Gadolinium DTPA enhanced MR imaging of ACTH-secreting microadenomas of the pituitary gland.

Abstract:

:Gadolinium diethylenetriamine pentaacetic acid (DTPA) enhanced magnetic resonance imaging was performed in eight patients with Cushing disease and surgically proven pituitary microadenomas. A 1.5 T scanner was used with 3 mm contiguous slices. Short repetition times (TR), short echo times (TE), and long TR, long TE sequences were obtained before and serially after intravenous administration of Gd-DTPA. Three of eight (38%) microadenomas were undetectable both without and with Gd-DTPA: one post-Gd-DTPA scan was false positive on the side opposite the adenoma. Hemihypophysectomy based on a petrosal sinus adrenocorticotropic hormone (ACTH) gradient cured all three patients. Two microadenomas (25%) were visible as hypointense foci following Gd-DTPA but not on unenhanced scans. The remaining three microadenomas (38%) were seen before and after Gd-DTPA on T1-weighted images. In this small series of ACTH-producing microadenomas, one-third were seen on unenhanced 1.5 T scans, one-third were seen only after Gd-DTPA, and one-third were not imaged even with Gd-DTPA enhancement.

journal_name

J Comput Assist Tomogr

authors

Doppman JL,Frank JA,Dwyer AJ,Oldfield EH,Miller DL,Nieman LK,Chrousos GP,Cutler GB Jr,Loriaux DL

doi

10.1097/00004728-198809010-00002

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

728-35

issue

5

eissn

0363-8715

issn

1532-3145

journal_volume

12

pub_type

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