After 7 days of GCC treatment total edema area was reduced by 10.3% in the MET patients. The average reduction in mean T1 was 4.6% after 24 h of treatment and 13.5% after 7 days. Expressed in terms of percent tissue water content, the average edema resorption rate in the MET patients was 0.4 +/- 0.1% H2O/day (p < 0.02). Super-edema area was reduced by 64% after 7 days (p < 0.0001). None of the benign MMs responded to GCC treatment, either in edema size or in mean T1, unlike the anaplastic type, in which there was a response comparable to that in the MET patients. The effect of GCCs in up to 63 days of treatment is demonstrated. It is shown that after 40-63 days of GCC treatment, PTE water content is close to the upper normal range for white matter. CONCLUSION:PTE is heterogeneous in terms of the spatial distribution of T1 and, thereby, water content. GCCs reduce T1 in PTE around cerebral metastases significantly after a few days of treatment, possibly through a mechanism that reduces edema production below the level of edema resorption. PTE surrounding benign MM was not affected by GCC treatment, contrary to one anaplastic MM, which leads to the speculation that malignant tumors may produce substances that are affected by GCCs and are prerequisites for a GCC effect. Significant reductions in the highest T1 area (super-edema area) were observed after 24 h of treatment. The anti-edema effect of GCC may last at least 63 days. A lower dose-dependent threshold for the effect seems to exist. The possible mechanisms of actions of the GCCs on PTE are discussed.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Andersen C,Astrup J,Gyldensted Cdoi
10.1097/00004728-199407000-00001subject
Has Abstractpub_date
1994-07-01 00:00:00pages
509-18issue
4eissn
0363-8715issn
1532-3145journal_volume
18pub_type
杂志文章abstract:OBJECTIVE:The objective of the study was to characterize the enhancement pattern of hyperfunctioning parathyroid adenomas on multiphase multidetector computed tomography (CT) or 4-dimensional CT. METHODS:We retrospectively studied the enhancement patterns of 48 pathologically confirmed parathyroid adenomas with 4-dime...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31822a1e70
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To describe CT findings of portal vein anomaly with total ramification of the intrahepatic portal branches from the right umbilical vein. METHODS:Retrospective analysis was performed in 6 patients with portal vein anomaly with total ramification of the intrahepatic portal branches from the right umbilican vein...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000165905.06031.b0
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether computed tomography (CT) angiography with machine learning (ML) can be used to predict the rapid growth of abdominal aortic aneurysm (AAA). MATERIALS AND METHODS:This retrospective study was approved by our institutional review board. Fifty consecutive patie...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000958
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIMS:To prospectively determine the accuracy of liver fat quantification with magnetic resonance imaging (MRI). PATIENTS AND METHODS:The population consisted of 40 patients (mean age, 52.5 years; range, 23-78 years). The same day, all patients underwent MRI and ultrasonography-guided liver biopsy. The h...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318199d883
更新日期:2009-09-01 00:00:00
abstract::This article reviews the value of magnetic resonance imaging (MRI) for the diagnosis of ovarian tumors especially when ultrasonography is indeterminate. Although ultrasonography is the first imaging technique used to investigate suspected pelvic masses, it has a limited capacity for tissue characterization. In additio...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0b013e31815881ef
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:Acinar cell carcinoma (ACC) is a subtype of pancreatic neoplasm sufficiently rare that its imaging has not been fully analyzed. The purpose of this article is to present the computed tomography (CT) appearance of ACC of the pancreas. METHODS:Clinical data and CT studies of 10 patients (7 male and 3 female) wit...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200403000-00005
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate if Hounsfield unit (HU) values from virtual noncontrast (VNC) images derived from portal venous phase spectral-detector computed tomography can help to differentiate adrenal adenomas and metastases. METHODS:Spectral-detector computed tomography datasets of 33 patients...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000982
更新日期:2021-01-01 00:00:00
abstract::The primitive trigeminal artery is the most common of the persistent carotid-basilar anastomoses with an angiographic incidence of 0.6%. Fifteen cases of aneurysms of a persistent primitive trigeminal artery have been reported in the literature. A 16th patient is presented in whom an incidental trigeminal artery aneur...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-198809010-00022
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess the feasibility of performing diagnostic-quality contrast-enhanced excretory magnetic resonance urography (eMRU) at 3T, examining both image quality and diagnostic accuracy for a range of urinary tract abnormalities. METHODS:The diuretic-enhanced 3T eMRUs of 37 patie...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3182711fd9
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. METHODS:Thirty patients with suspected or known coronary artery...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000160426.41014.b1
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:The goals of this work were to evaluate the practical utility of MRI to quantify myocardial mass in patients with hypertrophic cardiomyopathy (HCM), define the differences in myocardial mass measurements obtained with three-dimensional and geometric MR methods in patients with normal left ventricular morphology...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199907000-00018
更新日期:1999-07-01 00:00:00
abstract::A simple technique using stereotactic needle placement for retrobulbar anesthesia is reported. The method utilizes a CT-guided stereotactic device that permits precise intraconal injection of local anesthetics; in addition, the risk of injury to muscles, vessels, eyeglobe, or optic nerve is substantially reduced. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199009000-00043
更新日期:1990-09-01 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the magnetic resonance imaging findings of decidualized endometriotic cysts in comparison with endometriotic cysts associated with ovarian cancers. METHODS:Eighteen decidualized endometriotic cysts and 24 ovarian cancers were retrospectively assessed on height, signa...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000136
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:The dimensions of the optic nerves, chiasm, and tracts were determined in normal patients and in patients with clinical evidence of optic atrophy to establish whether there was a significant difference between the two groups. MATERIALS AND METHODS:The authors analyzed thin section coronal MRI of 110 patients...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199309000-00003
更新日期:1993-09-01 00:00:00
abstract::The use of magnetic resonance (MR) to preoperatively evaluate patients with primary hyperparathyroidism was assessed using a 1.5 T system and surface coil reception. Twenty-five patients with primary hyperparathyroidism were studied before surgical exploration. Axial images, 5 mm thick, were obtained from the thyroid ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198709000-00023
更新日期:1987-09-01 00:00:00
abstract::Our retrospective study of 230 computed tomographic (CT) studies of hepatic masses yielded 28 cases (12.2%) which contained calcification. Calcific deposits were noted in 9 of 59 patients (15.3%) with hepatocellular carcinoma (HCC), 15 of 82 patients (18.3%) with liver metastases from colorectal carcinoma (MCRC), 2 of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198302000-00015
更新日期:1983-02-01 00:00:00
abstract::We reviewed our clinical experience of the past 1 1/2 years using computed tomography (CT) in cases of suspected renal vein thrombosis; we detected three cases and correctly excluded renal vein thrombosis in an additional three patients. Because of our limited clinical experience, we surgically created left renal vein...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE:To determine if gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) cholangiography can detect and localize bile duct leaks in postcholecystectomy patients. MATERIAL AND METHODS:Four blinded independent radiologists performed a retrospective review of 16...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000083
更新日期:2014-07-01 00:00:00
abstract::The identification of fat within a focal or diffuse mediastinal lesion significantly narrows the differential diagnosis. In many cases, a specific diagnosis can be suggested on the basis of CT findings. In this article, we illustrate and review the characteristic CT features of common and uncommon fat attenuation lesi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200111000-00010
更新日期:2001-11-01 00:00:00
abstract::Thirty-three patients with rheumatoid arthritis had computed tomographic examination of the craniocervical junction. This demonstrated soft tissue features which have not previously been described in published reports. A low attenuation lesion between the odontoid and the transverse ligament shown in 11 patients was c...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198302000-00006
更新日期:1983-02-01 00:00:00
abstract::Recently, the application of intravenous gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) has been shown to improve the detection of intradural extramedullary spinal disease in adults. The ability of Gd-DTPA enhanced magnetic resonance (MR) to detect intradural extramedullary spinal metastases was studied in p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199009000-00009
更新日期:1990-09-01 00:00:00
abstract::We describe a patient with CT-proven ischemic infarction of the left middle cerebral artery (MCA) territory. The emergency CT, on admission, was suggestive of intracranial internal carotid artery dissection by demonstrating gaseous gap defects in the arterial wall and a subsequent thromboembolic process in the MCA. To...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200211000-00015
更新日期:2002-11-01 00:00:00
abstract::Neurofibromatosis or von Recklinghausen disease usually is a readily diagnosed entity, characterized by typical cutaneous lesions and a strong family history. In a variant of the usual disease, peripheral neurofibromatosis, these stigmata may be absent and accurate diagnosis may be elusive. We present a patient withou...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198304000-00039
更新日期:1983-04-01 00:00:00
abstract::The magnetic resonance imaging (MRI) findings in 2 cases of ovarian cancer arising in an endometrioma are presented. In both cases, the cancer was evident as an enhancing mass within a blood-filled adnexal cyst. The MRI findings of an enhancing mass within a blood-filled adnexal cyst should prompt consideration of ova...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200411000-00018
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To perform a clinical and payer-based analysis of the value of dual-energy computed tomography (DECT) for workup of incidental abdominal findings. METHODS:This was a single-center, retrospectively designed, Health Insurance Portability and Accountability Act-compliant study approved by our institutional revi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000886
更新日期:2019-07-01 00:00:00
abstract::Seven patients with supratentorial infarction were studied by means of serial nuclear magnetic resonance imaging using saturation recovery (SR) and proton density (PD) sequences. The earliest changes were visible in the more sensitive T1 dependent images (SR) and may reflect the cytotoxic component of ischemic brain e...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Due to the low prevalence of hemangiopericytomas (HPCs), data on the biophysiological characteristics of this tumor are rare. Positron emission tomography (PET) demonstrated a sixfold increased uptake of [11C]methionine and hyperperfusion in the HPC, whereas glucose utilization was decreased in this area. This low glu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199905000-00008
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine the normal anatomical features and variations of the bronchial arterial system and to determine the relationship among ectopic bronchial arteries, location (right-left) of the bronchial arteries, and variations of the aortic arch in patients as well as the sex of the patients who underwent multid...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3182073c27
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation. METHODS:Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181bb0d32
更新日期:2010-03-01 00:00:00
abstract::Aneurysms arising from the extracranial carotid arteries are uncommon lesions. Clinically, they may present as lateral masses in the superior cervical area, as medial masses in the tonsillar fossa or parapharyngeal region, or as a mass palpable in both areas. Tenderness or pain may or may not be present. Pulsation is ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00