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The SNP in the promoter region of the bovine ELOVL5 gene influences economic traits including subcutaneous fat thickness.

Abstract：

:Genetic analyses have contributed to improvements of economically important traits derived from adipose tissue such as fatty acid composition in beef. Elongation of very long chain fatty acids (ELOVL) genes encode for the enzymes that play an important role in elongation of long-chain fatty acids. In this study, we aimed to discover genetic polymorphisms of ELOVL gene family in cattle populations to develop genetic markers. As a result, five synonymous mutations were detected in the coding regions of the ELOVL1, ELOVL2, ELOVL3 and ELOVL5 genes. In addition, six mutations were identified in promoter region of the ELOVL5. Two of five mutations in the promoter region of ELOVL5 were expected to alter the ELOVL5 expression and influence the economic traits, because of the high synteny of the region which was essential for activation of Elovl5 in mouse. Therefore, we performed association analysis between the genotypes and traits and our result revealed that T allele of g.-110T>C in ELOVL5 gene promoter indicated significantly thinner subcutaneous fat thickness (TT, 2.39 cm; CT, 2.35 cm) than that of C allele (CC, 2.68 cm) in a Japanese Black population. Our results suggest that the g.-110T>C is a useful genetic marker for the breeding in beef cattle.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Matsumoto H,Shimizu Y,Tanaka A,Nogi T,Tabuchi I,Oyama K,Taniguchi M,Mannen H,Sasazaki S

doi

10.1007/s11033-012-2398-x

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

3231-7

issue

4

eissn

0301-4851

issn

1573-4978

journal_volume

40

pub_type

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