Abstract：
:Because current therapies have not always been successful and effective, the possibility of regenerating the nucleus pulposus (NP) through a tissue-engineered construct offers a novel therapeutic possibility for symptomatic degenerative disc diseases (DDDs). However, more research is necessary to identify the optimal scaffold, cell type and mixture of signal factors needed for NP regeneration. Numerous possible scaffolds for NP regeneration have been investigated; they have many shortcomings in common. Various biological scaffolds derived from decellularized tissue and organs have been successfully used in tissue engineering and received approval for use in humans. Regretfully, harvesting of human NP is difficult and only small amounts can be obtained. The macromolecules of cartilage, which include collagen and proteoglycan aggrecan, are similar to those of the extracellular matrix of immature NP. Recent studies have shown that adipose-derived stem cells (ADSC) can be induced to develop NP-like phenotypes when stimulated by appropriate signals. We thus reasonably postulated that an ideal NP scaffold for tissue engineering could be fabricated from decellularized cartilage matrix (DCM). Furthermore, a combination of ADSCs and DCM-derived biomimetic scaffolds would be advantageous in NP tissue engineering and, in the long run, could become an effective treatment option for symptomatic DDD.
journal_name
Orthop Surgjournal_title
Orthopaedic surgeryauthors
Yang Q,Zhao YH,Xia Q,Xu BS,Ma XL,Liu Y,Hu YC,Li HF,Miao J,Wang T,Ma JX,Sun XLdoi
10.1111/os.12020subject
Has Abstractpub_date
2013-02-01 00:00:00pages
60-3issue
1eissn
1757-7853issn
1757-7861journal_volume
5pub_type
杂志文章abstract：OBJECTIVE:To explore the effect of kartogenin (KGN) on proliferation and chondrogenic differentiation of human umbilical cord mesenchymal stem cells (hUCMSC) in vitro, and the synergistic effects of KGN and transforming growth factor (TGF)-β3 on hUCMSC. METHODS:Human umbilical cord mesenchymal stem cells were isolated...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12691
更新日期：2020-06-01 00:00:00
abstract：:Gouty arthritis is an extremely painful condition that causes functional impairment. Gouty arthritis has become increasingly complex because of multiple comorbidities, iatrogenic factors and hyperuricemia that is refractory to treatment. In this review, we present a general overview of gouty arthritis including its pa...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,评审
doi：10.1111/os.12024
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To investigate the outcomes of total knee arthroplasty (TKA) in patients with a prior femoral or tibial fracture, and identify the risk factors for surgical site complications and reoperations. METHODS:Seventy-one TKAs performed in 71 patients with a prior tibial or femoral fracture between January 2005 and ...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12610
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To review the long-term clinical results after revision surgery and the relationship between the different clinical variables involved with a failed total knee arthroplasty (TKA) and its evolution to provide a better understanding of the current treatment methods. METHODS:The present study involved 89 subjec...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12593
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To investigate a stem-adjusted preparation of the femur with a kinked reamer and to determine whether this approach results in higher primary stability of a kinked stem than straight reaming of the intramedullary canal. METHODS:Ten cementless stems with a kinked design were implanted in synthetic femurs afte...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12490
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To retrospectively investigate the experience at one urban level one trauma center with gunshot femoral fractures with vascular injury and to examine the implication of surgical sequence with regards to short-term complications and ischaemia time. METHODS:We performed a retrospective study of 24 patients tre...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/j.1757-7861.2012.00186.x
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To investigate the influence of preoperative osteopenia/osteoporosis on periprosthetic bone loss after total hip arthroplasty (THA) and the efficiency of zoledronate (ZOL) treatment in periprosthetic bone preservation. METHODS:This multicenter, prospective cohort study was conducted in four centers between A...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,多中心研究
doi：10.1111/os.12513
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the mid-term outcomes of transoral atlantoaxial reduction plate (TARP) internal fixation for the treatment of irreducible atlantoaxial dislocation. METHODS:From April 2003 to April 2005, 31 patients with irreducible atlantoaxial dislocation were treated with TARP internal fixation. The average ag...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/j.1757-7861.2010.00077.x
更新日期：2010-05-01 00:00:00
abstract：:The authors describe a hybrid technique that involves a combination of open decompression and posterior lumbar interbody fusion (PLIF) and percutaneously inserted pedicle screws. This technique allows performance of PLIF and decompression via a midline incision and approach without compromising operative time and visu...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12042
更新日期：2013-05-01 00:00:00
abstract：:To observe the morphology character of the anterior epidural space at the L4-5 disc level and to provide an anatomical basis for safely and accurately performing a percutaneous endoscopic lumbar discectomy (PELD). Fifty-five cases with L5 S1 lumbar disc herniation were included in this study, and cases with L4-5 disea...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12325
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To discuss the methods, timing and clinical outcomes of surgical treatment for open pilon fractures. METHODS:From April 2003 to July 2008, 28 patients with open pilon fractures were treated. All had type C fractures according to the Arbeitsgemeinschaft für osteosynthesefragen-Association for the Study of Int...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/j.1757-7861.2010.00113.x
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:We analyzed chondrosarcomas in long bones to assess whether Grade I and II chondrosarcomas should both be grouped as low grade malignant tumors (musculoskeletal Tumor Society Stage I or Stage II), and to explore rational surgical treatment for Grade I and II chondrosarcomas. METHODS:We retrospectively review...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/j.1757-7861.2009.00020.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To describe the technique and analyze the outcomes of joint-preserving surgical treatments which included anatomical reconstruction or alignment correction for talar malunions or nonunions, and avoid development of degenerative changes in the adjacent joints. METHODS:Eight patients who had painful talar malu...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12301
更新日期：2017-02-01 00:00:00
abstract：:In the realm of orthopaedics, the terrible triad of the elbow is infamous, not simply because the prognosis is poor for most patients, but also, maybe to a greater extent, because the unique name of this malady attracts considerable attention and interest in both doctors and patients. The adjective terrible is bestowe...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,评审
doi：10.1111/os.12149
更新日期：2015-02-01 00:00:00
abstract：:Herein is described cortical bone trajectory (CBT), a new path for pedicle screw insertion for lumbar vertebral fusion. Because the points of insertion are under the end of the inferior articular process, and because the screws are inserted toward the lateral side, there is less soft tissue development than with the c...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12122
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Femoral avulsion fracture of the posterior cruciate ligament (PCL) in association with meniscus tear is extremely rare in children, and similar cases are not available in the existing literature. CASE PRESENTATION:In this paper, we present a case of a 9-year-old boy treated by an arthroscopic repair techniq...
journal_title：Orthopaedic surgery
pub_type：
doi：10.1111/os.12636
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:We create a new S1 cortical screw trajectory technique using 3D reconstruction and the finite element (FE) method to provide a more reliable theoretical basis for clinical practices and to advance internal fixation technology for treatment of lumbosacral degenerative diseases. METHODS:This retrospective stud...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12624
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To compare the clinical efficacy of intramedullary nail fixation for intertrochanteric fractures assisted by orthopaedic robot navigation and the traditional intramedullary nail fixation in elderly patients, and to investigate the application advantages of intramedullary nail fixation for femoral intertrochan...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12447
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To examine the results of an anular closure device for prevention of lumbar disc reherniation in daily routine practice. METHODS:Fifty patients with large anular defects were treated with limited discectomy and a bone-anchored anular closure device. The device physically occludes the defect in the anulus fib...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12495
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:Giant cell tumors of bone (GCTs) are bone destructive neoplasms, the bone resorption being mediated by osteoclasts. Given that microRNAs are crucially involved in tumorigenesis and the modulation of cell fate and behavior, they are promising candidates for regulation of osteoclastogenesis. However, no reliabl...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12231
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS:Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rat...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12321
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:Relatively few studies have reported on the morphology of the supracondylar femur, which is a fundamental factor affecting prosthetic reconstruction. The objectives of the present study were to measure the morphological parameters of the supracondylar femur, to classify the supracondylar femur, and to provide...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12443
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To assess the clinical efficacy of mini-invasive transforaminal lumbar interbody fusion (TLIF) through the Wiltse approach for treating lumbar spondylolytic spondylolisthesis. METHODS:In this retrospective controlled study, 69 cases with lumbar spondylolytic spondylolisthesis treated in Qilu hospital from Ap...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,随机对照试验
doi：10.1111/os.12224
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical outcomes of anterior and posterior instrumentation with different debridement and graft fusion methods for multi-level contiguous thoracic spinal tuberculosis. METHODS:We retrospectively evaluated 81 patients with multi-level contiguous thoracic spinal tuberculosis who underwent ante...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12288
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical efficacy of internal fixation versus hemiarthroplasty in the treatment of unstable intertrochanteric fractures in the elderly. METHODS:A search was conducted in PubMed, Web of Science, Embase, and Cochrane Library databases up to April 2020. The present study compared internal fixati...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,评审
doi：10.1111/os.12736
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:To assess the benefits of use of a tourniquet in one limb in patients undergoing simultaneous bilateral total knee arthroplasty (TKA). METHODS:A prospective randomized trial was designed to evaluate the outcomes of unilateral tourniquet use during simultaneous bilateral TKA. A total of 52 (36 women and 16 me...
journal_title：Orthopaedic surgery
pub_type： 杂志文章,随机对照试验
doi：10.1111/os.12329
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To introduce a microsurgical suture technique for repair of dural tear under posterior lumbar disk scope. METHODS:Micro endoscopic discectomy was performed on a 26-year-old male under local anesthesia. During the operation, an irregular tear of about 1.0 cm was inadvertently made in the dura.The cauda equina...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/j.1757-7861.2011.00135.x
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical effect of the minimally invasive transforaminal lumbar interbody fusion combined with posterolateral fusion and unilateral fixation using a tubular retractor in the management of degenerative lumbar disease. METHODS:A retrospective analysis was conducted to analyze the clinical outco...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12345
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To investigate the bone hardness of different anatomical regions of the human radius and its impact on the pullout strength of screws. METHODS:Fresh radius bones were obtained from three donated cadavers. They were divided into three parts: proximal metaphysis, shaft, and distal metaphysis. The proximal meta...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12436
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To investigate the compensatory mechanism of maintaining the sagittal balance in degenerative lumbar scoliosis patients with different pelvic incidence (PI). METHODS:This was a retrospective imaging observation study. Patients in our department with degenerative lumbar scoliosis between 2017 and 2019 were re...
journal_title：Orthopaedic surgery
pub_type： 杂志文章
doi：10.1111/os.12805
更新日期：2020-12-01 00:00:00
