Abstract：
:Insulin plays diverse roles, including learning and memory, in the central nervous system. SIRT1 has been reported to be involved in the processes of normal learning, memory, and synaptic plasticity. However, whether insulin is directly involved in regulating SIRT1 expression in neurons or whether it affects synapses remains largely unknown. Here, we show that insulin promotes neurite outgrowth and increases SIRT1 expression in SH-SY5Y cells. LY294002, a phosphatidylinositol 3-kinase inhibitor, inhibited the expression of insulin-induced increases in SIRT1. Conversely, the downregulation of SIRT1 using a SIRT1 inhibitor and SIRT1-siRNA resulted in a significant reduction in the length of neurite outgrowth. Taken together, these results suggest that the regulation of SIRT1 by insulin is important for the neurite outgrowth of neuroblastoma cells.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Liu Y,Yao Z,Zhang L,Zhu H,Deng W,Qin Cdoi
10.1016/j.neuroscience.2013.01.034subject
Has Abstractpub_date
2013-05-15 00:00:00pages
371-80eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00071-7journal_volume
238pub_type
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